448 research outputs found
Anti-Discrimination Law in Civil Law Jurisdictions
No full textFoubert, P (corresponding author), Hasselt Univ, Hasselt, Belgium
Anti-Discrimination Law in Civil Law Jurisdictions
No full textFoubert, P (corresponding author), Hasselt Univ, Hasselt, Belgium
UvA-DARE (Digital Academic Repository) HUMU 780 A Single Ser259Arg Mutation in the Gene for Lipoprotein Lipase Causes Chylomicronemia in Moroccans of Berber Ancestry
No full textA single Ser 259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry Foubert, L.; Bruin, T.; de Gennes, J.L.; Ehrenborg, E.; Furioli, J.; Kastelein, J.J.P.; Benlian, P.; Hayden, M.R. Published in: Human Mutation Link to publication Citation for published version (APA): Foubert, L., Bruin, T., de Gennes, J. L., Ehrenborg, E., Furioli, J., Kastelein, J. J. P., ... Hayden, M. R. (1997). A single Ser 259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry. Human Mutation, 10, 179-185. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible
Qualitative employment relationships for Ph.D. students in the EU?
No full textThis contribution intends to shed light on the working conditions of Belgian and Italian Ph.D.The author(s) received no financial support for the research, authorship, and/or publication of this article
Resuspended freeze-dried Nannochloropsis as a model laboratory system for concentrated fresh Nannochloropsis in ultrasound cell disruption experiments
No full textMicroalgae have rigid, complex cell walls hindering direct lipid extraction. Cell disruption techniques are used to rupture these cellular structures to increase lipid extraction. Researchers investigating the downstream processing of microalgae do not always have access to microalgal cultivation systems to generate large amounts of fresh microalgal biomass. Using resuspended freeze-dried microalgal biomass as a model laboratory system for concentrated fresh biomass during cell disruption experiments offers greater flexibility in experimental planning and omits investment costs of microalgal cultivation equipment. So far, it however remains unclear whether freeze-dried resuspended biomass can be used as a model laboratory system to represent concentrated fresh biomass during cell disruption and lipid extraction experiments. This paper thus evaluated the suitability of resuspended freeze-dried Nannochloropsis as a model laboratory system for concentrated fresh Nannochloropsis during cell disruption. Ultrasound assisted cell disruption was used as example cell disruption technique and lipid extraction efficiency and free fatty acid content were investigated. Tap water and 3% sodium chloride are both suitable resuspension media for the resuspension of freeze-dried Nannochloropsis. Resuspension duration should be limited (< 120 min) to prevent the formation of free fatty acids. The condition of the biomass (concentrated fresh, or resuspended freeze-dried) prior to ultrasound assisted cell disruption did not influence the resulting lipid extraction efficiency. Resuspended freeze-dried Nannochloropsis biomass in tap water or 3% sodium chloride can thus be used as a model laboratory system for fresh microalgal biomass during research on ultrasound assisted lipid extraction. The generalization of the results to other cultivation conditions, cell disruption techniques, components of interest or microalgal species should be carefully assessed.The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by Flanders’ Food and funded by Flanders Innovation and Entrepreneurship (VLAIO) through the cSBR
project EffSep (Grant number HBC.2019.0012)
Intrusions in story recall: When over-learned information interferes with episodic memory recall. Evidence from Alzheimer’s disease.
No full textPatients with Alzheimer’s disease (AD) suffer from distortions of memory. Among such distortions, intrusions in memory tests are frequently observed.
In this study we describe the performance of a group of mild AD patients and a group of normal controls on the recall of three different types of stories: a previously unknown story, a well-known fairy-tale (Cinderella), and a modified well-known fairy-tale (Little Red Riding Hood is not eaten by the wolf).
The aim of our study was to test the hypothesis that in patients who tend to produce intrusions, over-learned information interferes with episodic recall, i.e., the retrieval of specific, unique past episodes. AD patients produced significantly more intrusions in the recall of the modified fairy-tale compared to the recall of the two other stories. Intrusions in the recall of the modified fairy-tale always consisted of elements of the original version of the story. We suggest that in AD patients intrusions may be traced back to the interfer- ence of strongly represented, over-learned information in episodic memory recall
In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites of Filipendula ulmaria
No full text(1) Background: Filipendula ulmaria (L.) Maxim. (Rosaceae) (meadowsweet) is widely used in phytotherapy against inflammatory diseases. However, its active constituents are not exactly known. Moreover, it contains many constituents, such as flavonoid glycosides, which are not absorbed, but metabolized in the colon by gut microbiota, producing potentially active metabolites that can be absorbed. The aim of this study was to characterize the active constituents or metabolites. (2) Methods: A F. ulmaria extract was processed in an in vitro gastrointestinal biotransformation model, and the metabolites were characterized using UHPLC-ESI-QTOF-MS analysis. In vitro anti-inflammatory activity was evaluated by testing the inhibition of NF-κB activation, COX-1 and COX-2 enzyme inhibition. (3) Results: The simulation of gastrointestinal biotransformation showed a decrease in the relative abundance of glycosylated flavonoids such as rutin, spiraeoside and isoquercitrin in the colon compartment, and an increase in aglycons such as quercetin, apigenin, naringenin and kaempferol. The genuine as well as the metabolized extract showed a better inhibition of the COX-1 enzyme as compared to COX-2. A mix of aglycons present after biotransformation showed a significant inhibition of COX-1. (4) Conclusions: The anti-inflammatory activity of F. ulmaria may be explained by an additive or synergistic effect of genuine constituents and metabolites
Anti-inflammatory effect of Adelia ricinella L. aerial parts
No full textObjective
To investigate the main chemical components and the anti-inflammatory activity of extracts of Adelia ricinella L. aerial parts.
Methods
Three extracts obtained by soxhlet extraction and ethanol/water mixtures were evaluated in their chemical composition by UPLC-DAD-MS/MS. The in vitro anti-inflammatory activity of the prepared extracts was assessed through three different assays: COX-1 and COX-2 enzymatic inhibition, cell-based COX assays on RAW264.7 macrophages (ATCC) measuring the COX-2 protein expression by Western blot and the measurement of the PGE2 concentration in the supernatants of the culture medium. Also was determinate the effect of the three extracts on the RAW 264.7 cell viability.
Key findings
Few differences in the phytochemical profile were found between the three prepared extracts, identifying a blend of thirteen flavonoids derived from luteolin and apigenin, with orientin as main constituent. Plant extracts (alcoholic and aqueous) did not affect the macrophage cell viability (IC50 > 256 μg/ml) and significantly reduced COX-1 and COX-2 enzyme activities. Additionally, COX-2 expression and PGE2 release were suppressed after 24 h of LPS stimulation and treatment with plant extracts (8–64 μg/ml).
Conclusions
A. ricinella extracts showed the ability to reduce the inflammatory effect exerted by LPS in murine macrophages. However, further studies should confirm their anti-inflammatory activity
Oxidatieve stabiliteit van omega-3 langketen poly-onverzadigde vetzuren in groentepurees aangerijkt met microalgen
No full textFruit and vegetables are important carriers of bio-active components whereof the daily intake by the major part of the population is often too low. The largest part of fruit and vegetables is consumed as low fat dispersed food like juices, sauces and soups. Microalgae on theirside have been identified as a source of omega-3 long chain poly-unsaturated fatty acid. The objective of this Ph.D. is to combine the potential of both products by enriching fruit and vegetable based products with microalgae. The potential of different microalgae will be screened. The microalgae will be suspended as biomass as well as oil in a buffered aqueous solution and will be thermally and HPH treated. The homogenous suspensions will be chemically analyzed with different technics on total lipid content, lipid profile, phenolic, tocopherol and ascorbic acid content, carotenoid content, … Based on those results a selection of a few microalgae will be made for further experiments. Afterwards the impact of processing and storage will be examined on the lipid stability of the selected microalgae adjusted in real fruit- and vegetable matrices. Also the flavor of the matrices will be examined. Those researches will bring more insight in the stability of lipids of microalgae in fruit and vegetable matrices and in the potential to combine both components to boost the nutritional value.status: Publishe
Replication Data for: Stabilization of Vitamin A by Cereal Bran: The Importance of the Balance between Antioxidants, Pro-oxidants, and Oxidation-Sensitive Components
No full textThis data set contain all data related to the publication: Van Wayenbergh, E., Coddens, L., Langenaeken, N. A., Foubert, I., & Courtin, C. M. (2023). Stabilization of Vitamin A by Cereal Bran: The Importance of the Balance between Antioxidants, Pro-oxidants, and Oxidation-Sensitive Components. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71(41), 15296-15304. doi:10.1021/acs.jafc.3c04585.
Two accelerated storage experiments were performed with samples consisting of heat-treated wheat or rice bran mixed with vitamin A-enriched oil. In the first storage experiment, certain bran fractions were sequentially removed. In the second storage experiment, certain bran fractions were re-added to obtain reconstituted samples. The removed bran fractions were also analysed for their antioxidant and lipid composition. The aim was to identify which antioxidants and lipids contribute to vitamin A stabilisation by cereal bran during storage
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