1,721,100 research outputs found
Pollution Abatement and Lobbying in a Cournot Game:An Agent-Based Modelling Approach
No full textThe application of Agent-Based Modelling to Game Theory allows us to benefit from the strengths of both approaches, and to enrich the study of games when solutions are difficult to elicit analytically. Using an agent-based approach to sequential games, however, poses some issues that result in a few applications of this type. We contribute to this aspect by applying the agent-based approach to a lobbying game involving environmental regulation and firms' choice of abatement. We simulate this game and test the robustness of its game-theoretical prediction against the results obtained. We find that while theoretical predictions are generally consistent with the simulated results, this novel approach highlights a few differences. First, the market converges to a green state for a larger number of cases with respect to theoretical predictions. Second, simulations show that it is possible for this market to converge to a polluting state in the very long run. This result is not envisaged by theoretical predictions. Sensitivity experiments on the main model parameters confirm the robustness of our findings
L'evento del sesso e i segni dell'amore
No full textUn contributo sui temi dell'amore e della sessualità in Lacan e Badiou
Aging and IoT: developing innovative solutions in a Quadruple Helix approach
Full text linkThe paper investigates, through the use of a case study, how local firms can promote technological advancements in a very specific field, such as the one of ICT and IoT applied to the care of elderly people, benefiting from relationships with institutions, enterprises, universities and users in a Quadruple Helix Model. The firm selected, which is launching innovative solutions and systems of connected care and wellness, provides evidence on how technological improvement can flourish if a collaborative approach is followed
Treatment with EGF increases the lenght of S-phase after partial hepatectomy in rat changing the activities of CDKs.
No full textLiver proliferation occurs in the presence of mitogenic stimuli such as partial hepatectomy or growth factors. In this work we investigate how partial hepatectomy and Epidermal Growth Factor (EGF) affect hepatocyte proliferation by modulating cell cycle regulators. EGF administered to non-operated rats increased PCNA (proliferating cell nuclear antigen) expression, whereas when EGF was administered to partially hepatectomized rats it was able to anticipate the increase in PCNA expression to 18h after PH and to prolong it to 34h. Cell cycle progression was examined by monitoring specific markers of late G1- and S-phases. Western blot analysis showed that both treatment with EGF alone and treatment with EGF after PH induce the expression of cyclins D1 and A and of p21(cip1), but inhibites the expression of cyclin E and p27(kip1). EGF administration after PH also significantly affected the activity of the cyclin D1-cdk4 and cyclin E-cdk2 complexes, mainly by changing their time progression: it accelerated the increase in activity to 18h and caused a subsequent drop in activity after 34h; it delayed the activity of the cyclin A-cdk2 complex to 34h. In conclusion we observed that EGF modulates the activity of cdk complexes and induces a different linkage with inhibitory proteins that demonstrates their dual role, depending on their association with different cyclin-cdk complexes
Oleic acid but not fructose induces steatosis and insulin resistance in primary adult and fetal hepatocytes. 3,5-T2 prevents and reverts these effects differently in adult and fetal cells.
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The lobular expression of the rat asialoglycoprotein receptor is regulated at post-transcriptional level
No full textThe purpose of this study was to define the distribution of the
asialoglycoprotein receptor (ASGP-R) main peptide, rat hepatic lectin
(RHL)-1, within the rat liver lobule and to investigate its possible modulation
in physiological states characterised by marked changes of receptorial
expression. In particular, we chose livers from rats partially hepatectomised
or at the end of pregnancy, as models, respectively, of decreased or increased
expression of the ASGP-R, and used the in situ hybridisation and
immunocytochemistry techniques to analyse in parallel the lobular
distributions of RHL-1 mRNA and protein. In normal rat liver, although the
RHL-1 mRNA was homogeneously distributed, the RHL-1 peptide was
predominantly localised on the surface of pericentral hepatocytes with a
gradient of expression towards the periportal zone. This gradient of
expression of RHL-1 peptide was reduced in regenerating livers, in which the
positive stain was restricted to a few layers of cells around the central vein. In
contrast, livers at the end of pregnancy showed an overall increase of the
peptide with a concomitant flattening of the gradient across the liver plate. In
all the conditions, we never observed important changes in the pattern of
expression of the specific mRNA. These findings indicate that the distribution
of ASGP-R is heterogeneous across the liver lobule, with a pattern of
expression prevalently modulated at the posttranscriptional level
Inclusive universities: evidence from the Erasmus program
Full text linkAbstract The Erasmus Program is the main international mobility program in Europe and worldwide. Since its launch in 1987, it has been growing both in terms of participants and budget devoted to its activities. However, despite the possibility to obtain additional funding, the participation of students with special needs in the program remains extremely low. This work quantifies the participation of these students to Erasmus and explores the network of universities involved in their mobility, along the period 2008–2013. In addition, it proposes a novel index to measure the level of inclusiveness of universities welcoming international students with disabilities. Quantifying and analyzing this aspect could be the basis for better designing targeted policies and for widening the participation of students with impairments to international mobility
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