233 research outputs found
Do we still need CD4 T cell count?
No full textThe relevance of CD4 T cell count as pivotal marker of HIV disease progression and response to HAART is well established. The authors explore the potential role of immunological markers other than CD4 count in the management of HIV-infected individuals, and consider their usefulness and convenience in clinical practice
GAMBARAN HISTOPATOLOGI INSANG, HEPATOPANKREAS DAN GINJAL IKAN BUTINI (Glossogobius matanensis, Weber) DI DANAU MATANO LUWU TIMUR SULAWESI SELATAN YANG TERCEMAR LOGAM BERAT NIKEL (Ni) DAN BESI (Fe)
No full text2015NURUL SULFI ANDINI. Gambaran Histopatologi Insang, Hepatopankreas, dan Ginjal Ikan Butini (Glossogobius matanensis, Weber) di Danau Matano Luwu Timur Sulawesi Selatan yang Tercemar Logam Berat Nikel (Ni) Dan Besi (Fe). Di bawah bimbingan DWI KESUMA SARI dan HILAL ANSHARY\ud
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Ikan butini (Glossogobius matanensis) merupakan salah satu jenis ikan perairan tawar yang hidup dan bersifat endemik di Danau Matano. Tujuan dari penelitian ini untuk mengetahui gambaran histopatologi insang, hepatopankreas dan ginjal dari ikan butini. Sampel yang digunakan sebanyak 6 ekor ikan Butini dengan ukuran kurang lebih 18,5 - 20,5 cm. Preparat organ (insang,hepatopancreas,dan ginjal) difiksasi menggunakan neutral buffered formalin (NBF) 10%, dehidrasi menggunakan alcohol bertingkat, embedding dengan menggunakan paraffin, pemotongan dengan ketebalan 5 ??m yang diwarnai dengan menggunakan HE (Haematoksilin Eosin) kemudian diberi canada balsam lalu covering. Selain pembuatan preparat histopatologi organ juga dilakukan pengukuran terhadap kadar logam yang terkandung dalam perairan Danau Matano. Analisis data yang digunakan adalah dekriptif kualitatif. Berdasarkan hasil pengamatan diperoleh kerusakan atau histopatologi yang terjadi pada organ insang yaitu berupa hipertropi, hemoragi, edema, fusi lamella, dan penebalan lamella primer. Pada hepatopankreas terdapat degenerasi lemak, degenerasi hidrofik, sel nekrosis. Dan pada ginjal berupa lisis tubulus ginjal, membran basalis terlepas, dan sel ???sel nekrosis. Dari hasil pengukuran kadar logam di danau tersebut mengandung nikel sebanyak <0.0184 mg/L, besi sebanyak 0.0238 mg/L, seng sebanyak 0.0491 mg/L dan tembaga sebanyak <0,0136 mg/L yang rata-rata menghampiri batas maksimum. Oleh karena itu, tingginya konsentrasi logam diduga memiliki hubungan dengan abnormalitas jaringan organ ikan yang diobeservasi dalam penelitian ini. \ud
Kata kunci : butini, insang, hepatopankreas, ginjal, histopatolog
Changes in CD8 cell subpopulations induced by antiretroviral therapy in human immunodeficiency virus infected patients.
No full textGenotypic Resistance Tests for the Management of Structured Therapeutic Interruptions after Multiple Drug Failure: Prosecution
No full textThe FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity
No full textSynthetic cannabinoids and phytocannabinoids have been shown to suppress seizures both in humans and experimental models of epilepsy. However, they generally have a detrimental effect on memory and memory-related processes. Here we compared the effect of the inhibition of the endocannabinoid (eCB) degradation versus synthetic CB agonist on limbic seizures induced by maximal dentate activation (MDA) acute kindling. Moreover, we investigated the dentate gyrus (DG) granule cell reactivity and synaptic plasticity in naïve and in MDA-kindled anaesthetised rats. We found that both the fatty acid amide hydrolase (FAAH) inhibitor URB597 and the synthetic cannabinoid agonist WIN55,212-2 displayed AM251-sensitive anti-seizure effects. WIN55,212-2, dose-dependently (0.5-2 mg/kg, i.p.) impaired short-term plasticity (STP) and long-term potentiation (LTP) at perforant path-DG synapses in naïve rats. Strikingly, URB597 (1 mg/kg, i.p.) was devoid of any deleterious effects in normal conditions, while it prevented seizure-induced alterations of both STP and LTP. Our evidence indicates that boosting the eCB tone rather than general CB1 activation might represent a potential strategy for the development of a new class of drugs for treatment of both seizures and comorbid memory impairments associated with epilepsy. © 2017 The Author(s)
Cervical dysplasia in HIV-seropositive women: role of human papillomavirus infection and immune status
No full textIn the present study we investigated the cytologic and colposcopic characteristics of a cohort of HIV-infected women, with the aim to determine a relationship between immunologic status and frequency and/or severity of cervical abnormalities
CD8+ T Iymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity
No full textHIV-induced abnormalities in myelopoiesis and their recovery following antiretroviral therapy
No full textThymopentin in a case of autoimmune thrombocytopenia secondary to chronic lymphatic leukemia [Timopentina in un caso di piastrinopenia autoimmune secondaria a leucemia linfatica cronica]
No full textThe Authors describe a case of chronic lymphocytic leukemia complicated by immune thrombocytopenic purpura. They consider the various causes of thrombocytopenia during lympho-proliferative disorders and underline the different prognostic significance. They evaluate the efficacy of treatment with timopentina
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