1,721,664 research outputs found
2001-2011: a decade of the LADIS (leukoaraiosis and DISability) study : What have We learned about white matter changes and small-vessel disease?
No full textOver the last 20 years, evidence about the clinical correlates of cerebral white matter changes (WMC; also called leukoaraiosis) has been accumulating. WMC are now listed among the neuroimaging expressions of cerebral small-vessel disease and are no longer considered an innocuous finding because they are associated, in cross-sectional surveys, with various disturbances and, in follow-up studies, with poor prognosis. The Leukoaraiosis And DISability (LADIS) study has contributed substantially to this body of knowledge. LADIS is a European multicenter collaboration that was started in 2001 with the aim of assessing the independent role of WMC in predicting disability in subjects aged 65-84. The main results of the LADIS study have been released in 2009 with the demonstration that severe WMC more than double the risk of transition from an autonomous to a dependent status after 3 years of follow-up. The LADIS study has also contributed more focused substudies assessing the possible role of WMC in the decline of cognitive and motor performances, depressive symptoms associated with aging and cerebrovascular diseases, urinary disturbances, and also the role of other brain lesions (lacunar infarcts, cerebral atrophy, and corpus callosum morphology). The LADIS study provides a good example of harmonization of instruments (MRI protocol, clinical, neuropsychological, and functional scales) within an international collaboration. Currently, the LADIS study is providing data about the natural history of WMC. In this paper, we review the background and the main results of the LADIS study. This review puts forward some considerations for future studies in the field
Impact of cerebral white matter changes on functionality in older adults : an overview of the LADIS Study results and future directions
No full textThe evidence on the clinical significance of cerebral white matter changes (WMC) has mounted over the past few decades. WMC are recognized as one of the neuroimaging features of cerebral small vessel disease, and are associated with various disturbances and a poor prognosis. The Leukoaraiosis and Disability (LADIS) Study has contributed substantially to this body of knowledge. LADIS is a European multicenter collaboration aimed at assessing the role of WMC as an independent predictor of the transition to disability in initially non-disabled patients aged 65-84 years. Besides the demonstration that severe WMC cause a more than double risk of transition from an autonomous to a dependent status after 3 years of follow-up, the LADIS Study has also provided evidence on the role of WMC in relation to the decline of cognitive and motor performances, depressive symptoms associated with aging and cerebrovascular diseases, the presence of urinary disturbances, and various neurological abnormalities. The possible role of other lesions (lacunar infarcts, cerebral atrophy, corpus callosum morphology) and microstructural abnormalities (diffusion-weighted imaging changes in normal appearing brain tissue and in WMC) has also been investigated. In the present article, we review the main results of the LADIS Study and offer some considerations for future developments in the field, paying attention to the potential use of WMC progression as a surrogate marker in intervention trials in cerebral small vessel diseases. We also discuss some therapeutic perspectives regarding the beneficial impact of physical activity on the risk of vascular cognitive impairment in patients with WMC
Works by Ladis Sabo Exhibition Brochure
No full textThis digital image was scanned by Grayson Burke and uploaded to DLynx by the Visual Resources Center in Spring 2020.This is an image of the brochure for Ladis Sabo's exhibition in the Clough-Hanson Gallery. The exhibition ran from February 28, 2003 to April 2
"Works by Ladis Sabo" Exhibition Postcard
No full textThis poster was scanned in the VRC during summer 2014. The original may be viewed in the College Archives.This is a digital copy of the exhibition postcard for Works by Ladis Sabo. This exhibition showed at the Rhodes College Clough-Hanson Gallery February 28 - April 2, 2003. The image on the front of the postcard is Billiard Par/or, Oil on canvas, 20" x 26" 1945. Courtesy of the John & Susan Jerit Collection
Assessing Greek grand strategic thought and practice : insights from the strategic culture approach
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Appel à contribution : Andrew Ladis Memorial Trecento Conference, Frist Art Museum and Vanderbilt University, Nashville, 7 au 9 janvier 2021, date limite 6 avril 2020
No full textAndrew Ladis Memorial Trecento Conference Frist Art Museum and Vanderbilt University, Nashville, January 7–9, 2021 The Andrew Ladis Memorial Trecento Conference is held biennially in honor of the art historian Andrew Ladis (1949–2007), an authority on Taddeo Gaddi and Giotto and an inspiring teacher. The conference—the only gathering of its kind—emphasizes trecento Italian art as a fruitful area of research and offers participants the opportunity to exchange ideas formally and informally in a..
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study.
Full text linkWOS:000280103900012 (Nº de Acesso Web of Science)“Prémio Científico ISCTE-IUL 2012”Memory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes (WMC) on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 +/- 5 years old, 55% women, 9.6 +/- 3.8 years of schooling). At end of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during the follow-up (beta = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study, self perceived memory complaints predicted AD but not vascular dementia in elderly subjects with WMC living independently
Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study
No full textObjective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Base
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