656 research outputs found
Trinder, L G, NX73633
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/422161Surname: TRINDER. Given Name(s) or Initials: L G. Military Service Number or Last Known Location: NX73633. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 25954.247483
Item: [2016.0049.54422] "Trinder, L G, NX73633
Drug interference in Trinder reaction
No full textOur recent research of drug interference in Trinder reaction – a widely used chromogenic reaction in the field of clinical biochemistry, was focused on comparison of various drugs and the impact on determination of several biochemical parameters with validated diagnostic kits utilizing Trinder reaction. Our results showed significant alteration of results in therapeutic concentrations of ACC®, Dicynone® and Novalgin® in comparison to the control samples. Dobutamine, Tensamin and ascorbic acid showed significant interference only in samples containing 1 mmol/l of drug.V našem posledním výzkumu lékové interference v Trinderově reakci, široce rozšířené chromogenní reakci v oboru klinické biochemie, jsme se zaměřili na porovnání různých leků a jejich dopad na měření několika biochemických paramerů pomocí validovaných diagnostických souprav využívající Trinderovu reakci. Naše výsledky ukázaly významnou změnu výsledků při terapeutických koncentracích ACC, Dicynonu a Novalginu ve srovnání s kontrolními vzorky. Dobutamin, Tensamin a kyselina askorbová projevovaly významnou interferenci až u vzorků obsahujícíc koncentraci léku 1 mmol/l
A study of zinc transporter 1 and its role in Type 3 Haemochromatosis
No full textHereditary haemochromatosis is an autosomal recessive disorder of iron metabolism, characterised by increased iron absorption and progressive iron accumulation particularly in the liver. It has been shown that hepatocytes can acquire iron in two forms; transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI)1. Known transporters of NTBI into the cell include DMT1 and ZIP14, and FPN is the only transporter known to export iron.
The aims of this study were to characterize the zinc transporter, ZnT-1 and determine whether it is involved in iron transport, specifically as an exporter.
There was a decrease in mRNA expression of the short untranslated isoform of ZnT-1 in double mutant (Hfe -/- and TfR2 Y245X) mouse liver, a trend also seen in TfR1 and Hamp. The long untranslated isoform, however, was significantly higher in the iron-deficient mice as was expression of TfR1 and Ferroportin. Iron and zinc efflux was measured in cells over-expressing ZnT-1 and control cells. There was no difference between over-expressed and control cells in iron efflux. However, at 60 min, over-expressed cells had significantly more zinc efflux than control cells. More zinc than iron was released from the cell.
The results of this study do not support the hypotheses that (i) ZnT-1 reduces intracellular cytoplasmic iron concentration by promoting efflux and 2 ZnT-1 is down-regulated in iron-loaded cells
Emu oil improves clinical indicators of disease in a mouse model of colitis-associated colorectal cancer
No full textLC Chartier, GS Howarth, IC Lawrance, D Trinder, SJ Barker, S Mashtou
Gender differences in airway resistance during sleep
No full text Trinder, John, Amanda Kay, Jan Kleiman, and Judith Dunai.Gender differences in airway resistance during sleep. J. Appl. Physiol. 83(6): 1986–1997, 1997.—At the onset of non-rapid-eye-movement (NREM) sleep there is a fall in ventilation and an increase in upper airway resistance (UAR). In healthy men there is a progressive increase in UAR as NREM sleep deepens. This study compared the pattern of change in UAR and ventilation in 14 men and 14 women (aged 18–25 yr) both during sleep onset and over the NREM phase of a sleep cycle (from wakefulness to slow-wave sleep). During sleep onset, fluctuations between electroencephalographic alpha and theta activity were associated with mean alterations in inspiratory minute ventilation and UAR of between 1 and 4.5 l/min and between 0.70 and 5.0 cmH2O ⋅ l−1 ⋅ s, respectively, with no significant effect of gender on either change ( P > 0.05). During NREM sleep, however, the increment in UAR was larger in men than in women ( P < 0.01), such that the mean levels of UAR at peak flow reached during slow-wave sleep were ∼25 and 10 cmH2O ⋅ l−1 ⋅ s in men and women, respectively. We speculate that the greater increase in UAR in healthy young men may represent a gender-related susceptibility to sleep-disordered breathing that, in conjunction with other predisposing factors, may contribute to the development of obstructive sleep apnea. </jats:p
Improving the network scalability of Erlang
No full textAs the number of cores grows in commodity architectures so does the like- lihood of failures. A distributed actor model potentially facilitates the de- velopment of reliable and scalable software on these architectures. Key com- ponents include lightweight processes which ‘share nothing’ and hence can fail independently. Erlang is not only increasingly widely used, but the un- derlying actor model has been a beacon for programming language design, influencing for example Scala, Clojure and Cloud Haskell.
While the Erlang distributed actor model is inherently scalable, we demon- strate that it is limited by some pragmatic factors. We address two network scalability issues here: globally registered process names must be updated on every node (virtual machine) in the system, and any Erlang nodes that com- municate maintain an active connection. That is, there is a fully connected O(n^2) network of n nodes.
We present the design, implementation, and initial evaluation of a con- servative extension of Erlang – Scalable Distributed (SD) Erlang. SD Erlang partitions the global namespace and connection network using s groups. An s group is a set of nodes with its own process namespace and with a fully connected network within the s group, but only individual connections out- side it. As a node may belong to more than one s group it is possible to construct arbitrary connection topologies like trees or rings
Beyond Conflict: Lessons from the Fields
No full textLabour law is under threat. With crises pervading its normative paradigm, coverage and enforcement, its ability to regulate modern working relationships has recently been questioned. Fundamental to each layer of crisis, whether philosophical, empirical or judicial, is the predominant narrative of conflict as an axiomatic feature of what it means to be employed. This research questions the simplicity of that view and argues that the answer to the discipline’s crisis of identity does not lie in reimagining the crisis but in the reimagination of labour law’s identity. Applying a sociological lens and by focusing on one industry - agriculture - a more contextual picture emerged. Through conducting interviews with 31 farmers and farmworkers in England and Wales regarding their management of the statutory employment rights of status, wages, hours, leave, and health and safety, new insights appeared, to challenge the conflict narrative. In sum, these farmers managed labour rights based on principles of informality, flexibility, professionalisation and “good employership” and not, necessarily, the law. Consequently, legal compliance varied between formal, accidental, presumed and noncompliance, creating a disparity between legal expectation and practice. The reasons for this divergence stemmed from the interplay between agency and structure, and the constraints of the agricultural industry which confined labour decisions. Managing labour rights through these principles, to respond to these constraints, and not via the standard model which law promotes, led to a two-fold impact. First, unintended consequences arose where standardisation failed to reflect the internal realities. Second, workers were not exploited in the absence of law. Instead, relationships were generally reciprocal, mutually contingent and valued. For the law, this queries the authenticity of our paradigm and associated normative models. Instead, a new narrative is needed, built on the preservation of harmonious work relationships, to move labour law out of crisis and beyond conflict
Understanding innovators' experiences of barriers and facilitators in implementation and diffusion of healthcare service innovations: A qualitative study
No full textThis article is made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Barnett et al.Background: Healthcare service innovations are considered to play a pivotal role in improving organisational efficiency and responding effectively to healthcare needs. Nevertheless, healthcare organisations encounter major difficulties in sustaining and diffusing innovations, especially those which concern the organisation and delivery of healthcare services. The purpose of the present study was to explore how healthcare innovators of process-based initiatives perceived and made sense of factors that either facilitated or obstructed the innovation implementation and diffusion. Methods: A qualitative study was designed. Fifteen primary and secondary healthcare organisations in the UK, which had received health service awards for successfully generating and implementing service innovations, were studied. In-depth, semi structured interviews were conducted with the organisational representatives who conceived and led the development process. The data were recorded, transcribed and thematically analysed. Results: Four main themes were identified in the analysis of the data: the role of evidence, the function of inter-organisational partnerships, the influence of human-based resources, and the impact of contextual factors. "Hard" evidence operated as a proof of effectiveness, a means of dissemination and a pre-requisite for the initiation of innovation. Inter-organisational partnerships and people-based resources, such as champions, were considered an integral part of the process of developing, establishing and diffusing the innovations. Finally, contextual influences, both intra-organisational and extra-organisational were seen as critical in either impeding or facilitating innovators' efforts. Conclusions: A range of factors of different combinations and co-occurrence were pointed out by the innovators as they were reflecting on their experiences of implementing, stabilising and diffusing novel service initiatives. Even though the innovations studied were of various contents and originated from diverse organisational contexts, innovators' accounts converged to the significant role of the evidential base of success, the inter-personal and inter-organisational networks, and the inner and outer context. The innovators, operating themselves as important champions and being often willing to lead constructive efforts of implementation to different contexts, can contribute to the promulgation and spread of the novelties significantly.This research was supported financially by the Multidisciplinary Assessment of
Technology Centre for Healthcare (MATCH)
Motor unit activity in upper airway muscles genioglossus and tensor palatini
No full textCommon oscillatory inputs to genioglossus (GG) and tensor palatini (TP) motoneurons were assessed using coherence analysis. Oscillations in the ranges 0-5 Hz (common drive) and 10-30 Hz (short term synchrony) were analyzed. GG and TP electromyograms were recorded via intramuscular fine wire electrodes in 32 subjects during wakefulness. Coherence analysis was conducted on 201 pairs of motor units paired according to their discharge patterns. Results were similar for the two muscles. Common drive was significantly higher for unilateral than bilateral pairs of units (p<.001), and was highest in Inspiratory Tonic pairs and lowest in Tonic pairs (p<.001). Pairs constructed from one muscle had higher common drive than pairs from two muscles (p<.001), the difference being greater for tonic pairs (interaction effect, p=.003). Short term synchrony was weak. The results indicate strong common drive to GG and TP phasic motoneurons, while common drive to Tonic motoneurons was weaker and idiosyncratic to each muscle.John Trinder, Michael Woods, Christian L. Nicholas, Julia K.M. Chan, Amy S. Jordan, John G. Semmle
Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000‐2015: a retrospective multicentre study
No full textBACKGROUND
The diagnostic significance of the atopy patch test for the management of dermatitis possibly triggered by aeroallergens is still controversial. However, sufficiently large studies with routinely tested standardized aeroallergen patch test preparations in dermatitis patients are lacking.
OBJECTIVE
To evaluate the reaction frequency and the reaction profiles of 10 until mid-2015 commercially available, standardized aeroallergen patch test preparations of the 'Stallerpatch' test series (Stallergenes, Antony Cedex, France) in a large multicentre patient cohort.
METHODS
A retrospective data analysis of patients with suspected aeroallergen-dependent eczematous skin lesions was performed, who were patch tested in 15 Information Network of Departments of Dermatology-associated clinics between 2000 and 2015. Patients were stratified according to their atopic dermatitis (AD) status.
RESULTS
The study group included 3676 patients (median age 41 years, 34.8% males, 54.5% AD). The most common aeroallergens causing positive patch test reactions were Dermatophagoides pteronyssinus (19.6%), Dermatophagoides farinae (16.9%), birch (6.2%), timothy grass (6.0%), cat dander (5.4%), mugwort (4.9%) and dog dander (4.6%). Reactions to other pollen allergen preparations, that is 5 grasses (3.2%), cocksfoot (2.1%) and plantain (1.6%), were less common. Positive patch test reactions to aeroallergens were consistently more frequent in patients with AD. These patients showed proportionally less dubious, follicular, irritant and weak positive reactions. Independent of AD status, a patient history of past or present allergic rhinitis was associated with an increased chance of a positive aeroallergen patch test reaction to pollen allergens.
CONCLUSION
The aeroallergen patch test is a useful add-on tool in clinical routine, especially in patients with AD and/or respiratory allergy. A patch test series comprising Dermatophagoides pteronyssinus, Dermatophagoides farinae, birch, timothy grass, cat dander and mugwort seems to be suitable. Controlled studies with specific provocation and elimination procedures are required to further evaluate the diagnostic significance of the proposed screening series
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