158 research outputs found
Episome generated antisense suppression of N myc expression blocks morphologic differentiation of a human neuroepithelioma cell line
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EFFECT OF OVER-EXPRESSION OF BACTERIAL RIBONUCLEASE-H ON THE UTILITY OF ANTISENSE MYC OLIGODEOXYNUCLEOTIDES IN THE MONOCYTIC LEUKEMIA-CELL LINE-U937
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Monoclonal antibody characterization of interferon type I receptors in neuroendocrine tumor cell-lines
No full textAntisense inhibition of N-myc reduces cell growth but does not affect C-myc expression in CHP100 cell line
No full textModulation of brain tryptophan hydroxylase activity by brain tryptophan content
No full textNECKERS, L. M., G. BIGGI0, E. MOJA AND J. L. MEEK: Modulation of brain tryptophan hydroxylase activity by brain tryptophan content. J. Pharmacol. Exp. Ther. 201: 110-116, 1977. Although hydroxylation oftryptophan (TP) is considered to be the rate-limiting step in serotonin synthesis, the mechanism whereby tryptophan hydroxylase (TPH) partici-pates in the regulation of serotonin synthesis is still in question. Since the brain TP concentration is probably near the Km for tryptophan hydroxylase, changes in brain TP content could affect the rate of its hydroxylation. However, it has not been established whether in vivo the activity ofTPH changes with changes in TP concentra-tion. In this paper we have made use of high pressure liquid chromatography coupled with fluorescence detection to measure TPH and TP in several brain nuclei and other regions of rat brain after treatments known to lower brain TP levels. Chlorimipra-mine, loading with neutral amino acids and a TP-deficient diet decreased the TP content of some, but not all, brain regions studied. Whenever TP content was de
Reduction of myc protein results in decreased tumorigenesis of the neuroephitelioma cell line CHP100 in an athimic murine xenograft model
No full textAntisense inhibition of N-myc translation in cell free system and a human neuroblastoma cell line
No full textDesign, synthesis, and properties of new derivatives of pentacene
No full textStable, soluble ethynylated derivatives of pentacene (9a-c) were synthesized, and the ethynyl moieties on the terminal rings were used to tune the electronic properties of these compounds. Their oxidation potentials are higher and their reduction potentials are lower than those of pentacene. The HOMO-LUMO gaps are among the lowest reported for pentacene derivatives. © 2006 American Chemical Society.Anthony JE, 2001, J AM CHEM SOC, V123, P9482, DOI 10.1021-ja0162459; Anthony JE, 2002, ORG LETT, V4, P15, DOI 10.1021-ol0167356; BROCK CP, 1990, ACTA CRYSTALLOGR B, V46, P795, DOI 10.1107-S0108768190008382; Chan SH, 2005, CHEM COMMUN, P66, DOI 10.1039-b411831f; Dimitrakopoulos CD, 1998, SYNTHETIC MET, V92, P47, DOI 10.1016-S0379-6779(98)80021-0; Funk RL, 1996, J AM CHEM SOC, V118, P3291, DOI 10.1021-ja9521482; Gundlach DJ, 1997, IEEE ELECTR DEVICE L, V18, P87, DOI 10.1109-55.556089; Holmes D, 1999, CHEM-EUR J, V5, P3399, DOI 10.1002-(SICI)1521-3765(19991105)5:113399::AID-CHEM33993.0.CO;2-V; Klauk H, 2000, SOLID STATE TECHNOL, V43, P63; Maliakal A, 2004, CHEM MATER, V16, P4980, DOI 10.1021-cm049060k; Meng H, 2003, ADV MATER, V15, P1090, DOI 10.1002-adma.200304935; Miller GP, 2000, ORG LETT, V2, P3983, DOI 10.1021-ol0064720; Nelson SF, 1998, APPL PHYS LETT, V72, P1854, DOI 10.1063-1.121205; Ostroverkhova O, 2005, J APPL PHYS, V98, DOI 10.1063-1.1949711; Payne MM, 2004, ORG LETT, V6, P1609, DOI 10.1021-ol049593z; Perepichka DF, 2003, J AM CHEM SOC, V125, P10190, DOI 10.1021-ja036193i; PONOMAREV VI, 1976, KRISTALLOGRAFIYA+, V21, P392; Pope M, 1999, ELECT PROCESSES ORGA; RIED W, 1953, ANGEW CHEM-GER EDIT, V65, P601, DOI 10.1002-ange.19530652309; Sakamoto Y, 2004, J AM CHEM SOC, V126, P8138, DOI 10.1021-ja0476258; SONOGASHIRA K, 1975, TETRAHEDRON LETT, V50, P4467; Swartz CR, 2005, ORG LETT, V7, P3163, DOI 10.1021-ol050872b; Terekhov DS, 1996, J ORG CHEM, V61, P3034, DOI 10.1021-jo9521662; Wurthner F, 2001, ANGEW CHEM INT EDIT, V40, P103746494
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