1,257 research outputs found
I processualisti civili - Crisanto Mandrioli
No full textIl contributo delinea la figura scientifica ed accademica del prof. Crisanto Mandrioli, presentandone le principali opere scientifiche
Advances in Object Oriented Software Engineering
No full textThe book consists of nine chapters:
Design by contract, by B. Meyer;
The new culture of software development, by B. Meyer;
An object oriented approach to domain analysis, by S. Shlaer and S. Mellor;
Active software objects in a knowledge-based software life cycle support environment, by A. Van Lamsweerde;
On eclectic specification envirnments, by C. Ghezzi and D. Mandrioli;
Distributed software design techniques, by M. Jazayeri;
A tour of Hybrid, by O. Nierstrasz;
An object-oriented architecture for real-time applications, by L. Nigro and F. Tisato;
A development in Eiffel, by C. Gindre and F. Sada
Correction to: Italian version of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS): validation and longitudinal performance (Journal of Neurology, (2023), 270, 3, (1452-1456), 10.1007/s00415-022-11483-3)
No full textThe original version of this article unfortunately contained a mistake. The affiliation details for Author ‘’Jessica Mandrioli’’ were incorrectly given as ‘’Neuromuscular Center, S. Bortolo Hospital, Vicenza, Italy’’ but should have been: Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of Neuroscience, Neurology Unit, S. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy
Ultrastructural findings of spontaneously occurring seminoma in an adult ornamental cyprinid (Cyprinus carpio L.)
No full textAn ultrastructural description of a previously described spontaneous seminoma in a Koi carp (Cyprinus carpio) is given in this note. The seminoma, diagnosed as classical with a diffuse pattern by histology and immunohistochemistry, displayed a homeomorphic population of neoplastic cells with ultrastructural features similar to those described in human seminoma
The role of pathologist in the diagnosis of fish diseases
No full textdescrivere l'importanza ed i limiti delle metodiche anatomo-patologiche per la diagnosi delle più comuni malattie ittiche. Necessità di effettuare un approccio integrato con le altre discipline.
Il workshop non ha previsto il rilascio di atti, ma solo di una stampa del foglio in pagina unica contenente il programma della giornata
Celomatic neoplasm in a Cyprinid
No full textThe animal was a 3-year old male koi carp (Cyprinus carpio), 28-cm long. The first two years (2006-2008) the animal was kept in a farm with natural reproduction in a backyard pond in Italy. Afterwards the koi was kept for one year with other koi in a pet-shop in a 1.500 liter tank with a water recirculation system and standard filtration system. The fish was fed a commercial pellet diet and had not been treated with chemicals during the maintenance in the tank. On May 2008, the animal started showing lethargy of one month duration. One week before death the koi presented with anorexia and abdominal enlargement. Shortly after death the animal was send to the Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Bologna for further investigation.
Macroscopically, the koi showed epaxial muscle atrophy, especially in the caudal part of the body, and a symmetric abdominal enlargement. The skin overlaying the enlargement was thinned and missed scales. At necropsy, a multinodular, 7x5x3,5 cm, ventral to the kidney and to the swim bladder, white-yellowish, firm mass, filling the celomatic cavity, was identified. The mass was in strict connection with the liver and some parts of the intestine. The kidney, gall bladder, swim bladder and parts of the intestine were not involved. Gonads were not recognizable (Fig.1).
Histologically, the neoplasm was non-encapsulated, poorly demarcated, multilobulated, highly cellular, with invasive growing and was characterized by a lobular architecture with abundant fibro-connective septa and large necrotic and calcified areas. Lobules were composed of solidly, cellular sheets of neoplastic polygonal cells, supported by fine fibrovascular stroma (Fig.2). Within some normal residual seminiferous tubules, small aggregates of 3-5 μm, round basophilic cells referred to spermatids were present (Fig.3).
The neoplastic cells were 10-15 μm large, with not well-demarcated cytoplasmic boundaries; the cytoplasm presented numerous and thin granulations; the nucleus was large, round, hypochromatic and centrally located, with scattered chromatin and a single nucleolus (Fig.4). There was moderate anisocytosis and anisokaryosis. The mitotic rate was low (<1/ high power field). In the stroma scattered clusters of lymphocytes and melanomacrophages were present. Neoplastic cells massively infiltrated the intestinal wall and the liver (Fig.5, 6). Moreover, neoplastic lobules compressed the hepatic parenchyma causing atrophy (Fig.7). Neoplastic cells were PAS-negative.
Immunohistochemically, normal seminiferous cells displayed an immunoreactivity to PLAP, vimentin and catalase, while the stromal component cross-reacted with cytokeratin AE1/AE3.
The signal was not detected concerning the remaining antibodies tested (alpha feto protein, estrogen receptor, NSE, calretinin).
Based on the macroscopic findings and the morphological features, the tumor was diagnosed as seminoma with a diffuse pattern. The evident malignancy was supported by the neoplastic cells invasion through the intestinal wall and the liver
Seminoma in a koi carp Cyprinus carpio: histopathological and immunohistochemical findings
No full textA spontaneous seminoma in a 3 yr old male koi carp Cyprinus carpio L. is described. The animal, presenting a symmetric abdominal enlargement, showed a celomatic multinodular, white-yellowish and firm mass that infiltrated the liver and the intestine wall. Histologically, the neoplasm was non-encapsulated and poorly demarcated, showed invasive growth and was characterized by a lobular architecture, subdivided by abundant fibro-connective septa. Large necrotic and calcified areas together with small aggregates of residual spermatids were present. We diagnosed a classical seminoma with a diffuse pattern. Neoplastic cells cross-reacted with vimentin, placental alkaline phosphatase, and c-KIT. An immunohistochemical phenotypization of the tumor was performed to exclude other celomatic neoplasms and to compare this seminoma with those reported in mammals and humans
Discontinued anxiolytic drugs (2009-2014)
No full textAnxiety is a complex psychiatric disorder with an unknown aetiology and involving several neurotransmitter systems. These constraints have meant that researchers have looked to develop drugs, which target a variety of molecular targets, with the aim of creating safer and more effective anxiolytic drugs. Apart from the 'traditional' GABAergic and serotonergic systems, the endocannabinoid, opioidergic, glutamatergic, neurokinin, and even cholinergic systems have been (and are being) considered as preferred targets for prospective new drugs
L’accertamento dell’età dei minori stranieri non accompagnati in Italia e il diritto internazionale: dalla legge Zampa alle recenti novità promosse dal Governo
No full textIl presente lavoro analizza, sotto un profilo giuridico internazionale, le recenti novità legislative in tema di accertamento dell’età dei minori stranieri non accompagnati previste dal d. l. n. 133 del 2023, successivamente convertito nella legge n. 176 del 2023. L’intervento del Governo italiano, promosso al fine di fronteggiare una situazione di emergenza nella gestione dei flussi migratori, introduce una serie di rilevanti novità che destano non poche perplessità con riferimento alla loro ottemperanza rispetto a quanto previsto dal diritto internazionale. Al netto di brevi considerazioni introduttive, il lavoro esordisce descrivendo le tecniche di accertamento dell’età utilizzate in epoca contemporanea, soffermandosi in particolare sulla loro rilevanza da un punto di vista giuridico nazionale, europeo e internazionale. Le seguenti pagine sono dedicate all’analisi del quadro normativo in materia vigente in Italia prima della suddetta riforma. La disciplina recentemente introdotta dal Governo verrà successivamente descritta, riservando, invece, alle ultime due sezioni dello scritto il compito di analizzare criticamente tale intervento sotto un profilo giuridico internazionale, e, infine, di riportare alcune considerazioni conclusive del lavoro svolto
DNA methylation in insects
No full textCytosine DNA methylation has been demonstrated in numerous eukaryotic organisms and has been shown to play an important role in human disease. The function of DNA methylation has been studied extensively in vertebrates, but establishing its primary role has proved difficult and controversial. Analysing methylation in insects has indicated an apparent functional diversity that seems to argue against a strict functional conservation. To investigate this hypothesis, we here assess the data reported in four different insect species in which DNA methylation has been analysed more thoroughly: the fruit fly Drosophila melanogaster, the cabbage moth Mamestra brassicae, the peach-potato aphid Myzus persicae and the mealybug Planococcus citri
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