1,120 research outputs found
Efficacy of bortezomib, lenalidomide and dexamethasone(VRD) in secondary plasma cell leukaemia
No full textPlasma cell leukaemia (PCL) is characterized by circulating
plasma cells >2 9 109/l in peripheral blood and/or a peripheral
blood plasmacytosis >20%. Primary PCL (pPCL) is
defined as a de novo appearance of disease, while secondary
PCL (sPCL) corresponds to the leukaemic transformation of
a previously diagnosed multiple myeloma (MM) (Albarracin
& Fonseca, 2011). sPCL still remains an exceedingly resistant
disease with median survivals of 2 months (Tiedemann et al,
2008; Musto et al, 2011a; Pagano et al, 2011). Lenalidomide
has been reported to have some activity’ in sPCL although it
is short-lived (Benson & Smith, 2007; Musto et al, 2008),
while better results have been described when this drug is
used as first line therapy in pPCL (Musto et al, 2011b). Bortezomib
has been investigated with promising results as single
agent or in combination both in pPCL and sPCL
EL CASO DE LOS VERBOS HABER/TENER Y AVERE/TENERE EN ESPAÑOL Y NAPOLITANO EN SU EVOLUCIÓN DIACRÓNICA: ¿CALCO SEMÁNTICO-SINTÁCTICO O CONVERGENCIA SEMÁNTICO-SINTÁCTICA CONGÉNITA?
No full textA lo largo de los siglos, la península ibérica e Italia han interactuado de maneras únicas,
tanto a través de intercambios comerciales como de conquistas y migraciones. La presencia del Imperio Español en el Mediterráneo llevó a un intenso intercambio cultural y lingüístico entre las dos regiones, dejando huellas de influencias mutuas que muestran una similitud que va más allá de la coincidencia casual. Sin embargo, a pesar de las similitudes, no siempre atribuibles al contacto entre los dos idiomas, es importante subrayar que, aunque las lenguas romances pertenecen a un mismo tronco lingüístico y cultural, los desarrollos que llevan a adoptar las mismas soluciones lingüísticas pueden ser a veces el resultado de un camino proprio estrechamente ligado a su diversidad cultural y al espacio geográfico habitado por cada una de ellas.
El siglo XVI, en el que Nápoles pasa a estar bajo la Corona Española, fue un período rico y significativo para la historia de toda Italia meridional. La dominación española dejó una huella indeleble no solo en la ciudad, influyendo en diversos aspectos de la vida, incluida la lengua, sino en todo el sur de la península italiana. Sin embargo, atribuir exclusivamente el parecido entre el napolitano y el español a este período podría resultar demasiado simplista y llevar a conclusiones engañosas.
Por tanto, resulta esencial ampliar el marco temporal para examinar las raíces comunes que han dado forma a la conexión lingüística entre español y napolitano, una conexión influenciada por siglos de evolución independiente, contactos culturales y sociales
\u3ci\u3eControl and Protect: Collaboration, Carceral Protection, and Domestic Sex Trafficking in the United States\u3c/i\u3e by Jennifer Musto
No full textReview of Jennifer Musto\u27s Control and Protect: Collaboration, Carceral Protection, and Domestic Sex Trafficking in the United States. Berkeley and Los Angeles: University of California Press, 2016
Monoclonal B-cell lymphocytosis
No full textMonoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenotypic profile of clonal B-cells, the majority of MBL cases (75%) are classified as chronic lymphocytic leukemia (CLL)-like. This form may progress into CLL at a rate of 1–2% per year. It is thought that CLL is always preceded by MBL. The remaining MBL cases are defined as atypical CLL-like (CD5+/CD20bright) and CD5- MBL. The MBL clone size is quite heterogenous. Accordingly, two forms of MBL are identified: i) high-count, or ‘clinical’ MBL, in which an evidence of lymphocytosis (<5 x 109/L clonal B-cells) is seen, and ii) a low-count MBL, in which a normal leukocyte count is found and that is identified only in population-screening studies. Both forms of MBL may carry the cytogenetic abnormalities that are the hallmark of CLL, including 13q-, 17p- and trisomy 12. Consistent with the indolent phenotype of this condition, genetic lesions, such as TP53, ATM, NOTCH1 and SF3B1 mutations, usually associated with high-risk CLL, are rarely seen. Overall, no prognostic indicator of evolution of MBL to overt CLL has been found at present time. However, taking into account this possibility, a clinical and lab monitoring (at least annually), is recommended
Experimental Investigation of Natural Convection in an Asymmetrically Heated Vertical Channel with an Asymmetric Chimney
No full textAn experimental investigation on air natural convection, in a vertical channel asymmetrically heated at uniform heat flux, with downstream unheated parallel extensions, is carried out. One extension is coplanar to the unheated channel wall and the distance between the extensions is equal to or greater than the channel gap (geometrically asymmetric chimney). Experiments are performed with different values of the wall heat flux, aspect ratio (L-h/b), extension ratio (L/L-h) and expansion ratio (B/b). For the largest value of the aspect ratio (L-h/b = 10), the adiabatic extensions improve the thermal performance in terms of lower maximum wall temperature of the channel. Optimal configurations of the system with asymmetrical chimney are detected. Flow visualization shows a cold inflow in the channel-chimney system that penetrates down below the channel exit section. Maximum wall temperatures and channel Nusselt numbers are correlated to the channel Rayleigh number Ra*, and to the geometrical parameters, in the ranges 3.0 X 10(2) <= Ra*B/b <= 1.010(5), 1.0 <= B/b <= 3.0 and 1.0 <= L/L-h <= 4.0 with L-h/b =5.0 and 10.0
Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events
No full textLin28 RNA-binding proteins play important roles in pluripotent stem cells, but the regulation of their expression and the mechanisms underlying their functions are still not definitively understood. Here we address the above-mentioned issues in the first steps of mouse embryonic stem cell (ESC) differentiation. We observed that the expression of Lin28 genes is transiently induced soon after the exit of ESCs from the naive ground state and that this induction is due to the Hmga2-dependent engagement of Otx2 with enhancers present at both Lin28 gene loci. These mechanisms are crucial for Lin28 regulation, as demonstrated by the abolishment of the Lin28 accumulation in Otx2- or Hmga2-knockout cells compared to the control cells. We have also found that Lin28 controls Hmga2 expression levels during ESC differentiation through a let-7-independent mechanism. Indeed, we found that Lin28 proteins bind a highly conserved element in the 3' UTR of Hmga2 mRNA, and this provokes a down-regulation of its translation. This mechanism prevents the inappropriate accumulation of Hmga2 that would modify the proliferation and physiological apoptosis of differentiating ESCs. In summary, we demonstrated that during ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.-Parisi, S., Passaro, F., Russo, L., Musto, A., Navarra, A., Romano, S., Petrosino, G., Russo, T. Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events
How to contrast and maintain information in Spanish and Italian, as L1s and L2s
No full textThe purpose of the paper is to analyse the way informants change or contrast information in the Topic Entity and Topic Time domains (Klein 2008) in Italian and Spanish, as L1s and L2s. In the narrative task proposed, informants also have to maintain predicative information, since a process claimed to hold for some Topic Entities and Topic Times is actually ma
intained from previous discourse.
The data have been elicited using the video clip The Finite Story (Dimroth 2006) and are divided in four groups: Spanish L1, Italian L1, Spanish L2 of Italian learners, Italian L2 of Spanish learners.
Dimroth et al. (2010) have analysed Finite Story narrations of German, Dutch, French and Italian adult native speakers, identifying the type of items signalling which parts of the information are maintained and which parts have been changed or contrasted. The anaphoric linking devices range from additive particles to polarity or temporal contrasting markings and to prosodic devices. The same authors suggest that: when a polarity contrast is present, Dutch and German mark this polarity contrast much more frequently than Romance languages, which prefer to mark the contrast on the topic component (entity or time).
Benazzo & Andorno (2010) extended the debate to Italian and French as L2s. Giuliano (2012) tested Dimroth et al.’s hypothesis on English, both as L1 and L2 (all the author used The Finite Story task), suggesting that English native speakers select cohesive means much closer to those preferred by Romance than Germanic speakers. All the authors explored crosslinguistic interferences.
Now, our purpose in the present paper is to furtherly extend the debate to Spanish, as L1 and L2, and to Spanish of Italian learners. We shall demonstrate that Spanish is in many ways closer to Germanic than to Romance languages since its native speakers tend to often highlight the polarity contrast, despite the absence in their L1 of specifically grammaticised means for this purpose; they also tend to transfer this type of contrast in Italian L2, whereas the polarity contrast is absent in the Spanish L2 of Italian speakers.
Bibliography
Benazzo, S. & Andorno, C. 2010. Discourse cohesion and topic discontinuity in native and learner production: changing topic entities on maintained predicates. In L. Roberts, M. Howard, M. O'Laoire & D. Singleton (éds.) Eurosla Yearbook 10 (92-118). Amsterdam: John Benjamins.
Dimroth, Christine, 2006. The Finite Story. Max-Planck-Institute for Psycholinguistics, http://corpus1.mpi.nl/ds/imdi_browser?openpath=MPI560350%23
Dimroth, Christine / Andorno, Cecilia / Benazzo, Sandra / Verhagen, Josie (2010), “Given claims about new topics. The distribution of contrastive and maintained information in Romance and Germanic Languages”, Journal of Pragmatics 42: 3328-3344.
Giuliano, P. (2012), “Contrasted and maintained information in a narrative task: analysis of texts in English and Italian as L1s and L2s”, EUROSLA Yearbook 2012, Amsterdam, John Benjamins, vol. 12: 30-62.
Klein, Wolfgang, 2008, “The topic situation”. In: Ahrenholz, B. et al. (Eds.), Empirische Forschung
und Theoriebildung. Festschrift für Norbert Dittmar zum 65. Geburtstag. Frankfurt a.M., Peter Lang, pp. 287-306
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