1,720,975 research outputs found
Livelli ematici di b-endorfina ed acido lattico in cavalli adibiti al lavoro di maneggio
No full text). Analysis of subchondral cortical plate and trabecular bone in osteoarthritis experimentally induced in goat tibia. Preliminary results.
No full textGiardia and Cryptosporidium in water: evaluation of two concentration methods and occurrence in wastewater
No full textBody mass index and adipokines/cytokines dysregulation in systemic sclerosis
Full text linkBody fat has regulatory functions through producing cytokines and adipokines whose role in the pathogenesis of systemic sclerosis (SSc) is currently emerging. Changes in body mass, either over- or underweight, entail a dysregulation of the cytokine/adipokine network that may impact upon SSc disease activity. We evaluated serum levels of adipokines and cytokines in SSc patients and correlated them to clinical features and body mass index (BMI) categories. The study included 89 SSc patients and 26 healthy donors (HD). Serum levels of adiponectin, leptin, resistin, visfatin, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-2, IL-10 and IL-17A were measured by multiplex immunoassay and correlated to BMI and disease-specific features. Student’s t-test or analysis of variance (ANOVA) were used for comparisons between groups. Spearman’s or Pearson’s tests were used for correlation analysis. Serum levels of TNF-α, IL-2, leptin and resistin were significantly higher in SSc than in HD. Leptin levels were significantly higher in interstitial lung disease (ILD)- and pulmonary arterial hypertension (PAH)-SSc subgroups. The highest levels of IL-17A, IL-2, IL-10, leptin and visfatin were detected in SSc patients with obesity (p < 0.01). Conversely, underweight SSc patients showed the highest TNF-α levels (p < 0.05). Adipokines, IL-2, IL-10 and IL-17A were found to be increased in SSc patients with obesity, but whether or not they play a role in the pathogenesis of the disease remains to be investigated. Intriguingly, underweight patients had the highest TNF-α levels, suggesting a potential role of TNF-α in inducing the cachexia observed in long-lasting disease
AB0134 Phosphorelated stat3 expression in peripheral blood mononuclear cells in rheumatoid arthritis
No full textConference: Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 201
Serum sCD40L levels are increased in patients with psoriatic arthritis and are associated with clinical response to apremilast
Full text linkThe pathogenesis of psoriatic arthritis (PsA) involves several pathways, including the CD40/CD40L signaling which promotes the release of multiple cytokines. Transmembrane CD40L is also released in soluble form (sCD40L) and phosphodiesterase 4 (PDE4) seems to be involved in its cleavage. We aimed to investigate whether apremilast, a PDE4 inhibitor, could modify circulating levels of sCD40L in PsA patients, and the possible associations of these changes with clinical response. Consecutive PsA patients starting apremilast in routine clinical practice were prospectively observed. Disease Activity of Psoriatic Arthritis (DAPSA), Psoriasis Area Severity Index (PASI), Leeds Enthesitis Score (LEI) and serum samples were collected at baseline and at 6 months. Samples were run in a Bio-Plex ProTM plate for sCD40L. To investigate the association of sCD40L level with DAPSA based minor response, low disease activity (LDA) and/or remission at 6 months of treatment, multivariate logistic regression models with backward selection (P < 0 center dot 05) were built. We studied 27 patients (16 of 27 women, 59 center dot 6%) with PsA and mean age [+/- standard deviation (s.d.)] of 58 center dot 4 +/- 10 years. A significant reduction of the mean values of DAPSA, LEI and PASI was detected at 6 months. Mean serum levels of sCD40L decreased from baseline 5364 +/- 2025 pg/ml to 4412 +/- 2629 at 6 months (P = 0 center dot 01). Baseline DAPSA [odds ratio (OR) = 0 center dot 80, 95% confidence interval (CI) = 0 center dot 65-0 center dot 98] and sCD40L (OR = 1 center dot 001, 95% CI = 1 center dot 0001-1 center dot 0027) were independently associated with DAPSA LDA/remission at 6 months. In PsA patients, sCD40L levels decrease upon apremilast treatment and might predict short-term clinical response to apremilast
Analysis of subchondral cortical plate and trabecular bone in osteoarthritis experimentally induced in goat tibia. Preliminary results
No full textSAT0571 Role of Obesity in the Expression of Cytokines and Metalloproteinases in Human Osteoarthritis Chondrocytes
No full textEULAR congress Paris 201
Chondrocytes treated with different shock wave devices
Full text linkBackground: Shock wave treatment is used for several orthopedic diseases and there are different devices available. Until now, there have been no experimental studies on the effects of these different generators. Methods: We carried out an experimental study to compare the effects of three focused generators (electro-magnetic, piezoelectric and electro-hydraulic) as well as a radial generator on healthy and osteoarthritis chondrocytes. Results: By the analysis of our results, we may exclude significant differences between the different generators, even though there is a greater action specificity for electro-magnetic and piezoelectric generators. Conclusions: The smaller size of the focus of the latter two generators guarantees a greater concentration of energy in the target. The biological effect of the increase of IL-10 and reduction of both N-Cadherin and B-Catenin in chondrocytes in healthy subjects and those affected by osteoarthritis confirms the therapeutic potential of ESWT in cartilage diseases, such as osteoarthritis. In clinical practice it is important to introduce the parameter of total energy. This allows us to standardize the treatment and to manage the variability related to the different types of device and size of the focus. Level of evidence: IIb. © 2017, CIC Edizioni Internazionali s.r.l. All rights reserved
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