123,111 research outputs found
Jacques Kuster. L'Ordre des éléments et ses implications stylistiques dans la phrase des Homélies d'Ælfric comparée à celle des sermons de Wulfstan. Thèse de doctorat d’État soutenue à Paris IV, le 6 janvier 1978
No full textKuster Jacques. Jacques Kuster. L'Ordre des éléments et ses implications stylistiques dans la phrase des Homélies d'Ælfric comparée à celle des sermons de Wulfstan. Thèse de doctorat d’État soutenue à Paris IV, le 6 janvier 1978. In: Bulletin des anglicistes médiévistes, N°15, printemps 1979. p. 165
Oberflächenveränderung verschiedener zahnmedizinischer Werk-stoffe nach in-vitro Alterung
No full textSusceptibility of different restorative materials to toothbrush abrasion and coffee staining
Objective: The aim of this study was to evaluate the susceptibility of different restorative materials to surface alterations after an aging simulation.
Methods: Specimens (n=15 per material) of five different restorative materials (CER: ceramic/Vita Mark II; EMP: composite/Empress Direct; LAV: CAD/CAM composite/Lava Ultimate; COM: prefabricated composite/Componeer; VEN: prefabricated composite/Venear) were produced. Whereas CER was glazed, EMP and LAV were polished with silicon polishers, and COM and VEN were left untreated. Mean roughness (Ra and Rz) and colorimetric parameters (L*a*b*), expressed as colour change (E), were measured. The specimens underwent an artificial aging procedure. After baseline measurements (M1), the specimens were successively immersed for 24 hours in coffee (M2), abraded in a toothbrushing simulator (M3), immersed in coffee (M4), abraded (M5) and repeatedly abraded (M6). After each aging procedure (M2-M6), surface roughness and colorimetric parameters were recorded. Differences between the materials regarding Ra/Rz and E were analysed with a nonparametric ANOVA analysis. The level of significance was set at α=0.05.
Results: The lowest roughness values were obtained for CER. A significant increase in Ra was detected for EMP, COM and VEN compared to CER. The Ra/Rz values were found to be highly significantly different for the materials and measuring times (M) (p<0.0001). Regarding E most alterations were found for EMP and COM, whereas CER and LAV remained mostly stable. The E values were significantly different for the materials and M (p<0.0001).
Conclusion: The ceramic and the CAD/CAM composite were the most stable materials with regard to roughness and colour change and the only materials that resulted in Ra values below 0.2 μm (the clinically relevant threshold). Venears and Componeers were more inert than the direct composite material and thus might be an alternative for extensive restorations in the aesthetic zone
SHOX duplications found in some cases with type I Mayer-Rokitansky-Kuster-Hauser syndrome
No full textPurpose: The Mayer-Rokitansky-Kuster-Hauser syndrome is defined as congenital aplasia of mullerian ducts derived structures in females with a normal female chromosomal and gonadal sex. Most cases with Mayer-Rokitansky-Kuster-Hauser syndrome are sporadic, although familial cases have been reported. The genetic basis of Mayer-Rokitansky-Kuster-Hauser syndrome is largely unknown and seems heterogeneous, and a small number of cases were found to have mutations in the WNT4 gene. The aim of this study was to identify possible recurrent submicroscopic imbalances in a cohort of familial and sporadic cases with Mayer-Rokitansky-Kuster-Hauser syndrome. Methods: Multiplex ligation-dependent probe amplification was used to screen the subtelomeric sequences of all chromosomes in 30 patients with Mayer-Rokitansky-Kuster-Hauser syndrome (sporadic, n = 27 and familial, n = 3). Segregation analysis and pyrosequencing were applied to validate the MLPA results in the informative family. Results: Partial duplication of the Xpter pseudoautosomal region 1 containing the short stature homeobox (SHOX) gene was detected in five patients with Mayer-Rokitansky-Kuster-Hauser syndrome (familial, n = 3 and sporadic, n = 2) and not in 53 healthy controls. The duplications were not overlapping, and SHOX was never entirely duplicated. Haplotyping in the informative family revealed that SHOX gene duplication was inherited from the unaffected father and was absent in two healthy sisters. Conclusions: Partial duplication of SHOX gene is found in some cases with both familial and sporadic Mayer-Rokitansky-Kuster-Hauser type I syndrome
THE INFLUENCE OF INTERMOLECULAR VAN DER WAALS FORCES ON THE FORMATION OF ASSOCIATED MOLECULES
No full textNamen diplomske naloge je preučiti vpliv van der Waalsovih sil na tvorbo asociiranih molekul. V ta namen smo izbrali površinsko aktivne snovi, ki imajo amfifilne lastnosti in vplivajo na povšinske in medfazne napetosti ter pri določeni koncentraciji, imenovani kritična micelna koncentracija (CMC), tvorijo molekulske skupke, ki jim pravimo micele. Kritično micelno koncentracijo smo določili trem površinsko aktivnim snovem: heksadeciltrimetilamonijevemu bromidu, tetradeciltrimetilamonijevemu bromidu in n dodeciltrimetilamonijevemu bromidu. Eksperimente smo izvajali pri temperaturah 25 °C, 30 °C in 35 °C s klasično konduktometrično metodo. Na osnovi rezultatov smo analizirali vpliv van der Waalsovih sil na proces asociacije molekul v micele.
Za izbrano temperaturno območje smo ugotovili, da vrednosti kritične micelne koncentracije rastejo s povišanjem temperature in da se z višanjem števila C atomov v molekuli površinsko aktivne snovi kritične micelne koncentracije znižujejo. Po izračunu stopnje ionizacije micele α, stopnje vezave protiiona β in standardne Gibbsove proste energije pri micelizaciji 〖∆G〗_mic^°, smo ugotovili, da so vrednosti standardne Gibbsove proste energije pri micelizaciji v vseh primerih negativne in s podaljševanjem alkilne verige v molekuli padajo, kar si razlagamo kot krepitev privlačnih van der Waalsovih sil, ki posledično povzročijo nastanek micele pri nižji vrednosti kritične micelne koncentracije.The aim of the diploma thesis was to investigate the influence of van der Waals forces on formation of the associated molecules. For this purpose we chose surface active agents, which have amphiphilic properties and they affect on surface and interface tensions and on the certain concentration, called critical micelle concentration (CMC), they form molecular assemblies, known as micelles. We determined critical micelle concentration to three surfactants: hexadecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide and n-dodecyltrimethylammonium bromide. We executed the experiment at temperatures 25 °C, 30 °C and 35 °C with clasic conductometry method. On the basis of the results, we analysed the influence of van der Waals forces on the process of association of molecules to micelles.
For chosen temperature range, we found out, that values of critical micelle concentration increase with increasing temperature and with the extension of the number of C atoms in molecule of surfactant critical micelle concentration decreases. According to calculation of ionization degree α, degree of binding counterion β and standard Gibbs energy of micellization 〖∆G〗_mic^°, we found out, that values of standard Gibbs energy of micellization are in all cases negative and with extending alkyl chain in molecule, decrease, what we explain as enhancement of attractive van der Waals forces, which consequentially cause formation of micelle at lower value of critical micelle concentration
NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling
No full textModerate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS are protective in the heart.
In this study we show that CD29 (β1-integrin), a cell adhesion receptor highly expressed on cardiac muscle cells, induces NOX-dependent ROS. CD29 is known to be mandatory in cell growth and survival, and non-functional CD29 causes severe heart disease. We demonstrate that NOX2-derived ROS are essential for CD29-induced survival signalling, including the PI3K/PKB and MEK/ERK pathways. Furthermore, CD29-induced NOX-derived ROS are indispensible in the inhibition of the pro-apoptotic kinase GSK-3β, which we uncovered as a downstream target of both the ERK and PKB survival pathways in cardiac muscle cells. These findings clearly add to the growing body of evidence suggesting that moderate ROS levels are beneficial to the cell and highlight the crucial role of NOX2-derived ROS for cell survival in the heart
Beratung nutzen zur Schulentwicklung
No full textFaix A-C, Kuster R, Anderegg N, eds. Beratung nutzen zur Schulentwicklung. Lernende Schule. Vol 104. Hannover: Friedrich Verlag; 2023
Gonadal Dysgenesis 46, XX Associated with Mayer-Rokitansky-Kuster-Hauser Syndrome: One Case Report
No full textIntroduction. The association of gonadal dysgenesis and Mayer-Rokitansky-Kuster-Hauser syndrome is very rare and appears to be coincidental, independent of chromosomal anomalies. Case Report. We report the case of a 19-year-old woman who presented primary amenorrhea and impuberism. The endocrine study revealed hypergonadotrophic hypogonadism. The karyotype was normal, 46XX. No chromosome Y was detected at the FISH analysis. Internal genitalia could not be identified on the pelvic ultrasound and pelvic MRI. Laparoscopy was undertaken and revealed concomitant ovarian dysgenesis and Mayer-Rokitansky-Kuster-Hauser syndrome. There were no other morphological malformations. Conclusion. The pathogenesis of the association of gonadal dysgenesis and Mayer Rokitansky kuster hauser syndrome is still mysterious. The treatment is based essentially on hormone substitution therapy. The fertility prognosis is unfortunately compromised
Recherches suisses sur les ongules-gibier
No full textBurckardt Dieter, Kuster A., Schlœth Robert. Recherches suisses sur les ongules-gibier. In: La Terre et La Vie, Revue d'Histoire naturelle, tome 15, n°1, 1961. pp. 101-109
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