1,721,016 research outputs found
Long-term Effects of Vagus Nerve Stimulation in Treatment- resistant Depression : a 5-years Follow up Cases Series
No full textCurrent and future perspectives on vagus nerve stimulation in treatment-resistant depression
No full textIl litio e gli anticonvulsivanti: gli anticonvulsivanti e il loro utilizzo in psichiatria
No full textCorrosion failure analysis of galvanized steel pipes in a closed water cooling system
No full textThe present study is focused on the corrosion failure analysis of a water cooling system serving a polyethylene terephtalate (PET) preform molding plant. Piping mainly located both after the water pretreatment and in the injection molding machines was affected by an extensive corrosion phenomenon and several leakages of coolant occurred, involving the risk of loss of functionality of the whole plant. The main problem detected in closed cooling circuits was a marked modification of the water chemistry and a great amount of metal ions leading to recurring fouling of the inner surfaces of molds and cooling channels. Analysis of water flowing in the closed cooling circuit operating at 6 °C revealed a very high amount of metals in the flowing water and in the sediment (zinc and iron). Moreover the water pH was slightly acidic. Data were compared with water from supply well. Preliminary electrochemical characterization was carried out on galvanized steel pipe, in order to evaluate the aggressiveness of water both from the cooling circuits and from the supply wells. The results of laboratory analysis together with the scrutiny of the available technical documentation showed that the damage of the plant was the consequence of an inadequate plant management, mainly for what concerns materials selection and water chemical treatment
The Noradrenergic Action in Antidepressant Treatments : Pharmacological and Clinical Aspects
No full textEven though noradrenaline has been recognized as one of the key neurotransmitters in the pathophysiology of major depression (MD), noradrenergic compounds have been less extensively utilized in clinical practice, compared to selective serotonin reuptake inhibitors (SSRIs). The development of the first selective noradrenergic reuptake inhibitor (NRI), Reboxetine, has not substantially changed the state of the art. In addition, Atomoxetine, a relatively pure NRI used for the treatment of ADHD, has shown mixed results when administered in augmentation to depressed subjects. Through a Medline search from 2000 to 2010, the present article provides an updated overview of the main pharmacological and clinical aspects of antidepressant classes that, partially or selectively, act on the noradrenergic systems. The noradrenergic action plays an important clinical effect in different antidepressant classes, as confirmed by the efficacy of dual action antidepressants such as the serotonin noradrenaline reuptake inhibitors (SNRIs), the noradrenergic and dopaminergic reuptake inhibitor (NDRI) Bupropion, and other compounds (e.g., Mianserin, Mirtazapine), which enhance the noradrenergic transmission. In addition, many tricyclics, such as Desipramine and Nortriptyline, have prevalent noradrenergic effect. Monoamine oxidase inhibitors (MAOIs), moreover, block the breakdown of serotonin, noradrenaline, dopamine and increase the availability of these monoamines. A novel class of antidepressantsthe triple reuptake inhibitorsis under development to selectively act on serotonin, noradrenaline, and dopamine. Finally, the antidepressant effect of the atypical antipsychotic Quetiapine, indicated for the treatment of bipolar depression, is likely to be related to the noradrenergic action of its metabolite Norquetiapine. Even though a pure noradrenergic action might not be sufficient to obtain a full antidepressant effect, a pronoradrenergic action represents an important element for increasing the efficacy of mixed action antidepressants. In particular, the noradrenergic action seemed to be related to the motor activity, attention, and arousal
Studi immunologici e citogenetici sui linfociti di bovini normali o con linfocitosi persistente
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