1,721,335 research outputs found
Could ruxolitinib be effective in patients with COVID-19 infection at risk of acute respiratory distress syndrome (ARDS)?
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Immunogenetica: aspetti clinici e popolazionistici. Genetica formale e popolazionistica (5° di cinque parti)
No full textHumanizing medical structures: the issue of a low-bacterial environment in the Bone Marrow Transplant Unit
No full textA low-bacterial single room is an isolated space-time environment. In this special unit, allogenic bone marrow transplantation treated patients receive intensive care. Environmental stressors can influence emotional stability and perceived autonomy. This study analysed the effect of isolation on the distress and psychophysical perception. The Experiential World Inventory (EWI) of Bonneau and El Meligi was distributed to 18 patients (10 M, 8 F, mean age 39 years) at the beginning and the end of isolation (from 32 to 63 days, mean 45). Patients received bone marrow transplant from related or unrelated donors, after reduced or standard conditioning regimens. The questionnaire investigates 12 distinct scales: sensorial perception, time perception, body image, self image, social behaviour, thought, dysphoria, impulsiveness, hyper and hypoesthesia, euphoria, anxiety. The Italian edition of the EWI reports the reference values of a control group of 100 normal subjects. At the beginning of isolation, significant differences were seen between patients and control group for the impulsiveness and euphoria scales; after isolation, significant variations of scores were obtained on perception of time, body image, social behaviour, euphoria and impulsiveness. Prolonged isolation in a germ-free single room may induce progressive impairment of sensorial perception and body image, acceleration of time perception with reduced coping abilities, negative evaluation of self and a tendency to decrease communication with others. A better understanding of the relationship between the person and clinical environment, careful monitoring of psychological stability and reduction of environmental stressors, may improve coping in these patients
Contu L., La Nasa G., Carcassi C.: Immunogenetica: aspetti clinici e popolazionistici. Il sistema HLA: concetti generali (1° di cinque parti)
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Efficacia e tollerabilità di nilotinib in terza linea in un paziente anziano con LMC = Efficacy and safety of nilotinib as third-line therapy in an elderly patient with CML
No full textThe usefulness of artificial neural networks in predicting the outcome of hematopoietic stem cell transplantation: a crystal ball to foresee the future?
No full textA simulated case of chronic myeloid leukemia: the growing risk of Munchausen’s Syndrome by internet
No full textBone marrow homing and engraftment defects of human hematopoietic stem and progenitor cells
No full textHoming of hematopoietic stem cells (HSC) to their microenvironment niches in the bone marrow is a complex process with a critical role in repopulation of the bone marrow after transplantation. This active process allows for migration of HSC from peripheral blood and their successful anchoring in bone marrow before proliferation. The process of engraftment starts with the onset of proliferation and must, therefore, be functionally dissociated from the former process. In this overview, we analyze the characteristics of stem cells (SCs) with particular emphasis on their plasticity and ability to find their way home to the bone marrow. We also address the problem of graft failure which remains a significant contributor to morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Within this context, we discuss non-malignant and malignant hematological disorders treated with reduced-intensity conditioning regimens or grafts from human leukocyte antigen (HLA)-mismatched donor
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