8 research outputs found
Determination of Glibenclamide By Analytical Spectrophotometry
No full textSimple and rapid spectrophotometric method was developed and applied to determine Glibenclamide (GB) by zero spectrophotometric method and first derivative spectrophotometric method for determining of (GB) in the presence of Metformin hydrochloride (MET). Zero spectrophotometric (ZS) method was applied for the determination of (GB) at λmax = 300 nm. Linearity range was (4 – 360) μg/mL. Regression analysis showed a good correlation coefficients R2 = 0.99993. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.65 μg/mL and 2.31 μg/mL, respectively. First derivative spectrophotometric (1DS) method was applied for the determination of (GB) in the presence (MET). (GB) was determined at 317 nm (1D317). Linearity ranges were (4 – 240) μg/mL for (GB). Regression analysis showed a good correlation coefficients R2 = 0.999914. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.60 μg/mL and 1.83 μg/mL for (GB).
The proposed zero spectrophotometry method was applied to analysis individual (GB), and the derivative (1D317) method was applied to analysis (GB) individually or combined with (MET) in Syrian trademark drugs.
The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis
Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry
No full textThe derivative spectrophotometric method was developed and applied for the simultaneous determination of Atenolol (ATE) and Hydrochlorothiazide (HCT) in Tablets formulations. The first derivative spectrophotometric (1DS) method was applied for the determination of (ATE) and (HCT), respectively. (ATE) was determined at 271.9 nm (1D 271.9) and (HCT) was determined at 279.3 nm (1D 279.3). Linearity showed a good correlation coefficients R2 = 0.9994 and R2 = 0.9989 for (ATE) and (HCT), respectively. Linearity ranges were (10 – 280
SIMULTANEOUS DETERMINATION OF TARTRAZINE AND BRILLIANT BLUE IN FOODSTUFFS BY SPECTROPHOTOMETRIC METHOD
No full textObjective: Objective of the study was to develop a simple spectrophotometric method for simultaneous determination of two colorants, Tartrazine (T) and Brilliant Blue (BB), in foodstuffs without any prior treatment.Methods: Derivative spectrophotometric (DS) and spectrophotometric methods were applied for the determination of (T) and (BB), respectively.Results: Tartrazine was determined by first derivative spectrophotometry at 454 nm (1D454); where Brilliant blue was determined by zero-order spectrum at 630 nm. Linearity ranges were 2-24 ðœ‡g/ml for (T) and 2-14 ðœ‡g/ml for (BB), regression analysis showed a good correlation co-efficient R2=0.9999 and R2=0.9998 for (T) and (BB), respectively. The limit of detection (LOD) and limit of quantification (LOQ) was to be 0.12 and 0.35 ðœ‡g/ml for (T), 0.17 and 0.52 ðœ‡g/ml for (BB), respectively.Conclusion: The proposed methods were successfully applied to analysis individual or mixture of Tartrazine and Brilliant Blue in foodstuffs. All studied samples showed dye levels conformity with Syrian legislation. Â
Determination of Pitavastatin Calcium by Analytical Spectrophotometry
No full textSimple and rapid spectrophotometric method for the quantitative analysis of Pitavastatin calcium (PTV) in raw material and tablets pharmaceutical formulation has been described. The method is based on the formation of yellow ion-pair complex between Pitavastatin calcium and Bromocresol purple (BCP) in chloroform medium.
Different parameters affecting the reaction such as: effect of solvents, stability, reagent concentration, correlation ratio, etc. were optimized. The formed complex was quantified spectrophotometrically at absorption maximum 405 nm. Linearity range was 2.20 - 35.23 µg/mL, regression analysis showed a good correlation coefficient R2 = 0.9991. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.367 µg/mL and 1.112 µg/mL respectively. The average percent recovery was found to be (100.62 – 101.14) % for Pitavastatin Calcium. This study was applied on Syrian pharmaceutical trademark: (PAVACRIUM 4 & Londalop). The method was successfully applied for the determination of Pitavastatin calcium in tablets pharmaceutical formulation.
The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis
Analytical Spectrophotometric Study of Enalapril Maleate in Raw Material and Tablets Formulations
No full textSupplementary information files for "Lines in the landscape"
No full textSupplementary files for article "Lines in the Landscape"Ditches (linear constructions which store and/or move water where humans prefer it to go), via irrigation, drainage, and power, have helped drive the development of human societies. Now, ditches and other linear channels, typically carrying water, are numerous and found on every continent. Their form varies widely with use, which includes land drainage, irrigation, transportation, and boundary marking. Ditches support and shape biogeochemical cycles, biotic communities, and human societies, at multiple spatiotemporal scales. However, ditches are frequently overlooked by researchers in many disciplines. Here, we review the largely unrecognized role that ditches play in environmental processes and human societies. The effects of ditches can be both positive (e.g., biodiversity refuges, water for food production, nutrient retention) and negative (e.g., greenhouse gas emissions, dispersal of pollutants). We call for future management to consider and enhance the multifunctional role that ditches can deliver at the landscape-scale.©The Author(s), CC BY 4.0</p
