1,783 research outputs found
The poetics of being
No full textThe aim of The Poetics of Being is to inquire into how the apperception of the Being of beings is produced. We will recognize this production not primarily in philosophy, but in a medium accessible to us all, theatre. Although the Romantic tradition of literary criticism from Herder to Bloom has noted that Shakespeare produces an exceptional sense of what is [true], so much so that he is said to create the impression of nature or life, no one has so far attempted to show how precisely Shakespeare affects this experience. Contrary to T. S. Eliot, who is unable to discern any kind of poetics in Shakespeare's plays, we have discovered an insistent and consistent pattern of inadequation, a kind of mismatch. The thesis argues, that the predominant tropes of inadequation are falsity, dissimilarity, nothing, indefinition, elision and substitution. We shall show that these figures of inadequation are the universal means by which Shakespeare, almost imperceptibly, compels the spectator to infer the apperception of what is [true].
On the basis of these tropes of inadequation the thesis makes the fundamental philosophical claim that the cognition of Being through non-Being is a negative form of what Heidegger calls the ontological difference. We call this the negative ontological difference. The thesis demonstrates that with the exception of some Pre-Socratic thinkers, Plato in the Sophist, the work of Pseudo-Dionysius, and the writings of Derrida, the bulk of the tradition of Western philosophy has argued Being in terms of positivities. While the thesis does not question the possibility of realizing the ontological difference in a positive fashion, as does Heidegger's philosophy of unconcealment, the thesis claims that the negative ontological difference, or ontological contradiction, is the more forceful process by which we become aware of what is [true]
C0 or C2 driven cyclosporine monitoring in long-term pediatric kidney transplant recipients : Is there any threat for chronic rejection development?
No full textThe clinical management of cyclosporine has evolved greatly during the last decade thanks to the use of pharmacokinetic (PK) studies which confirmed the dose relationship between drug exposure and its biological effects. Therefore, cyclosporine PK monitoring during the early phase of the post-transplant period became essential to avoid over or underexposure to the drug thus preventing the risk of nephrotoxicity or acute rejection episodes. More recently, a simple PK determination based on cyclosporine blood concentration measured 2 h after the morning dose, has proven to be very effective for monitoring cyclosporine exposure in the early postoperative period. In this paper, the authors present a set of PK profiles obtained from a stable, long-term pediatric kidney transplant population and correlate these parameters with the risk of chronic rejection development. The study shows how cyclosporine monitoring based on the sole trough level determination misled a correct therapeutic behavior, as revealed by the PK parameters that were constantly below the therapeutic threshold in a small patient cohort who eventually developed chronic rejection. The C2 determination should be considered as the gold standard for cyclosporine monitoring in long-term pediatric recipients. (copyright) 2005 Blackwell Munksgaard
Crystallographic characterization of geometry and conformation of TOAC, a nitroxide spin-labelled C-alpha,C-alpha-disubstituted glycine, in simple derivatives and model peptides
No full textThe molecular and crystal structures of one derivative and two oligopeptides of TOAC, a nitroxide spin-labelled C-alpha,C-alpha-disubstituted glycine, have been determined by X-ray diffraction. The derivative is the 5(4H)-oxazolone from Piv-TOAC-OH; the oligopeptides are Z-TOAC-(L-Ala)(2)-NHtBu sesquihydrate and pBrBz-TOAC-(L-Ala)(2)-TOAC-L-Ala-NHtBu hemihydrate. Incipient and fully developed right-handed 3(10)-helical conformations are formed by both independent molecules in the asymmetric unit of the terminally blocked tripeptide amide and the terminally blocked pentapeptide amide, respectively. The average geometry and preferred conformation for the piperidine ring of the TOAC residues are also discussed in detail. (C) Munksgaard 1996
Nanotechnology and its role in the management of periodontal diseases
No full textCopyright © 2006 Blackwell Munksgaard The definitive version is available at www.blackwell-synergy.comLing Xue Kong, Zheng Peng, Si-Dong Li & P. Mark Bartol
HARNESSING D-AMINO ACIDS FOR PEPTIDE MOTIF DESIGNS - SYNTHESIS AND SOLUTION CONFORMATION OF BOC-D-GLU-ALA-GLY-LYS-NHME AND BOC-L-GLU-ALA-GLY-LYS-NHME
No full textIn examining the use of D-amino acids in designing specific peptide folding motifs, the tetrapeptide Boc-D-Glu-Ala-Gly-Lys-NHMe 1 and its analog 2 featuring L-Glu were synthesized for a comparison of their solution conformations by NMR spectroscopy. The temperature coefficients of amide proton resonances, NOE data, side-chain CH2 anisotropies and salt titration results suggest a weak type II reverse-turn conformation for peptide 2, and a tandem type II' turn-3(10)-helix conformation of appreciable conformational stability for peptide I in apolar solvents. The latter is of potential interest as the N-terminal helix cap that could support the design of longer 3(10) helices. Possible origins of appreciable difference in the conformational stabilities of the diastereomers are discussed. (C) Munksgaard 1994
Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens
No full textThe present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, beta-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to beta-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from < or = 0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides
Familial iridogoniodysgenesis and skeletal anomalies: a probable new autosomal recessive disorder
No full textThree sibs with congenital glaucoma, skeletal anomalies, and peculiar facial appearance were studied. At birth, enlarged eyes and corneae were present in the proposita and her two brothers due to congenital glaucoma secondary to iridogoniodysgenesis (IGD). The purpose of this article is to describe the second familial case with IGD and skeletal anomalies as the family previously described by Garc� a-Cruz et al. in 1990, corroborating this new distinct dysmorphic syndrome with probable autosomal recessive inheritance. � Blackwell Munksgaard, 2004
Parent – environmental interactions shape acoustic signatures in tree swallows: a cross-fostering experiment.
No full textAcoustic signatures are common components of avian vocalizations and are important for the recognition of individuals and groups. The proximate mechanisms by which these signatures develop are poorly understood, however. The development of acoustic signatures in nestling birds is of particular interest, because high rates of extra-pair paternity or egg dumping can cause nestlings to be unrelated to at least one of the adults that are caring for them. In such cases, nestlings might conceal their genetic origins, by developing acoustic signatures through environmental rather than genetic mechanisms. In a cross-fostering experiment with tree swallows Tachycineta bicolor, we investigated whether brood signatures of nestlings that were about to fledge were attributable to their genetic/maternal origins or to their rearing environment. We found that the calls of cross-fostered nestlings did not vary based on their genetic/maternal origin, but did show some variation based on their rearing environment. Control nestlings that were not swapped, however, showed stronger brood signatures than either experimental group, suggesting that acoustic signatures develop through an interaction between rearing environment and genetic/maternal effects
Long-term treatment with zidovudine in patients with human immunodeficiency virus (HIV)-associated thrombocytopenia : modes of response and correlation with markers of HIV replication
No full textThe effects of zidovudine on the platelet count were studied in 152 patients with HIV-related thrombocytopenia of severe grade (platelet count 50 x 10(9)/l). In both groups of patients there was a significant increase in the mean platelet count from the baseline value, after 2 weeks (from 21 x 10(9)/l to 48 x 10(9)/l and from 75 x 10(9)/l to 97 x 10(9)/l) and 3 months of therapy (to 59 x 10(9)/l and to 144 x 10(9)/l). Sixty-five and 39 patients were followed up for 12 and 18 months, respectively, and the mean platelet values after 12 and 18 months of therapy were still significantly increased, compared to the respective mean baseline values, in both groups of patients. Clinical progression of the disease was observed in 23 treated patients, none of them showing concomitant reductions of the platelet number. An increase in the mean CD4+ cell count after 3 months of therapy was followed by a progressive decline in the 65 patients with a 12-month follow-up, while no significant changes of the p24 antigenemia rates were observed after 1 year of therapy in 53 patients evaluated. The long-term effects of zidovudine on the platelet count, but not on other parameters of clinical outcome, might be explained by the involvement of specific mechanisms in the pathogenesis of this kind of thrombocytopenia and of its response to zidovudin
Apparent contradiction between negative effects of UV radiation and positive effects of sun exposure
No full textWe would like to comment on the three contributions in the Journal of the National Cancer Institute, Vol. 97, No. 3, February 2, 2005: Kathleen M. Egan, Jeffrey A. Sosman, William J. Blot: Editorial: Sunlight and Reduced Risk of Cancer: Is the Real Story Vitamin D? (pp. 161-163) ; Marianne Berwick, Bruce K. Armstrong, Leah Ben-Porat, Judith Fine, Anne Kricker, Carey Eberle, Raymond Barnhill: Sun Exposure and Mortality From Melanoma. (pp. 195-199) ; Karin Ekström Smedby, Henrik Hjalgrim, Mads Melbye, Anna Torrång, Klaus Rostgaard, Lars Munksgaard, et al.: Ultraviolet Radiation Exposure and Risk of Malignant Lymphomas. (pp. 199-209)
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