198 research outputs found
Aurelio Rezzonico
No full textBiografia del mercante e collezionista Aurelio Rezzonico (Genova 1619-Venezia 1682
Abbondio Rezzonico senatore di Roma
No full textE' illustrato e analizzato il Ritratto di Abbondio rezzonico, protagonista della cultura romana del secondo Settecento, che costituisce uno dei capolavori della ritrattistica di Pompeo Batoni
1789-’90 Carlo Castone della Torre Rezzonico : Giornale del viaggio di Napoli
No full textConsiderazioni critiche e bibliografiche sul resoconto di viaggio a Napoli di Carlo Castone della Torre di Rezzonico
Il trionfo dell' umiltà : canti quattro pel glorioso ingresso di Sua Eccellenza il signor cavaliere d. Aurelio Rezzonico alla dignità di procuratore di San Marco per merito.
No full textSignatures: pi² A-B⁸ C¹⁰.Etched frontispiece. Four full-page etched ports.: Clement XIII Rezzonico by A. Guera, Cardinal Carlo Rezzonico by F. Vollter(?), Aurelio Rezzonico by Guera, Ludovico Rezzonico by Magnini.Letterpress text on each page printed within etched border. That on t.p. signed by G. Leonardis after F. Fontebasso. Eight etched head- and tail-pieces, that on C7r signed G. Magnini.Dedication signed by Gasparo Gozzi, the author.Mode of access: Internet.Binding: 19th-century blind-stamped red morocco-grained bookcloth. Author & title on spine in gilt.Laid in Getty copy are the original front and back etched paper wrappers, printed in blue-green ink
Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia
No full textLenalidomide is effective against relapsed chronic lymphocytic leukemia (CLL). We report the first case of long-term molecular remission with continuous lenalidomide treatment in a young patient with CLL relapsed to multiple treatments. Minimal residual disease was assessed by nested polymerase chain reaction on bone marrow samples with patient-specific primers. A 20-yr-old patient with standard-risk CLL was treated with lenalidomide after multiple relapses and achieved a 4 yr long complete molecular response with minimal toxicities. Published biologic data support that lenalidomide induces an immune-mediated control of CLL, and our case suggests that long-term treatment with lenalidomide is effective at a molecular level in patients with relapsed CLL
Monitoraggio audiologico della terapia chelante in pazienti affetti da Talassemia Major
No full textI farmaci chelanti possono causare deficit uditivo, un attento monitoraggio audiologico tramite esecuzione periodica di esame audiometrico tonale liminare, vocale ed impedenzometrico, può evidenziare l'eventuale deficit uditivo iniziale, permettendo di modificare la terapia per evitare ulteriore deriva di soglia
Microsurgical reconstruction of oropharynx, lingual and inferior alveolar nerves
No full textAim. Oncological surgery of soft palate and tonsillar fossa often involves resection of lingual and inferior alveolar nerves. Forearm free flap is commonly used to reconstruct this region; moreover, it contains the lateral antebrachial nerve that can be used as interposition graft to reconstruct lingual or inferior alveolar nerves. When both nerves are resected, great auricular nerve can be grafted, too.
Methods. Between April 1995 and March 2004, 8 patients were operated on for tonsillar fossa and soft palate carcinoma and primary reconstruction with forearm free flap was accomplished. Nerve reconstruction by interposition nerve grafts was accomplished. Morpho-functional results were analysed and compared to current literature.
Results. Objective sensitivity and logopedic test and subjective patients' satisfaction questionnaires showed that patients had a discrete recovery of oral functions.
Conclusion. Forearm free flap is the first choice in microsurgical reconstruction of soft palate and tonsillar fossa. It can be shaped and folded to reconstruct the three dimensions of resected region, preserving soft palate function and velo-pharyngeal competence. When lingual and/or inferior alveolar nerve are resected for oncological reasons, interposition nerve grafts with lateral antebrachial or great auricolar nerves allow to restore their function, with better results for patients' quality of life
Digital human modelling method for the evaluation of the ultrasound system and transducer design adherence to the SDMS industry standards
No full textThe problem of work related musculoskeletal disorder (WRMSD) among sonographers is of great importance. The term WRMSD is used to describe conditions that are caused or aggravated by workplace activities. The updated Industry Standards for the Prevention of Work Related Musculoskeletal Disorders in Sonography, published recently by the Society of Diagnostic Medical Sonography (SDMS), recommends a set of points concerning the ergonomics, design and workflow characteristics, which Diagnostic Ultrasound (US) system manufacturers must follow in terms of design and development of the US system console and scanner body, control panel, monitor and transducers. The present work describes an innovative design methodology utilizing Digital Human Modelling (DHM) to simulate the degree of adherence to the SDMS updated Industry Standards for the Prevention of WRMSDs in Sonography of an US system, monitor and transducer design at the Computer aided Design (CAD) level
Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produceprofibrotic chemokines, with partial exploitation of toll-like receptor 4.
No full textObjective. Previous studies have revealed the presence of IgG antifibroblast antibodies (AFAs) capable of binding to the surface of fibroblasts in systemic sclerosis (SSc) sera. Since chemokines may directly or indirectly affect the development of fibrosis, this study was undertaken to investigate the production of chemokines induced by AFAs in fibroblasts, and to characterize the signaling pathways and surface molecules involved. Methods. AFA-positive and AFA-negative IgG were tested on fibroblasts. Chemokine messenger RNA expression was screened by microarray and quantitative reverse transcription-polymerase chain reaction. Production of CCL2, CXCL8, and CXCL10 proteins was assessed by enzyme-linked immunosorbent assay. Pharmacologic inhibitors were used to study signal transduction, with results assessed by Western blotting and immunofluorescence analysis. Fibroblasts with defective expression of Toll-like receptors (TLRs) and anti-TLR monoclonal antibodies (mAb) were used to assess AFA specificity. Results. In human fibroblasts, AFA-positive IgG induced the preferential transcription of chemokines with profibrotic and proangiogenic potential, including, but not exclusively, CCL2, CXCL1, CXCL8, CKLF, and ECGF1, which were distinctly different from those induced by interferon-γ. Levels of CCL2 and CXCL8 proteins were increased in AFA-stimulated fibroblast culture supernatants. AFA binding to fibroblasts resulted in concomitant activation of ERK-1/2, c-Jun, and NF-κB. CCL2 production was sensitive to inhibition of both proteasome and JNK, while CXCL8 production was sensitive only to inhibition of proteasome. AFAs failed to up-regulate CCL2 expression in TLR-4-deficient fibroblasts but not in TLR-6- or TLR-2-deficient fibroblasts. Moreover, anti-TLR-4 mAb, but not anti-TLR-2 mAb, partially inhibited the production of CCL2 induced by AFAs in human fibroblasts. Conclusion. Autoantibodies that bind to the surface of fibroblasts may contribute to the pathogenesis of SSc by up-regulating the fibroblast production of profibrotic and proangiogenic chemokines, in a proteasome- and TLR-4-dependent manner
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