1,720,976 research outputs found
Improvement in Industrial Re-chromatography (Recycling) Procedure in Solvent Gradient Bio-Separation Processes
No full textParametric Study of a 6-column Countercurrent Solvent Gradient Purification (MCSGP) Unit
No full text"Role of Cleaning-in-Place in the Purification of mAb Supernatants Using Continuous Cation Exchange Chromatography"
No full textModeling of the chromatographic solvent gradient reversed phase purification of a multicomponent polypeptide mixture
No full textA model for Calcitonin purification from an industrial peptide mixture using polymer-based reversed phase columns was developed. Regressed competitive bi-Langmuir isotherm parameters for pure calcitonin are strong functions of the eluent composition and were correlated to the overall Henry coefficient only. It is shown that, by keeping constant these correlations, the adsorption behavior of impurities can be predicted simply by estimating their Henry coefficient from the raw mixture. The same can be repeated with very good results when changing the stationary phase or the organic solvent in the eluent. In both cases, only the Henry coefficient must be re-estimated from pulse injections
A continuous, counter-current multi-column chromatographic process incorporating modifier gradients for ternary separations
No full textImprovement of an overloaded, multi-component, solvent gradient bioseparation through multiobjective optimization
No full text"Improvement of specific monoclonal antibody (mAb) activity by reduction of the mAb heterogeneity using continuous chromatography (MCSGP)"
No full textRole of re cycling in improving the performance of chromatographic solvent gradient purifications
No full text"The role of ion-pairing in peak deformations in overloaded reversed-phase chromatography of peptides"
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