1,721,348 research outputs found
Nitric oxide mechanisms of nebivolol
No full textβ-blockers are among the most widely used drugs in the prevention and treatment of cardiovascular disease, although they are associated with increased peripheral resistance. Third-generation β-blockers avoid this adverse effect by inducing vasodilation through different mechanisms. In particular, nebivolol, a highly selective blocker of β1-adrenergic receptors, is the only β-blocker known to induce vascular production of nitric oxide, the main endothelial vasodilator. The specific mechanism of nebivolol is particularly relevant in hypertension, where nitric oxide dysfunction occurs. Indeed, nebivolol is able to reverse endothelial dysfunction. Nebivolol induces nitric oxide production via activation of β3-adrenergic receptors, which can explain the good metabolic profile observed after treatment with this drug. Moreover, nebivolol can also stimulate the β3-adrenergic receptor-mediated production of nitric oxide in the heart, and this stimulation can result in a greater protection against heart failure. In conclusion, nebivolol has a unique profile among antihypertensive drugs, adding to a very high selectivity against β1 adrenergic receptors, and an agonist action on β3 receptors and nitric oxide (NO), which has led to clinically significant improvements in hypertensive patients. © The Author(s), 2009
PI3Kγ in hypertension: A novel therapeutic target controlling vascular myogenic tone and target organ damage
No full textIn the past decade, several studies have characterized a number of cellular and molecular mechanisms that contribute to the regulation of the vascular myogenic response, thus affecting blood pressure regulation. Recently, phosphoinositide 3-kinase γ (PI3Kγ) has been identified as a main regulator of vascular myogenic tone and blood pressure, a result further strengthened by a highly significant genome-wide association of a single nucleotide polymorphism flanking this gene with blood pressure regulation, in a large human population. The goal of this review is to summarize the available information regarding the mechanism whereby PI3Kγ exerts blood pressure control, regulating myogenic tone at the level of L-type calcium channel in smooth muscle cells. Moreover, an overview of the pharmacological approaches available for targeting this signalling pathway shows that PI3Kγ is a suitable candidate for antihypertensive therapy, capable of lowering blood pressure. Finally, a survey of the studies dissecting the role of PI3Kγ in pathological conditions that are typically induced by hypertension in its target organs provides a more complete picture of the high potential of this novel therapeutic approach for fighting hypertension and, at the same time, its target organ damage, independently of bloodpressure-lowering effects. © 2012 The Author
METODOLOGIE INFORMATICHE APPLICATE AGLI SCAVI ARCHEOLOGICI
No full textInformatic methods applied to archaeological excavations
In the last decades the use of information technology in archaeology has opened the way to new and increasingly useful and sophisticated systems of documentation; however it is necessary the definition of an adequate theoretical basis and the discussion of the documentation methods adopted, which are specific to each archaeological context. The archiving of archaeological data constitutes an essential basis for the formulation of reconstructive hypotheses and interpretative scenarios and, at the same time, it allows the control and the verification by the scientific community, as well as the possibility of review and the formulation of new hypothesis. The aim of this thesis is to present a new methodological model applied to the palaeolithic site of Isernia La Pineta (Isernia, Italy), characterized by an extraordinary concentration of archaeological pieces and a complex depositional and post-depositional phenomena. This new model, based on the registration of archaeological data for the formalization and processing information and digital contents, has allowed the revision and the rielaboration of the traditional technical documentation. The application of this new methodological model, created ad hoc, has allowed us to fully achieve the preset objectives: the speed of data acquisition has increased along with the degree of precision and accuracy of the same and, simultaneously, it was recorded a reduction of errors in the process of documentation. Beyond the application to the specific context of Isernia La Pineta, the most interesting element of this new methodological model is the possibility of replication in other archaeological contexts. Effectively, it is a model which combines simplicity and versatility of use and it does not require large investments and even special computer knowledge and skills for its use. It also allows the visualization and updating in real time of excavation data and, guaranteeing a link between excavation area and laboratory, a control of the data, resulting in a reduction of the errors
From clinical observations to molecular mechanisms and back to patients: The successful circuit of the CANTOS study
No full textRicerche preistoriche in Indonesia: il sito di Batu Hapu nel Borneo
No full textIl progetto, forte di una buona conoscenza delle problematiche inerenti le metodologie di studio applicate alla ricerca preistorica, intende apportare un contributo innovativo per la ricostruzione del
primo popolamento dell’Indonesia grazie all’applicazione delle più recenti acquisizioni metodologiche, concettuali e tecnologiche della comunità scientifica, in stretta collaborazione con le professionalità locali, esperte nello studio, tutela e valorizzazione del patrimonio archeologico
Applicazioni GIS per l'interpretazione della paleosuperficie di Isernia La Pineta
No full textRaramente, la distribuzione spaziale dei reperti archeologici in siti del Paleolitico è il risultato di un indisturbato e non selettivo abbandono antropico. Spesso, questa distribuzione è in gran parte determinata da fenomeni post-deposizionali, antropici e non, la cui composizione e sequenza sono difficilmente differenziabili. Tutto ciò soprattutto nel caso di unità archeostratigrafiche molto ricche, derivanti da una prolungata occupazione umana e corrispondenti a veri e propri palinsesti, e di numerose attività umane che limitano la possibilità di riconoscere chiare tendenze di distribuzione e di interpretare il loro significato. In considerazione dei numerosi fattori di disturbo, le analisi spaziali intra-site, integrate in un approccio multidisciplinare, sembrano essere attualmente le più avanzate tecniche di indagine spaziale. Queste hanno maggiori possibilità di risolvere tali problemi complessi, la cui ricostruzione gioca, senza dubbio, un ruolo decisivo nella convalida delle successive analisi deduttive
PlGF, immune system and hypertension
Full text linkThe huge diffusion of hypertension and its
associated complications has a significant impact on
public health [1]. However, despite the high prevalence
of essential hypertension and many efforts of research,
the basic pathophysiological causes remain puzzling
Informatizzazione dei dati
No full textRiassunti del Workshop “Incontri nella Preistoria” (Progetto LO.RE.DE.MO - FESR
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