65 research outputs found
Mosaic Atlas: Interview with Trami Cron
No full textInterview with Trami Nguyen Cron, Executive Artistic Director of Chopsticks Alley Art. She identifies as Vietnamese American. She is an author and directs the hub, Chopsticks Alley Art, promoting Southeast Asian art and culture. Topics discussed inclue the work of the organization, the move to Downtown San Jose, her books, including VietnamEAZY: A Novel about Mothers, Daughters, and Food, the importance of representation in the arts for the Vietnamese communities, Tet, and extension to broader Southeast Asian audiences. As part of the Mosaic Atlas project, SJSU students and faculty from the Anthropology and Geography Departments interviewed people who support and produce art throughout the Bay Area
Circonvolutions
No full textUnderlining its heterogeneous character, Cron outlines the history of Canadian and Quebec video. The author surveys the medium's territories (documentary, fiction, experimentation) and traces the dynamic contours of the trans-Canadian network through 34 videos. 20 bibl. ref
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PKC ? Germline Variants and Genetic Deletion in Mice Augment Anti-Tumor Immunity Through Regulation of Myeloid Cells
No full textAntibodies blocking the PD-1/PD-L1 axis and other immune checkpoints have revolutionized cancer care. Clinical response is favored in tumors showing a T cell-inflamed tumor microenvironment at baseline 1,2, which is tremendously variable between patients and also across tumor types 3. Despite the importance of this immunobiological phenotype, the mechanisms explaining such inter-patient heterogeneity are just beginning to be understood. Based on the notion that hypomorphic germline variants in immunoregulatory genes are linked to autoimmune diseases 4, one hypothesis is that germline variants might favor spontaneous immune priming and T cell infiltration into tumors. To investigate this possibility, we utilized TCGA data and identified germline variants in the PKC gene associated with decreased expression of PRKCD and an increased immune gene signature in the tumor microenvironment. Genetic deletion of PKC in mice resulted in improved endogenous anti-tumor immunity and increased efficacy of PD-1/PD-L1 blockade. Single cell RNAseq of immune cells in the tumor revealed expression of Prkcd in myeloid cells, and PKC deletion caused a macrophage shift from an M2-like to an M1-like phenotype. Conditional deletion of PKC in macrophages recapitulated the improved tumor control phenotype and response to anti-PD-L1 treatment. Analysis of clinical samples from melanoma patients confirmed an association between PRKCD variants and M1/M2 phenotype, and between a PKC KO-like gene signature and clinical benefit from anti-PD-1. Our results suggest that reduced PKC in host cells leads to improved anti-tumor immunity and PD-1 blockade efficacy through a myeloid shift to an M1-like phenotype, and further identify PKC as a candidate therapeutic target
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Abstinence from alcohol consumption and exercise capacity: A pre and post intervention cohort study
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MetadataExtractorCron
No full textThis application goes daily over all resources in Coscine which have the Metadata Extraction activated and executes it. It is a metadata extractor that extracts metadata from files and stores it in a database. It is designed to be run as a cron job on a server. The extracted metadata includes information such as the title, author, and creation date of the PDF fileshttps://git.rwth-aachen.de/coscine/backend/scripts/metadataextractorcro
The Statement of Purpose in Applications to PhD Programs in Rhetoric and Composition: An Activity Theory Analysis
No full textThe applications process to PhD programs is complex, as signified by the number and variety of application requirements, including written texts. Of these texts, the statement of purpose in particular is regarded by recent scholarship as an occluded genre, one for which rhetorical purposes and resulting formal and content-related maneuvers are not apparent to applicants. This genre is a high-stakes genre in admissions to many PhD programs, acting as writing sample, evidence of disciplinary knowledge, and tentative proposal of future research. This thesis employs activity theory to investigate and analyze representative graduate programs\u27 admissions processes as activity systems and the role the statement of purpose plays in these systems. This role includes the ways the statement of purpose generates new texts and actions. The author makes both a nonspecific activity system model of admissions to PhD programs in rhetoric and composition and their use of the statement of purpose, and a contrastive model of one program and its use of the statement. The study\u27s findings demonstrate one potential cause of the occluded nature of the statement of purpose as a genre; that is, the expectations for and use of the genre in admissions practices vary from program to program, even within one discipline. Ultimately, this thesis examines the critical role student writing plays in the transition to a PhD program, concluding that the specific nature of this role is context-driven
Development and characterization of aptamer-conjugated imaging tools for diagnostic applications
No full textMagnetic resonance imaging (MRI) and computed tomography (CT) are imaging modalities commonly used to assess blood flow; however, neither can label a blood clot that may either disrupt flow, causing an ischemic stroke, or have the ability to demonstrate where a cerebral hemorrhage has occurred (hemorrhagic stroke). To improve the diagnosis and treatment of blood vessel diseases, such as stroke and aneurysms, we developed fibrinogen aptamer (FA)-functionalized contrast agents, enabling the identification and labelling of blood clots. Fibrin was chosen as the target of interest as it a major constituent of aforementioned conditions. Since FA was originally selected to bind fibrinogen, fibrin-binding validation was required. It was hypothesized that FA would retain some binding affinity towards the polymerized form, fibrin, given that most of the structural elements of fibrinogen remain unmodified in the final form. To assess the affinity and selectivity of FA towards non-solution-based fibrin, FA was tagged with a green emitting fluorophore and fluorescence co-localization was monitored. Solubilized fibrin was also used in a number of binding validation studies, including microscale thermophoresis, isothermal titration calorimetry, and circular dichroism. These techniques were used to calculate the apparent Kd, which was found to be within the acceptable range. Four different FA-targeted contrast materials were produced, including gadolinium conjugates (Gd(III)-DOTA/NOTA-FA) for MRI, iodinated-FA and FA-functionalized gold nanoparticles (FA-AuNPs) for CT, and FA-functionalized gold-coated iron-oxide nanoparticles (FA-Fe3O4-AuNPs) as dual-imaging agents for MRI and CT. All formulations were tested for their ability to produce significant contrast enhancement. In each case, when treated with aptamer-targeted formulations, contrast development was specific to the location of the clot. In MRI, T1- and T2-weighted scans revealed hyperintense contrast enhancement of fibrinogen in the blood pool and fibrin clots, respectively. In CT, both iodo-FA and FA-AuNPs showed high positive contrast enhancement, confirming that targeting minimizes dilution of the contrast material in the presence of the blood pool. FA-Fe3O4-AuNPs were successful in producing clot-specific hypointense contrast in MRI, allowing for delineation of clot parameters. However, CT imaging demonstrated that higher concentrations of the nanoparticles is required, and the thin gold coating is not sufficient to produce contrast enhancement
Contemporary flood management: Bound Brook, New Jersey
No full textDevelopment has been occurring within New Jersey along the Raritan River floodplain for centuries resulting in numerous fatalities and expensive property damage. In the last century, the U.S. Army Corps of Engineers (USACE) has been the leading task force to combat flooding within the Green Brook Sub-Basin of the Raritan River watershed through traditional flood control techniques. More specifically, Bound Brook, New Jersey has experienced frequent and recurrent flooding due to developmental pressure within the Raritan River floodplain. Unfortunately, flooding remained a centric issue in downtown Bound Brook moving into the twenty-first century.
The Green Brook Flood Control Project (GBFCP) was implemented in Bound Brook and the surrounding municipalities by the USACE to provide flood risk reduction for the borough, noting that not all floods would be eliminated. However, some community members perceived the GBFCP to be the ultimate answer that will stifle any future flood related threats. The GBFCP’s traditional flood control tactics provide the public with a false sense of hope by implementing static solutions to a complex flood issue that hinders the growth of ecological systems, and diminishes the community’s ecological identity.
This thesis explores flood management typologies in hopes to enhance environmental awareness by raising the question: How can the implementation of ecological design techniques within urban environments create adaptable and evolving flood risk management solutions while simultaneously fostering a human connection? To answer this question, Bound Brook, New Jersey’s history and developmental background, land use and topography, and flood control history were evaluated through mapping, diagrammatic modeling and observational studies to identify how the floodplain has been altered overtime and to recognize that there is still a potential flood threat. Academic research, case study review, and intervention valuation methods identified potential design solutions for Bound Brook’s flood management plan. Through these studies, Contemporary Flood Management: Bound Brook, New Jersey presents Bound Brook with a conceptual flood management design that cohesively reduces flood risk to human life by creating more room for water to flow, providing space for ecology to thrive, and linking humans back to their naturalized surroundings.M.L.A.Includes bibliographical reference
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