1,721,660 research outputs found
Il vigneto moretto : attualità e storia della viticoltura collinare di San Colombano al Lambo : attività sperimentali dal 1992 al 2002
No full text
Variations induced by innovative planting designes cv. "Sagrantino in Montefalco"-Umbria-Italy. Modifications induites par choix de plantation innovantes sur l production du cultivar "Sagrantino di Montefalco"-Ombrie-Italie
No full textGenetics of nonalcoholic fatty liver disease
No full textEpidemiological, familial, and twin studies indicate that non-alcoholic fatty liver disease, now the leading cause of liver damage in developed countries, has a strong heritability. The common I148M variant of PNPLA3 impairing hepatocellular lipid droplets remodeling is the major genetic determinant of hepatic fat content. The I148M variant has a strong impact on the full spectrum of liver damage related to fatty liver, encompassing non-alcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma, and influences the response to therapeutic approaches. Common variants in GCKR enhance de novo hepatic lipogenesis in response to glucose and liver inflammation. Furthermore, the low-frequency E167K variant of TM6SF2 and rare mutations in APOB, which impair very low-density lipoproteins secretion, predispose to progressive fatty liver. Conclusions These and other recent findings reviewed here indicate that impaired lipid handling by hepatocytes has a major role in the pathogenesis of non-alcoholic fatty liver disease by triggering inflammation, fibrogenesis, and carcinogenesis. These discoveries have provided potential novel biomarkers for clinical use and have revealed intriguing therapeutic targets
Rapporti tra forma di allevamento e cloni nel "Pinot nero" per i diversi indirizzi enologici
No full textAccumulo zuccherino nele uve e maturazione polifenolica
No full textIn un quadro di cambiamento climatico e di mercato è necessario indagare su sistemi di produzione innovativi che permettano di produrre anche i vini > richiesti oggi dal consumatore, compatibilmente con le caratteristiche del vitigno e delle uve e senza snaturarne la tipicita
- …
