933 research outputs found
Relatório de revisão por pares para: Diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras
No full textRevisão por pares do artigo:
SOUZA, R. S. R. e; DINIZ, M. Diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras. Educ. Form., Fortaleza, v. 7, p. e6779, 2022. DOI: 10.25053/redufor.v7i1.6779. Disponível em: https://revistas.uece.br/index.php/redufor/article/view/6779.
Como citar este relatório:
ZUIN, A. L. A.; GRACIOLI, F. R. Relatório de revisão por pares para: diálogos entre educação, cidade e patrimônio: investigando produções científicas brasileiras. Educ. Form., 2022, Zenodo. Disponível em: https://doi.org/10.5281/zenodo.6817649.
Revisado por:
Aparecida Luzia Alzira Zuin (Universidade Federal de Rondônia, Porto Velho, Rondônia, RR, Brasil)
Filipe Rafael Gracioli (Instituto do Patrimônio Histórico e Artístico Nacional, Rio de Janeiro, Rio de Janeiro, RJ, Brasil
The Role of Surgery in Pleural Mesothelioma: A Journey through the Evidence, MARS 2 and Beyond
Get PDFPleural mesothelioma (PM) is a rare incurable disease, predominantly linked to asbestos exposure. Not only is diagnosis difficult, but treatment choices are often limited to systemic anti-cancer treatment with chemotherapy or immunotherapy. Surgery has been employed for decades, but its application has been fiercely debated despite some randomized controlled trials such as the recent Mesothelioma and Radical Surgery 2 (MARS 2) study. We provide a commentary on this controversial topic. © The Author(s) 2025
Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration
No full textLittle is known about the effects of cholesterol-lowering agents in hypercholesterolemic patients with primary biliary cirrhosis (PBC). The aim of this study was to compare the changes induced by simvastatin and ursodeoxycholic acid (UDCA) on cholesterol metabolism in patients with PBC and preserved liver function. Six patients with PBC were administered simvastatin (40 mg/day) for 30 days and, after a washout period of 30 days, ursodeoxycholic acid (600 mg/day) for 30 days. Serum levels of lathosterol, campesterol, 7 alpha-hydroxycholesterol, and 27-hydroxycholesterol were measured by gas chromatography-mass spectrometry. During simvastatin administration, reduction of cholesterol levels (34% in 30 days) was paralleled by the decrease of lathosterol (55%), whereas concentrations of campesterol and of the two hydroxysterols were not substantially modified. During ursodeoxycholic acid administration, a trend toward a decrease of serum cholesterol concentrations was observed after only one year of treatment, and these changes were paralleled by the decrease of campesterol serum levels. Both simvastatin and UDCA were well tolerated, and a reduction of serum liver enzyme levels occurred with the latter. Simvastatin proved to be safe and effective in reducing serum cholesterol levels in patients with PBC by an inhibitory effect on cholesterol synthesis occurring within 24 h. --Del Puppo, M., M. Galli Kienle, A. Crosignani, M. L. Petroni, B. Amati, M. Zuin, and M. Podda. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. J. Lipid Res. 2001. 42: 437--441
Phenological observations on shrubs to predict weed emergence in turf
No full textPhenology is the study of periodic biological events. If we can find easily recognizable events in common plants that precede or coincide with weed emergences, these plants could be used as indicators.Weed seedlings are usually difficult to detect in turf, so the use of phenological indicators may provide an alternative approach to predict the time when a weed appears and consequently guide management decisions. A study was undertaken to determine whether the phenological phases of some plants could serve as reliable indicators of time of weed emergence in turf. The phenology of six shrubs (Crataegus monogyna Jacq., Forsythia viridissima Lindl., Sambucus nigra L., Syringa vulgaris L., Rosa multiflora Thunb., Ziziphus jujuba
Miller) and a perennial herbaceous plant [Cynodon dactylon
(L.) Pers.]was observed and the emergence dynamics of
four annual weed species [Digitaria sanguinalis (L.) Scop., Eleusine indica (L.) Gaertner, Setaria glauca (L.) Beauv., Setaria viridis (L.) Beauv.] were studied from 1999 to 2004 in northern Italy. A correlation between certain events and weed emergencewas verified. S. vulgaris and F. viridissima appear to be the best indicators: there is a quite close correspondence between the appearance of D. sanguinalis and lilac flowering and between the beginning of emergence of E. indica and the end of lilac flowering; emergences of S. glauca and S. viridis were predicted well in relation to the end of forsythia flowering. Base temperatures and starting dates required to calculate the heat unit sums to reach and complete the flowering phase of the indicators were calculated using two different methods and the resultant cumulative growing degree days were compared
Splenic haemodynamics and portal hypertension in patients with liver cirrhosis and spleen enlargement.
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Renal and intrarenal blood flow in patients with cirrhosis before and after portal-systemic shunt.
No full textBile acid-induced inhibition of the lymphoproliferative response to phytohemagglutinin and pokeweed mitogen: an in vitro study
No full textThe effects of free and conjugated bile acids on the lymphoproliferative response to phytohemagglutinin (PHA) or pokeweed mitogen (PWM) have been investigated in vitro. Significant inhibition of lymphocyte transformation was observed with 250 mumol/liter of either chenodeoxycholic (CDCA) or cholic acid (CA); the former caused more pronounced inhibition at higher concentrations. This was true whichever mitogen was present. Conjugated bile acids caused lesser degrees of inhibition than the respective free bile acids and the glycoconjugates were more inhibitory than the respective tauroconjugates of the same bile acid. At concentrations of free bile acids which completely suppressed lymphocyte transformation, no cytotoxic effects or impairment of cell viability were detected. Since the concentrations that inhibited the lymphoproliferative response were markedly lower than those reported to induce cell membrane damage, the activity observed can be attributed to a metabolic effect within the cell. Inhibition by bile acids of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase activity, resulting in a reduction of the endogenous cholesterol synthesis required for cell growth and proliferation, might account for our observations. Our results contribute to understanding the nature of the serum-dependent inhibition of lymphocyte transformation reported to exist in cholestatic liver disease
Dal Trentino uno sguardo internazionale su fragola e piccoli frutti: analisi e prospettive del mercato fresco
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