1,721,041 research outputs found
Gli acufeni : eziopatogenesi, diagnosi, approccio terapeutico
No full textL'acufene viene analizzato sotto gli aspetti eziopatogenetici, diagnostici, studiando le differenti proposte terapeutiche.In particolare il modello neurofisologico elaborato da Jastreboff su cui si basano i principi della TRT
Saccule and tinnitus : is a possible connection?
No full textThe saccule is the most mysterious organ of the labyrinth and, for this reason, one of the most fascinating. The aim of this presentation is to explain why the saccule should be taken into consideration for certain forms of tinnitus.
For anatomic, embryologic and physiologic reasons the saccule has both auditory and vestibular characteristics, being the connecting link between the vibratory energy and the vestibular response: it is a bridge between the anterior and the posterior labyrinth; the saccule has a common embryologic origin with the cochlea in the pars inferior of the labyrinth; it is also considered to be the main hearing organ in fishes and other ancestral vertebrates.
The saccule is an otolith organ involved in vertical linear movement detection and sensing gravitational changes; it controls the tonic components of the antigravity muscles contributing to the postural control. In addition, through the vestibule-sympathetic reflexes it contributes to the control of blood pressure during movement and through postural changes.
The anatomical proximity of the saccule to the stapes suggests that an excessive pressure on the footplate may damage the saccular neuroepithelium which lies close to the oval window. Actually, chronic noise exposure has been associated with saccular dysfunction; a possible role of a tonic tensor tympani contraction is discussed. Gussen (1980) reported that a suffering saccular macula dislodges otolith debris that could reach the cochlea through the ductus reuniens and cochlear duct, thus also affecting the cochlear base and the high frequency hearing thresholds.
While the effects of detached utricular otoconia are generally accepted as the cause of Benign Paroxysmal Positional Vertigo, what then happens to the saccular otoconia is not well known yet. An intermittent tinnitus has been described in patients with by BPPV, in the same ear affected by the lithiasis (Barozzi et al. 2014). A new theory of Ménière’s disease based on detached saccular otoconia has been recently proposed (Hornibrook and Bird, 2017).
Based on these considerations, a cooperation between specialists of various disciplines would be beneficial to fully characterize the role of the vestibular organ on tinnitus
Acufeni : cause, diagnosi, terapie : quando un fastidioso fischio agli orecchi non ti abbandona
No full textAffrontare da terapeuta il problema acufene è cosa non semplice ma forse ancor più difficile è scrivere un libro diretto al pubblico non tecnico, un libro che dell’acufene tratti gli aspetti salienti come teoria, diagnosi, terapie.
Questo libro è alla sua seconda edizione aggiornata alle ultime novità diagnostiche e terapeutiche. E' destinato a chi soffre di acufene, per offrire un aiuto immediato oltre che una speranza di guarigione.
L’acufene è un disturbo multifattoriale, cioè generato e mantenuto da diverse cause che, oltretutto, variano da persona a persona. Per questo motivo va trattato da terapisti con una salda e aggiornata formazione specialistica, ma contemporaneamente aperti a tutte le discipline mediche e terapeutiche.
Questo libro è stato scritto da specialisti affermati di ciascun settore che, ogni giorno, incontrano e “curano” persone con acufene oltre a fare ricerca. Il lettore potrà notare piccole differenze di stile e di approccio tra un capitolo e l’altro; inoltre, alcuni argomenti necessariamente si ripetono. Non credo che ciò sia un difetto, anzi sono sicuro che le ripetizioni siano utili per comprendere meglio un tema complesso come l’acufene.
Vorrei aggiungere alcune avvertenze importanti per il lettore:
• il libro presenta: le cause di acufene introducendo contemporaneamente elementi di anatomia e fisiologia, partendo dall’orecchio per arrivare al cervello; gli approcci terapeutici e le teorie più aggiornate sul problema;
• è bene non bloccarsi se qualche cosa non sembra immediatamente comprensibile, proseguendo è probabile ritrovare il medesimo concetto ripetuto con parole diverse nei capitoli successivi da autori differenti;
• alcuni argomenti, come il funzionamento del cervello sono complessi anche per gli addetti ai lavori. Quindi è bene non scoraggiarsi se, a prima vista, risultano di difficle comprensione!
• aspetti, come la diagnosi audiologica, sono stati approfonditi per fornire alla persona con acufeni gli elementi per capire gli esami ai quali, inevitabilmente, va incontro. E capire è un po’ guarire....
• questo libro non sostituisce il medico! Diagnosi e terapia devono essere effettuate da personale qualificato e preparato sull’argomento. Il fai da te può essere molto pericoloso
A possible role of inner ear melanocytes in tinnitus and audiovestibular disorders
Full text linkMelanocytes are present in the skin and hair follicles, as well as in the eye, the leptomeninges, the anal canal and the inner ear. In the inner ear melanocytes are found both in the intermediate layer of the stria vascularis of the cochlea and in the dark cells of the vestibular organs. They are believed to play an important role in the production of endolymphatic potentials and in the maintenance of normal volumes of the inner ear fluids. Melanocytes disorders have been associated to some audiological abnormalities such as the Waardenburg syndrome and/or the Vogt-Kayanagi-Harada
syndrome, characterized by both hearing impairment and pigmentation abnormalities. We propose that melanocytes could potentially be involved with inner ear fluid pressure dysfunction influencing conditions such as endolymphatic hydrops and Ménière’s disease. Recently, we reported the case of a patient in whom the appearance of a choroidal melanoma coincided with the exacerbation of tinnitus and vertigo spells in a unilateral Ménière’s disease that had been clinically silent for more than ten years. The symptoms disappeared after the radiotherapy treatment and did not show up again during the following three years. We suggest that inner ear melanocytes could be a target of an autoimmune process in patients affected by melanoma as well retinal melanocytes in melanoma-associated retinopathy. The immune system could produce antibodies that cross-react with both the melanoma cells and the labyrinth melanocytes, causing an altered homeostasis of endolymphatic liquids. In this perspective, audiovestibular disorders could be interpreted as an attempt by the individual immune system to develop anti-tumoral response. Autoimmune processes affecting inner ear melanocytes could be considered as a potential cause of tinnitus and audiovestibular disorders
Valutazione dei risultati dei diversi trattamenti per la terapia dell'acufene
No full textIn base all'anlisi della letteratura vengono valutati i risultati relativi alle differenti terapie proposte per l'acufene: sound terapy,tinnitus retaaining therapy, neuromonics, trattamenti farmacologici, stimolazione magnetica e laser, trattamenti chirurgici,terapie complementari,farmaci naturali e vitamine
Identificazione di geni maggiori d’interesse economico (ETL) per la resistenza alle malattie
No full textDespite eradication programs, bovine tuberculosis is still a sanitary and economic problem in Italy. Genetic effect on immune response to M.bovis plays a central role to determine resistance or susceptibility to disease. The two genes so far identified as involved in immunity to TB are Major Histocompatibility Complex (MHC) and natural resistance associated macrophage protein 1 (NRAMP1). MHC polymorphism modulates antigen presentation and immune paths activation; NRAMP1 determines the ability of macrophages to control M. bovis infection. It has been demonstrated that NRAMP1 even influences the level of MHC class II expression. In this study we have analysed the polymorphisms and sequences of the MHC antigen-binding grove in calves immunised to M.bovis in relation to specific immune response. Moreover bovine NRAMP1 gene has been sequenced and analysed by SSCP technique and microsatellite analysis.
Parole chiave: Tubercolosi, Bovino, MHC, NRAMP1
The effect of a gluten-free diet on a patient complaining of severe tinnitus
No full textWe report a case of a patient complaining of severe high pitched tinnitus, dizziness, joint/muscle pain and gastrointestinal symptoms. A mild high-frequency sensorineural hearing loss of cochlear origin was diagnosed in the ear where tinnitus was present. The patient reported a considerable decrease in tinnitus and other symptoms with a gluten-free diet. Gluten sensitivity may have contributed to the pathogenesis of tinnitus in our patient; further research is needed to determine the exact role of gluten in this condition
Caratterizzazione genetica della pecora sarda con microsatelliti. Atti IV Congresso nazionale Biodiversità : Germoplasma animale e sua valorizzazione
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