1,187 research outputs found
Heckmann über § 137 l UrhG
No full textDer Göttinger Jurist Heckmann hat auf den Konstanzer Open-Access-Tagen über die Nutzungsrechteübertragung gesprochen. http://www.ub.uni-konstanz.de/fileadmin/Dateien/OpenAccess/Heckmann_oa_tage_konstanz07.pdf "Zur Sicherung der Verwertungsmöglichkeiten sollten sich insbesondere Repositorien um eine Nutzungsrechtseinräumung bis zum 1.1.2009 bemühen." Heckmann geht also auch davon aus, dass die Nutzungsrechtseinräumung nicht bis zum 31.12.2007 erfolgen musste. Siehe dazu: ?p=2626
Heckmann über § 137 l UrhG
No full textDer Göttinger Jurist Heckmann hat auf den Konstanzer Open-Access-Tagen über die Nutzungsrechteübertragung gesprochen. http://www.ub.uni-konstanz.de/fileadmin/Dateien/OpenAccess/Heckmann_oa_tage_konstanz07.pdf "Zur Sicherung der Verwertungsmöglichkeiten sollten sich insbesondere Repositorien um eine Nutzungsrechtseinräumung bis zum 1.1.2009 bemühen." Heckmann geht also auch davon aus, dass die Nutzungsrechtseinräumung nicht bis zum 31.12.2007 erfolgen musste. Siehe dazu: ?p=2626
Right of rescission of the author gem. 137 1 Abs. 1 UrhG in practice
No full textAs part of the reform of the German Copyright Act (UrhG) Section 1371 deals with a transitional measure for new types of publication. In particular it allows publishers to make use of online publishing without previous license agreements with copyright holders. However, a copyright holder can prohibit such forms of publication through a formal declaration within one year of the law's enactment. This paper deals with the right to revoke permission and discusses several specific instances in order to show whether, and to what extent, the exercise of this legal right actually safeguards the interests of copyright holders
Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation
No full textAyllon Clemente I, Heckmann M, Denecke A, Wrede B, Görick C. Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation. In: Proceedings INTERSPEECH. 2010
Widely applicable background depletion step enables transaminase evolution through solid-phase screening
No full textDirected evolution of transaminases is a widespread technique in the development of highly sought-after biocatalysts for industrial applications. This process, however, is challenged by the limited availability of effective high-throughput protocols to evaluate mutant libraries. Here we report a rapid, reliable, and widely applicable background depletion method for solid-phase screening of transaminase variants, which was successfully applied to a transaminase from Halomonas elongata (HEWT), evolved through rounds of random mutagenesis towards a series of diverse prochiral ketones. This approach enabled the identification of transaminase variants in viable cells with significantly improved activity towards parasubstituted acetophenones (up to 60-fold), as well as tetrahydrothiophen-3-one and related substrates. Rationalisation of the mutants was assisted by determination of the high-resolution wild-type HEWT crystal structure presented herein
Kritisches Denken im Mathematikunterricht – Ein erster Vorschlag für zentrale Kompetenzen
No full textHeckmann J. Kritisches Denken im Mathematikunterricht – Ein erster Vorschlag für zentrale Kompetenzen. In: Schick L, Platz M, Lambert A, eds. Beiträge zum Mathematikunterricht 2025 . WTM; 2025: 782-785
On the Relationship between Filter Spaces and Equilogical Spaces
No full textIt was already known that the category of T 0 topological spaces is not itself cartesian closed, but can be embedded into the cartesian closed categories FIL of filter spaces and EQU of equilogical spaces where the latter embeds into the cartesian closed category ASSM of assemblies over algebraic lattices. Here, we first clarify the notion of filter space---there are at least three versions FIL a ' FIL b ' FIL c in the literature. We establish adjunctions between FIL a and ASSM and between FIL c and ASSM, and show that FIL b and FIL c are equivalent to reflective full subcategories of ASSM. The corresponding categories FIL b 0 and FIL c 0 of T 0 spaces are equivalent to full subcategories of EQU. Keywords: Categorical models and logics, domain theory and applications Author's address: Reinhold Heckmann, FB 14 -- Informatik, Universitat des Saarlandes, Postfach 151150, D-66041 Saarbrucken, Germany Phone: +49 681 302 2454 Fax: +49 681 302 3065 e-mail: [email protected]..
Release of soybean isoflavones using a β-Glucosidase from Alicyclobacillus herbarius
No full textβ -Glucosidases are used in the food industry to hydrolyse glycosidic bonds in complex sugars, with enzymes sourced from extremophiles better able to tolerate the process conditions. In this work, a novel β-glycosidase from the acidophilic organism Alicyclobacillus herbarius was cloned and heterologously expressed in E. coli BL21 (DE3). Ahe GH1 was stable over a broad range of pH values (5-11) and temperatures (4 oC-55 oC). The enzyme exhibited excellent tolerance to fructose and good tolerance to glucose, retaining 65% activity in the presence of 10% ( w/v ) glucose. It also tolerated organic solvents, some of which appeared to have a stimulating effect, in particular ethanol with a 1.7-fold increase in activity at 10% ( v/v ). The enzyme was then applied for the cleavage of isoflavone from isoflavone glucosides in an ethanolic extract of soy flour, to produce soy isoflavones which constitute a valuable food supplement, achieving full conversion within 15 min at 30 °C
Producing natural vanilla extract from green vanilla beans using a β-glucosidase from Alicyclobacillus acidiphilus
No full textCurrent methods for the production of natural vanilla extract are long and tedious, and the efficiency of the vanillin extraction is usually conditioned by different factors during the traditional curing process (temperatures and weather conditions). As an important fraction of vanillin is present in the form of glucovanillin in green beans, endogenous β-glucosidases contribute to its hydrolysis; however, these enzymes lose efficiency during the curing process. The use of extremophilic organisms as a source of an appropriate exogenous enzyme can offer a valid alternative when producing natural vanillin. Here, a β-glucosidase from the thermo-acidophilic organism Alicyclobacillus acidiphilus (AacGH1) was cloned, expressed in E. coli BL21, and fully characterized in respect to both function and crystal structure. Notably, AacGH1 was stable at a temperature up to 50 °C and exhibited good tolerance to glucose, fructose and organic solvents, in particular it maintained full activity in the presence of up to 20 % (v/v) ethanol. The enzyme was then successfully applied to an ethanol-water (20 % (v/v)) extract of green vanilla beans and the complete hydrolysis of glucovanillin (1.7 mM) to vanillin, and other flavour compounds commonly found in vanilla, was achieved using 0.5 mg/mL of enzyme in just 15 min at 30 °C
Asessing mathematical critical thinking skills - an essay-test using the example of the meat ban in schools
No full textHeckmann J, Runde J, Salle A. Asessing mathematical critical thinking skills - an essay-test using the example of the meat ban in schools. In: Ayalon M, Koichu B, Leikin R, Rubel L, Tabach M, eds. Proceedings of the 46th Conference of the International Group for the Psychology of Mathematics Education. Vol 1. Haifa, Israel: PME; 2023: 255
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