2,272 research outputs found
Association Between Preoperative Fibrinogen-to-Albumin Ratio and All-Cause Mortality After Off-Pump Coronary Artery Bypass Grafting: A Retrospective Observational Study
No full textBACKGROUND: The fibrinogen-to-albumin ratio (FAR) is a recently introduced prognostic marker for patients with coronary artery disease. The present study investigated whether the FAR is associated with clinical outcome after off-pump coronary artery bypass grafting (OPCAB). METHODS: We retrospectively reviewed 1759 patients who underwent OPCAB (median duration of follow-up, 46 months). To evaluate the association between FAR and mortality in OPCAB patients, time-dependent coefficient Cox regression analyses were used to assess the association between FAR and all-cause mortality. RESULTS: In multivariable time-dependent coefficient Cox regression analyses, preoperative FAR was an independent risk factor for all-cause mortality after OPCAB (adjusted hazard ratio, 1.051; 95% confidence interval, 1.021-1.082). In the restricted cubic spline function curve of the multivariable-adjusted relationship between the preoperative FARs, a linear increase in the relative hazard for all-cause mortality was observed as the FAR increased (P = .001). CONCLUSIONS: A higher FAR is associated with increased all-cause mortality after OPCAB. The preoperative FAR could be a prognostic factor for predicting higher mortality after OPCAB.N
Supplemental material for Delta neutrophil index as an early predictive marker of severe acute pancreatitis in the emergency department
No full textSupplemental Material for Delta neutrophil index as an early predictive marker of severe acute pancreatitis in the emergency department by Tae Y Kim, Sun J Kim, Yoon S Kim, Jong W Lee, Eung J Park, Seok J Lee, Kyong J Lee and Yong S Cha in United European Gastroenterology Journal</p
저전압 구동 상온 공정 박막트랜지스터를 위한 게이트 절연막으로서 억셉터가 도핑된 박막에 관한 연구
No full text학위논문(박사) - 한국과학기술원 : 신소재공학과, 2007.2, [ xi, 114 p. ]Flexible electronics on polymer substrates require device structures that are amendable to room temperature fabrication and processing. Organic thin film transistors (OTFTs) based on pentacene satisfy this criteria. OTFTs have received intense interest for applications requiring, structural flexibility, large area coverage, and low-cost. Such applications include active matrix OLED/LCD displays, sensing devices, and radio frequency identification (RFID) tags. To obtain low voltage operation (a requirement for low power electronic systems) and high performance (i.e. high mobility), OTFTs often require the use of high capacitance gate insulator suitable for portable, battery-powered device applications. High capacitance gate insulators can be obtained by the use of very thin films and/or high dielectric constant gate materials. Very thin gate insulators can lead to significant manufacturing problems given that the surface roughness of the polymers may be on the order of the thickness of the insulators leading to pinholes in the insulator, and high resultant leakage currents. Flexible polymer substrates, often characterized by rough surfaces (RMS roughness ~ 3 nm), therefore benefit from the use of high-K dielectrics given that high electric fields can be achieved with use of thicker films (~ 200 nm) without need to increase operating voltage. Further, room temperature processing could enable 3D integration of large stacks of active electronic device layers as well as flexible/wearable electronics, and conformable 3D imaging.
In addition, transparent thin film transistors (TTFTs), represented by ZnO-based TFTs which can be processed at room temperature have attracted much attention due to their potential of replacing hydrogenated amorphous or polycrystalline silicon (a-Si:H or poly-Si) TFTs. ZnO is a transparent compound semiconductor with a wide band gap (3.37 eV) which can be grown as a polycrystalline film at room temperature. Therefore, ZnO is considered to...한국과학기술원 : 신소재공학과
Facilitation of circadian rhythm with transcriptional regulation of D site-binding protein by hnRNP K
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The poly(C) motif in the proximal promoter region of the D-box binding protein (DBP) drives its high-amplitude oscillation
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Effects of remote ischemic preconditioning on platelet activation and reactivity in patients undergoing cardiac surgery using cardiopulmonary bypass: a randomized controlled trial
No full textDuring cardiopulmonary bypass (CPB), platelet activation and dysfunction are associated with adverse outcomes. Remote ischemic preconditioning (RIPC) has been shown to attenuate platelet activation. We evaluated the effects of RIPC on platelet activation during CPB in patients undergoing cardiac surgery. Among 58 randomized patients, 26 in the RIPC group and 28 in the sham-RIPC group were analyzed. RIPC consisted of 4 cycles of 5-min ischemia induced by inflation of pneumatic cuff pressure to 200 mmHg, followed by 5-min reperfusion comprising deflation of the cuff on the upper arm. Platelet activation was assessed using flow cytometry analysis of platelet activation markers. The primary endpoint was the AUC of CD62P expression during the first 3 h after initiation of CPB. Secondary outcomes were the AUC of PAC-1 expression and monocyte-platelet aggregates (MPA) during 3 h of CPB. The AUCs of CD62P expression during 3 h after initiation of CPB were 219.4 ± 43.9 and 211.0 ± 41.2 MFI in the RIPC and sham-RIPC groups, respectively (mean difference, 8.42; 95% CI, −14.8 and 31.7 MFI; p =.471). The AUCs of PAC-1 expression and MPA did not differ between groups. RIPC did not alter platelet activation and reactivity during CPB in patients undergoing cardiac surgery
MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer’s Disease
No full textAlzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks of AD. The autophagic lysosomal pathway is the essential mechanism to maintain cellular homeostasis by driving clearance of protein aggregates and is dysfunctional in AD. Here, we showed that inhibiting MEK/ERK signaling using a clinically available MEK1/2 inhibitor, trametinib (GSK1120212, SNR1611), induces the protection of neurons through autophagic lysosomal activation mediated by transcription factor EB (TFEB) in a model of AD. Orally administered trametinib recovered impaired neural structures, cognitive functions, and hippocampal long-term potentiation (LTP) in 5XFAD mice. Trametinib also reduced Aβ deposition via induction of autophagic lysosomal activation. RNA-sequencing analysis revealed upregulation of autophagic lysosomal genes by trametinib administration. In addition, trametinib inhibited TFEB phosphorylation at Ser142 and promoted its nuclear translocation, which in turn induced autophagic lysosomal related genes, indicating that trametinib activates the autophagic lysosomal process through TFEB activation. From these observations, we concluded that MEK inhibition provides neuronal protection from the Aβ burden by increasing autophagic lysosomal activity. Thus, MEK inhibition may be an effective therapeutic strategy for AD
Author Correction: Evaluation of skin cancer resection guide using hyper‑realistic in‑vitro phantom fabricated by 3D printing
No full textThe original version of this Article contained an error in the spelling of the author Taehun Kim which was incorrectly given as Teahun Kim. The original Article has been corrected
Gold nanoparticle-enhanced secondary ion mass spectrometry and its bio-applications
No full textEnhancement of signals in time-of-flight secondary ion mass spectrometry (ToF-SIMS) studies is necessary to many biological applications. We have developed an efficient method of enhancing the signals of secondary ions from peptides using gold nanoparticles (AuNPs) attached to a well-controlled surface such as self-assembled monolayers (SAMs). AuNPs function as both signal enhancers and effective binding sites for peptides, which allow the high signal intensity from the peptides to produce well-contrasted ToF-SIMS images of peptides that are micropatterned on the surface of the AuNPs. For application, this AuNP-enhanced SIMS (NE-SIMS) provided the basis for the spectrum and images to assay protein kinases and their inhibitors. Phosphorylation efficiency and inhibitor effect were quantified by detecting mass change of the peptide substrates by kinase reaction. Maximum efficiency of phosphorylation was achieved from cysteine-tethered peptides with a spacer linker, indicating that accessibility of kinase was dependent on the surface orientation and length of the peptide substrate on the three-dimensional AuNPs. The activities of other enzymes such as phosphatase and protease could also be assayed using NE-SIMS. Our study shows that NE-SIMS can be applied as a useful tool for enzyme assay in biochip surfaces. (C) 2008 Elsevier B. V. All rights reserved
hnRNP Q and PTB modulate the circadian oscillation of mouse Rev-erb alpha via IRES-mediated translation
No full textThe physiological and behavioral circadian rhythms of most creatures are controlled by a harmony of functional relationships between clock genes. In mammals, several core clock genes show rhythmic profiles of their mRNA and protein expression. Among them, Rev-erb alpha functions as a transcriptional repressor, affecting expression patterns of other clock genes. For the continuous and robust oscillation of the molecular clock system, the levels of Rev-erb alpha protein are expected to be tightly regulated with the correct timing. Here, we demonstrate that Rev-erb alpha has an internal ribosomal entry site (IRES) in its 5' untranslated region. Furthermore, we demonstrate that heterogeneous nuclear ribonucleoprotein Q and polypyrimidine tract-binding protein (PTB) modulate the IRES-mediated translation of Rev-erb alpha. We suggest that the rhythmic binding affinity of hnRNP Q to the Rev-erb alpha IRES and the change in PTB cytosolic levels lead to maintenance of the oscillation profile of the Rev-erb alpha protein.X113131sciescopu
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