539 research outputs found
Conférence sur le fonds d’archives audiovisuelles Slon/Iskra : « Du bon usage des épluchures », archives cinématographiques et pratiques militantes
No full textJournée d'études proposée par les Archives départementales de la Seine-Saint-Denis le 23 novembre 2011 à 14h : Slon/Iskra produit et distribue des films militants et des documentaires à dimension sociale depuis 1968. Ses archives ont été déposées aux Archives départementales de la Seine-Saint-Denis. A l’aide de la projection d’extraits issus du fonds Slon/Iskra et de témoignages, nous reviendrons sur l’histoire de la structure qui a permis la constitution d’un fonds audiovisuel aussi vaste. L..
Spontaneous music : the first generation British free improvisers
No full textThe British free improvisation scene originated in London and Sheffield during the
mid 1960s. In groups such as AMM, the Spontaneous Music Ensemble and Joseph
Holbrooke, a distinctive and ambitious musicality developed that still occupies most
of its protagonists forty years later.
Marked stylistic contrasts developed within the genre, notably the `atomistic' and
`laminar' methods of interaction. Nonetheless, a consistency of principle and practice
was also apparent that defined British free improvisation as unique. In some respects
the genre resembled its German, Dutch and American counterparts, and also the jazz
and classical avant-gardes that had inspired them. Both conceptually and practically,
however, clear differences remained.
The British free improvisers refined a method and an aesthetic of musical creativity,
which suggested an intimate perspective and a detailed analysis of that which we
accept as `music'. Its techniques and results were unconventional, but remained
consistent with music's defining concepts and experiences. As such, British free
improvisation suggested a more inclusive model of musicality than is common, and
implied a broad critique of the cultural values that define `music' at all. Though the
free improvisers themselves did not explicitly state the connection, their work may be
viewed in the context of Deconstruction: the post-structuralist analytical strategy
associated with philosopher Jacques Derrida.
British free improvisation culminated from innovations within the twentieth century
avant-garde. Referencing styles such as atonality and free jazz, it challenged the
aesthetic, technical and hierarchical standards of Western tradition in a form that was
striking and extreme, but also of logical development and focus. Free improvisation
owed explicit debt to a variety of other musics; its most singular achievement
however, was the redefinition of `rhythm' by which it disguised this fact.
The music of the first generation British free improvisers is reliant upon precise
conceptual and practical execution. But though this has enabled the genre to be
musically innovative, in the long term it has also become a logical problem. With
British free improvisation as its subject, the scrutiny of Deconstruction reveals
significant discrepancies between what `free improvisation' implies and what it
actually represents
Photoreaction of functionalized poly(β-benzyl-L-aspartate) with tetrazole and maleimide group
No full textPrva organska sinteza je bila izvedena leta 1828 s sintezo sečnine, prvi sintetični polimer pa je bil sintetiziran leta 1907 – le-ta je bil bakelit. Za svoje diplomsko delo sem iz α-aminokisline β-benzil-L-asparat (BLA) s trifosgenom pripravila monomer β-benzil-L-asparat N-karboksianhidrid (BLA NCA). Trifosgen je pri reakciji dobro aktivacijsko in karbamoilacijsko sredstvo. Reakcijo izvajamo pod brezvodnimi pogoji, ker je N-karboksianhidrid (NCA) zelo občutljiv na vodo, stik z vodo namreč povzroča hidrolizo NCA, nezaželjene stranske reakcije in vodi v njegovo nereaktivnost. Sintetiziran monomer β-benzil-L-asparat N-karboksianhidrid nato polimeriziramo v poli(β-benzil-L-aspartat) (PBLA). Reakcija poteka pri temperaturi ledišča vode. Kot iniciator anionske polimerizacije smo uporabili heksilamin, ki nukleofilno napade β-benzil-L-asparat N-karboksianhidrid in tako povzroči začetek polimerizacije. Poleg tega lahko s spreminjanjem množinskega razmerja med iniciatorjem in monomerom določamo dolžino verige polimera. Sintetiziran polimer nato funkcionaliziramo s dvema fotoodzivnima končnima skupinama. Za svojo diplomsko sem izbrala maleimidno in tetrazolno končno skupino. Pri funkcionalizacji poli(β-benzil-L-aspartat) z maleimidno skupino v suspenzijo polimera v brezvodnem dimetilformamidu dodamo trietilamin in N-sukcinimidil 3-maleimidopropionata, ki reagira s prostimi aminskimi skupinami na poli(β-benzil-L-aspartat) in vsebuje reaktivno maleimidno skupino. Trietilamin deluje kot bazični katalizator, nevtralizira HCl in druge kisle stranske produkte, aktivira karboksilne skupine in prepričuje nezaželene stranske reakcije. Funkcionalizacijo poli(β-benzil-L-aspartata) s tetrazolno skupino izvajamo pod enakimi pogoji, vendar uporabimo druge reaktante: 4-(2-(4-metoksifenil)-2H-tetrazol-5-il)benzojsko kislino s katero funkcionaliziramo polimer, 1-etil-3-(3-dimetilaminopropil)karbodiimid (EDC) in 4-dimetilaminopiridin (DMAP). EDC uporabimo kot aktivator karboksilne skupine poli(β-benzil-L-aspartata), s katero tvori reaktivni intermediat, ki omogoča vezavo tetrazolne skupine in nadaljnjo amidno vezavo. Ker pa je EDC nestabilen, se pogosto uporablja skupaj z DMAP, ki je katalizator pri acilnih substitucijah. Vse produkte po koncu sinteze izoliramo iz reakcijske zmesi in jih okarakteriziramo z tehnikama MALDI-TOF in NMR. Med PBLA funkcionaliziranim z maleimidno in s tetrazolno skupino izvedemo, fotoreakcijo tetrazol-en cikloadicije preko nitril-imina v devteriranem DMSO med osvetljevanjem z UVA svetlobopotek reakcije spremljamo s TLC lučko. Na koncu posnamemo še NMR in MALDI-TOF spekter. Ugotovimo, da fotoreakcija ni potekla po zastavljenem načrtu.The first organic synthesis was carried out in 1828 with the synthesis of urea, while the first synthetic polymer was produced in 1907 – it was Bakelite. For my thesis, I prepared the monomer β-benzyl-L-aspartate N-carboxyanhydride (BLA NCA) from the α-amino acid β-benzyl-L-aspartate (BLA) using triphosgene. Triphosgene acts as an effective activating and carbamoylating agent in the reaction. The reaction is performed under anhydrous conditions because N-carboxyanhydride (NCA) is highly sensitive to watercontact with water leads to hydrolysis of the NCA, undesirable side reactions, and results in its deactivation. The synthesized monomer, β-benzyl-L-aspartate N-carboxyanhydride, is then polymerized into poly(β-benzyl-L-aspartate) (PBLA). The reaction takes place at the freezing point of water. An initiator for anionic polymerization is also requiredin this case, we used hexylamine, which nucleophilically attacks β-benzyl-L-aspartate N-carboxyanhydride and initiates the polymerization. By adjusting the molar ratio between the initiator and the monomer, the polymer chain length can be controlled. The synthesized polymer is then functionalized with two photoresponsive end groups. For my thesis, I selected a maleimide and a tetrazole end group. To functionalize poly(β-benzyl-L-aspartate) with a maleimide group, we added triethylamine and N-succinimidyl 3-maleimidopropionate to a suspension of the polymer in anhydrous dimethylformamide. These reagents react with free amine groups on the poly(β-benzyl-L-aspartate) and contain a reactive maleimide moiety. Triethylamine is used as a basic catalyst to neutralize HCl and other acidic by-products, activate the carboxyl group, and prevent undesired side reactions. The functionalization of poly(β-benzyl-L-aspartate) with a tetrazole group is carried out under the same conditions, but using different reactants: 4-(2-(4-methoxyphenyl)-2H-tetrazol-5-yl)benzoic acid, which is used to functionalize the polymer, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), and 4-dimethylaminopyridine (DMAP). EDC serves as an activator of the carboxyl group in poly(β-benzyl-L-aspartate), forming a reactive intermediate that allows attachment of the tetrazole group via an amide bond. Because EDC is unstable, it is often used in combination with DMAP, which acts as a catalyst for acyl substitution reactions. After completing the synthesis, all products are isolated from the reaction mixture and characterized using MALDI-TOF and NMR spectroscopy. A photoreaction of PBLA functionalized with maleimide and tetrazole groups is carried out through nitrile imine mediated tetrazole-ene cycloaddition in deuterated DMSO under UVA irradiationthe progress of the reaction is monitored using a TLC lamp. Finally, NMR and MALDI-TOF spectra are recorded. It was found that the photoreaction did not proceed as planned
Recurrent ovarian carcinoma: salvage treatment with platinum in patients responding to first-line platinum-based regimens.
No full textSalvage chemotherapy after platinum failure in advanced ovarian cance
Significance of lymph node sampling in epithelial carcinoma of the ovary.
No full textFrom 1979 to 1984, 127 patients operated on for ovarian cancer underwent pelvic, para-aortic, or pelvic and para-aortic lymph node sampling. Forty-seven patients proved to be stage I(14 IA and 33 IC), 14 were stage II(3 IIA, 8 IIB, and 3 IIC), 58 were stage III (7 IIIA, 13 IIIB, and 38 IIIC), and 8 were stage IV. Positive lymph nodes were found in 4.2\% of patients at stage I, 35.7\% at stage II, 41.3\% at stage III, and 87.5\% at stage IV. With regard to grading, positive lymph nodes were found in 4.4\% of G1, in 21.6\% of G2, and in 49.1\% of G3. A significant increase in survival (P = 0.04) was found for patients classified as stage IIIC only according to lymph node involvement compared to patients in peritoneal stage IIIC with positive lymph nodes (3-year survival: 46\% vs 12\%). A small increase in survival was observed for N- patients compared to N+ patients, at both stage III and IV, even with same residual tumor size, but the difference is not statistically significant. All other things being equal, because the prevalence of lymph node positivity depends closely on the number of lymph nodes removed and examined (OR = 3.9 for >10 lymph nodes removed compared to 1-5 lymph nodes removed), lymph node sampling does not seem to be a reliable method for evaluating the retroperitoneal status. With regard to the therapeutic role of systematic lymphadenectomy, few data in literature are available and, most important, are not derived from experimental studies. Probably, only randomized studies with a large number of patients will provide useful answers
Tales of Doukhobor History:
No full textTranslated from his Rasskaz'i iz Istorii Dukhobortsev in the 'Iskra' Publication, Grand Forks, 1966.
Student paper submitted for Anthropology 203
Nove sorte višnje (Prunus cerasus L.) stvorene u Institutu za voćarstvo u Čačku
No full textThe paper presents results of the two-year (2014-2015) study of flowering and ripening time, morphometric properties and biochemical composition of fruits, and field resistance to economically important diseases and pests of newly-recognized sour cherry cultivars ‘Iskra’ (Köröser Weichsel × Heimanns Rubin), ‘Nevena’ (Köröser Weichsel × Heimanns Konserven Weichsel) and ‘Sofija’ (Čačanski Rubin × Heimanns Konserven Weichsel). The new cultivars have large and high quality fruits, with light red (‘Iskra’), dark red (‘Nevena’) and red (‘Sofija’) skin colour. The ripening time was in the second decade (‘Sofija’), i.e. in the third decade of June (‘Nevena’ and ‘Iskra’). The cultivars exhibited a high level of field resistance to Blumeriella jaapii (Rehm.) v. Arx. and Monilinia laxa /Ader et Ruhl./ Honey ex Whetz. Due to the numerous positive bio-economic characteristics, the newly recognized sour cherry cultivars developed at the Fruit Research Institute, Čačak, deserve to be given a place in commercial orchards, as well as in parental combinations of sour cherry breeding programmes.U radu su predstavljeni dvogodišnji rezultati (2014-2015. godina) ispitivanja fenofaza cvetanja i sazrevanja, morfometrijskih osobina i biohemijskog sastava ploda, kao i poljske otpornosti na ekonomski najznačajnije bolesti i štetočine, novopriznatih sorti višnje Iskra (Köröser Weichsel × Heimanns Rubin), Nevena (Köröser Weichsel × Heimanns Konserven Weichsel) i Sofija (Čačanski Rubin × Heimanns Konserven Weichsel). Nove sorte se odlikuju krupnim i kvalitetnim plodovima, svetlocrvene (Iskra), tamnocrvene (Nevena) i crvene boje pokožice (Sofija), koji sazrevaju u drugoj (Sofija), odnosno trećoj dekadi juna (Nevena i Iskra). Ispoljavaju značajan stepen poljske otpornosti na Blumeriella jaapii (Rehm.) v. Arx. i Monilinia laxa /Ader et Ruhl./ Honey ex Whetz. Zbog brojnih pozitivnih biološko-privrednih osobina, novopriznate sorte višnje stvorene u Institutu za voćarstvo u Čačku zaslužuju da se nađu u komercijalnim zasadima, kao i u roditeljskim kombinacijama programa oplemenjivanja višnje
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