1,721,155 research outputs found
One Step Beyond. Outcomes of Doctoral Research in Design, Year 2017
No full textThis essay provides a general overview of the topics, contents and research methodologies adopted in the PhD program in Design at Politecnico di Milano, since its inception in 2009. In this framework the 9 PhD theses published in the book are described and commented
Identification of DeltaNp63 alpha protein interactions by mass spectrometry.
No full textp63, a transcription factor related to the p53 tumor suppressor, plays a key role in epidermal differentiation and limb development. The gene has two distinct promoters that allow the formation of proteins that either contain (TA) or lack (DeltaN) a transactivation domain. DeltaNp63alpha is the most widely expressed isoform, at all stages of development and in adult tissues. It supports the regenerative capacity of basal keratinocytes and its upregulation is a hallmark of human squamous carcinomas. To get insight into the complex biology of DeltaNp63alpha, we set out to identify DeltaNp63alpha interacting proteins by co-immunoprecipitation in mammalian cells and mass spectrometry analysis. A total of 49 potential DeltaNp63alpha binding proteins, including several heterogeneous ribonucleoproteins (hnRNPs), were identified. Integration of the proteomic data with a Human Coexpression Network highlighted 5 putative p63 protein interactors whose expression is significantly comodulated with p63: hnRNPA/B, hnRNPK, hnRNPQ, FUS/TLS and Keratin 5. hnRNPA/B was already described as a p63 partner, but the others were novel. Interaction of DeltaNp63alpha with hnRNPQ, hnRNPK and FUS/TLS was confirmed by reciprocal co-immunoprecipitations in human keratinocytes. The finding that DeltaNp63alpha exists in complexes with several RNA-binding proteins lays the premises for the analysis of the role of DeltaNp63alpha in mRNA metabolism and transport
Il Palazzo del Quirinale. Studi preliminari
No full textIl volume include una serie di saggi preparatori alla stesura del catalogo sistematico della raccolta di sculture antiche conservata nel Palazzo del Quirinale
Transitional dynamics in the Solow-Swan model with AK technology and logistic population change
No full textThis paper offers an alternative way, based on the logistic population growth hypothesis, to yield transitional dynamics in the standard AK model with exogenous savings rate. Within this framework, we show that the dynamics of the capital stock per person and its growth rate can be non-monotonic over time. Moreover, even in the presence of negative growth, the capital stock per-capita can converge to a strictly positive level (different from the initial level) when time goes to infinity. In general, the analysis allows us to conclude that the dynamics of the Solow-Swan model with linear technology and logistic population growth is richer than the one with exponential population growt
54esima Biennale di Venezia - Padiglione della Repubblica di San Marino
No full textTitolo del progetto: "Luce In-azione"
Artisti: Dorothee Albrecht, Marco Bravura, Cristian Ceccaroni, Daniela Comani, Ottavio Fabbri, Verdiano Manzi, Patrizia Merendi, Omar Paolucci, Cristina Rotondaro, Lars Teichmann, Thea Tini, Daniela Tonelli, Paola Turroni
Commissario: Leo Marino Morganti.
Curatore: Valerio Pradal
Comitato scientifico e di selezione delle opere:
A. Bassi
F. Cavallari
M. Comoglio
L. Guerrini
M. G. Riva
R. Stih
C. Tartarin
"Design on the thread of tradition" in L. Guerrini in "Educating for research. The new PhD degree programme in Design at the Politecnico di Milano".
No full textContributo sulle tematiche di ricerca inerenti il programma PhD al Politecnico di Milano inserito all'interno del paper di L. Guerrini in "Educating for research. The new PhD degree programme in Design at the Politecnico di Milano"
On the correlation between the modulus of elasticity and the compressive strength in VHSC
No full textVENEZI
Meritevolezza e arricchimenti (in)giustificati: il "contratto di rivelazione di diritti successori".
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