1,720,979 research outputs found
The physiologic and pharmacologic factors protecting the lens transparency and the update approach to the prevention of experimental cataracts: A review
No full textIn this review some of the so far identified mechanisms implicated in experimental and human cataractogenesis are reviewed. The oxidative insult, the osmotic insult (sugar cataracts and ionic imbalance cataracts), the role of tryptophan, of lysophosphatidylcholine and docohexanoic acid in primary and secondary cataracts are summarized. It is not always possible to identify the primary effect of cataractogenic mechanisms: the human 'idiopathic' cataract is probably a multifactorial disease. In the aging lens and under stress conditions (osmotic and oxidative) the physiologic defense systems of the lens appear to be inadequate. Even if conditions of avitaminosis aren't the cause of deterioration of the adult human lens, it has been demonstrated that the supplementation or the deficiency of some nutritional factors may influence the course of cataract
Vitamin E and red blood cell glutathione
No full textHigh doses of orally administered vitamin E (1000 IU/day) have been given to ten normal volunteers. Ten control subjects received placebo. Red blood cell glutathione was significantly higher in treated subjects than in the controls (controls: 267.5 ± 15.7 μg/mL; treated: 374.8 ± 17.3 μg/mL). These findings could be explained by an increase of glutathione synthesis brought about by the stimulation of glutathione synthetase activity. An alternative possibility is a reduced utilization of glutathione for the detoxification of free radicals. These two mechanisms could be effective in counteracting the glutathione content feedback of the synthetizing enzymes. © 1985
Enzymatic methyl esterification of the protein in bovine crystalline lens in culture
No full textIn the present paper a study on the enzymatic methyl esterification of proteins in the bovine lens has been presented. The data obtained show that the synthesis of the methyl donor (AdoMet) as well as the methyl esterification of proteins are operative in the lens incubated in the presence of L-(methyl-14C) methionine and the amount of labelled methyl esters decreases during cell ageing. Furthermore, the Authors suggest the usefulness of this model system in the evaluation of the overall AdoMet metabolism in aging
Visual acuity change after intravitreal bevacizumab for exudative age-related macular degeneration in relation to subfoveal membrane type
No full textPurpose: To examine an association between the subfoveal neovascular membrane type and visual acuity change after intravitreal bevacizumab injection for exudative age-related macular degeneration (AMD). Methods: We carried out a clinical, retrospective, interventional case-series study including 66 consecutive patients (67 eyes) with exudative AMD who received an intravitreal injection of 1.5 mg bevacizumab. Study subgroups included the occult type without or with minimally classic subfoveal neovascularization (n = 28 eyes, 42%), predominantly or purely classic subfoveal neovascularization (n = 22 eyes, 33%), and eyes with retinal pigment epithelium detachment (n = 17 eyes, 25%). Follow-up was ≥ 2 months. Results: The maximal visual acuity (VA) gain (mean ± standard deviation - 0.07 ± 0.30 logMAR, 0.5 ± 2.9 Snellen lines; p = 0.87), and VA gain at 1 month (p = 0.10), 2 months (p = 0.77) and 3 months (p = 0.35) after the injection did not vary significantly between the three study subgroups. Correspondingly, a multivariate analysis did not reveal a statistically significant (p = 0.57) influence of subfoveal lesion type on gain in VA. Conclusions: Visual improvement after intravitreal bevacizumab does not differ markedly between various types of subfoveal neovascularization in AMD. © 2007 The Authors Journal compilation 2007 Acta Ophthalmol Scand
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