763 research outputs found
Reducing vascular complications of large-bore sheaths removal with a novel post-closure technique: Adapt and evolve
No full textTreatment of aortic stenosis in patients with chronic liver disease: Another win for transfemoral TAVR?
No full textChronic liver disease is associated with increased operative risk of open-heart surgery. In this study, transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) carried high periprocedural mortality, but transfemoral TAVR appeared to be superior to SAVR in terms of long-term survival. Better risk stratification tools are needed for patients with liver dysfunction to avoid futile TAVR and SAVR procedures
TAVR versus SAVR in patients with severe aortic stenosis and concomitant end stage liver disease: When less is more
No full text
Negative impact of coronavirus on interventional cardiology fellows' training: Let's limit collateral damage of the pandemic
No full textPreexisting diastolic dysfunction in patients undergoing TAVR matters—But what about diastole the day after TAVR?
No full textL ́UNIONE EUROPEA TRA IL DIRITTO ENERGETICO E IL DIRITTO AMBIENTALE
No full textNelle società attuali il fabbisogno di energia appare in costante crescita e si è legato, ormai da qualche decennio, a emergenze ambientali e climatiche. Le prospettive di crescita della popolazione mondiale, e l’impatto che ciò avrà sul Pianeta anche in termini di fabbisogno energetico, coniugate con l’esaurimento delle fonti di energia tradizionale, i rischi ecologici e l’impatto ambientale derivanti da uno sfruttamento inconsulto delle energie fossili, hanno costretto i legislatori europei, ma non solo, a individuare norme in grado di regolare la produzione di energia a livello nazionale e sovranazionale.In today ́s societies, the need for energy appears to be constantly growing and has been linked, for some decades now, to environmental and climatic emergencies. The growth prospects of the world population, and the impact this will have on the planet also in terms of energy needs, combined with the exhaustion of traditional energy sources, the ecological risks and the environmental impact deriving from the reckless exploitation of energy fossils, have forced the European legislators, but not only, to identify rules capable of regulating the production of energy at national and supranational level
Metabolic treatment with L-carnitine in acute anterior ST segment elevation myocardial infarction - A randomized controlled trial
No full textBACKGROUND:
Administration of L-carnitine in patients with anterior acute myocardial infarction (AMI) prevents left ventricular remodeling. Current study was aimed to assess the effect of L-carnitine administration on mortality and heart failure in patients with anterior AMI.
METHODS:
CEDIM 2 trial was a randomized, double-blind, multicenter, placebo-controlled trial planned to enroll 4,000 patients with acute anterior AMI. The trial was interrupted after the enrolment of 2,330 patients because of the lower than expected enrolment rate. The primary end point was a composite of death and heart failure at 6 months; 5-day mortality was the secondary end point.
RESULTS:
During the 6-month follow-up, the primary end-point was not significantly different between the L-carnitine and placebo group (9.2 vs. 10.5%, p = 0.27). A reduction in mortality was seen in the L-carnitine arm on day 5 (secondary end-point) from randomization (HR = 0.61, 95% CI 0.37-0.98, p = 0.041).
CONCLUSIONS:
In CEDIM 2 trial L-carnitine therapy led to a reduction in early mortality (secondary end-point) without affecting the risk of death and heart failure at 6 months in patients with anterior AMI, leading to a non-significant finding with respect to the primary end-point
Anatomical and pathophysiological considerations on the left main coronary artery
No full textThe left main is the first segment of the left coronary artery and is responsible for the blood supply of over 70% of the myocardium. It usually arises from the superior margin of the left aortic sinus of Valsalva and then divides into the left anterior descending artery and the left circumflex artery, while a ramus intermedius can be present in almost 30% of cases. Histologically, it differs from the rest of the coronary tree because of the higher elastic fiber content at the level of its ostium. Mean length of the left main is around 10 mm, while the mean diameter is slightly less than 5 mm. As with other bifurcations, the dimensions of its branches can be estimated by Finet's law, as it follows fractal geometry. Significant coronary artery disease affecting the left main is found in approximately 5% of coronary angiographies, more often in men than in women. Isolated left main stenosis is quite rare as compared to its association with one-, two-, and three-vessel disease. Plaque dis..
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