1,721,174 research outputs found
Virtual Activity, Real Pharmacology. Different Approaches to the Search for Bioactive Compounds from Natural Sources
No full textGli Antitumorali Inibitori della Topoisomerasi I: dalla Camptotecina (Camptotheca acuminata Decaisne) all’Irinotecan e al Topotecan
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Hypericum perforatum, a source of neuroactive lead structures
No full textAlthough St. John's wort has been known for thousands of years and has been used for a variety of medicinal purposes, understanding of its activity and mechanisms of action is relatively new and not well understood. While researchers originally thought the naphthodianthrone hypericin was responsible for Hypericum's antidepressant activity, it is now believed some other compound or a combination of constituents exerts their antidepressant activity on the body. Hypericum is unique in that it seems to impact all known neurotransmitters at some level, directly, or indirectly through receptor sensitivity and regulation.
There has been a proliferation of clinical studies on Hypericum in the last ten years, and even though some of these studies might be methodologically flawed, the preponderance of the evidence proves Hypericum to be beneficial for the treatment of mild-to-moderate depression, with a very favorable side effect profile.
One clinical trial carried out using two extracts with different hyperforin content indicate this constituent as (one of) the main active principle responsible for the antidepressant activity
Are acylphloroglucinols lead structures for the treatment of degenerative diseases?
No full textIn recent years a widespread interest in the antidepressant activity of Hypericum perforatum L. has attracted much activity in investigating metabolites from the Guttiferae, many of which are biologically active compounds with an acylphloroglucinol moiety. A common background in the traditional uses of plants belonging to Guttiferae family is their wound healing properties which has been connected to the established antimicrobial activities of the phloroglucinols present. These metabolites share a common acylated 1,3,5-trihydroxy-benzene core of polyketide origin which undergoes alkylation processes. Polycyclic polyprenylated acylphloroglucinols feature a highly oxygenated and densely substituted bicyclo[3.3.1]nonane-1,3,5-trione core appended with prenyl or geranyl side chains. Secondary cyclizations involve the β-diketone and pendant olefmic groups affording adamantanes, homoadamantanes, dihydrofurano- or pyrano- fused structures. These products are claimed to possess antioxidative, antiviral and antimitotic properties. Increasing interest is related to their function in the CNS as modulators of neurotransmitters associated with neuronal damage and depression
Isolation and HPLC determination of the active principles of Rosmarinus officinalis and Gentiana lutea
No full textMedicinal properties of nutritional and healing plants
No full textOver the past 100 years, the development and mass production of chemically synthesized drugs have revolutionized health care in most parts of the word. However, large sections of the population in developing countries still rely on traditional practitioners and herbal medicines for their primary care. It is estimated that about 25% of the drugs prescribed worldwide are derived from plants, and 121 such active compounds are in use. Between 2005 and 2007, 13 drugs derived from natural products were approved in the United States. More than 100 natural product-based drugs are in clinical studies, and of the total 252 drugs in the World Health Organization’s (WHO) essential medicine list, 11% are exclusively of plant origin
Compounds with antimalarial activity
No full textThe present invention relates to antimalarial compounds and pharmaceutical compositions thereof. More precisely, new usnic acid derivatives, conjugation products of usnic acid with biologically active molecules and pharmaceutical compositions thereof are described, which are useful for the prophylaxis and therapy of infections from protozoa of the Plasmodium genus
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