4,874 research outputs found
Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides
No full textA library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol-water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10+ mg scale. © 2007 American Chemical Society.Butler MS, 2004, J NAT PROD, V67, P2141, DOI 10.1021-np040106y; Grimmet M. R., 1997, COMPREHENSIVE ORGANI, V4, P357; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; Kurth MJ, 2005, J ORG CHEM, V70, P1060, DOI 10.1021-jo048153i; Luo GL, 2006, J ORG CHEM, V71, P5392, DOI 10.1021-jo060607j; Miertus S., 1999, COMBINATORIAL CHEM T; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Padwa A., 1994, PROG HETEROCYCL CHEM, V6, P36; SHIRTCLIFF LD, 2006, IN PRESS J AM CHEM S, V128; SHIRTCLIFF LD, 2006, IN PRESS J ORG CHEM, V71; Stadlbauer W., 2002, SCI SYNTH, V12, P227; Thompson LA, 1996, CHEM REV, V96, P555, DOI 10.1021-cr940208116141
Claimed 2,1-benzisoxazoles are indazalones
No full text(Chemical Equation Presented) Claims, by two groups, to have prepared 2,1-benzisoxazole derivatives are corrected to show that the products are indazalones (5). In addition, a simple preparation of 3-oxysubstituted 2H-indazole, by an unrecognized method in the literature, is reported.ARAN VJ, 1997, TETRAHEDRON, V45, P129; Bamberger E., 1918, CHEM BER, V51, P606; Bjorsvik HR, 2004, J ORG CHEM, V69, P7720, DOI 10.1021-jo049102o; Boduszek B, 1997, TETRAHEDRON, V53, P11399, DOI 10.1016-S0040-4020(97)00721-7; Chen LJ, 1998, TETRAHEDRON LETT, V39, P5351, DOI 10.1016-S0040-4039(98)01068-5; HADDADIN MJ, UNPUB; ISHIKAWA F, 1980, CHEM PHARM BULL, V28, P1357; Stadlbauer W., 2002, SCI SYNTH, V12, P22721212
Facile Syntheses of Novel Benzo-1,3-dioxolo-, Benzothiazolo-, Pyrido-, and Quinolino-fused 5 H -Benzo[ d ]-pyrazolo[5,1-b ][1,3]-oxazines and 1 H -Pyrazoles
No full textA number of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles were synthesized utilizing an easy and effective N,N-bond forming heterocyclization reaction. In so doing, the substrate scope of this heterocyclization reaction, which starts with o-nitroheterocyclic aldehydes, was expanded to provide several unique heterocyclic compounds for biological screening. This work further demonstrates the versatility of this simple, base-mediated, one-pot heterocyclization method in the construction of novel heterocycles.(Figure Presented) © 2011 American Chemical Society.BENEDINI F, 1995, J MED CHEM, V38, P130, DOI 10.1021-jm00001a018; Butler JD, 2008, J ORG CHEM, V73, P234, DOI 10.1021-jo702067z; CHAPMAN D, 1980, J CHEM SOC PERK T 1, P2398, DOI 10.1039-p19800002398; Cho YS, 2010, J MED CHEM, V53, P7938, DOI 10.1021-jm100571n; CLARK RD, 1983, J MED CHEM, V26, P657, DOI 10.1021-jm00359a007; Couch GD, 2008, TETRAHEDRON, V64, P2816, DOI 10.1016-j.tet.2008.01.043; FOSTER HE, 1973, J CHEM SOC PERK T 1, P319, DOI 10.1039-p19730000319; GODARD A, 1980, J HETEROCYCLIC CHEM, V17, P465; Heller ST, 2007, ORG LETT, V9, P4947, DOI 10.1021-ol701784w; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; HURST J, 1968, J CHEM SOC C, P1487, DOI 10.1039-j39680001487; Katritzky AR, 2000, J HETEROCYCLIC CHEM, V37, P1655; Kim D, 2001, BIOORG MED CHEM LETT, V11, P3103, DOI 10.1016-S0960-894X(01)00655-2; Kurth MJ, 2005, J ORG CHEM, V70, P1060, DOI 10.1021-jo048153i; MAKOSZA M, 1987, TETRAHEDRON LETT, V28, P3021; Matsuoka H, 1997, J MED CHEM, V40, P105, DOI 10.1021-jm9605288; Matveev MR, 2001, RUSS J GEN CHEM+, V71, P1286, DOI 10.1023-A:1013241516204; Mills AD, 2007, J COMB CHEM, V9, P171, DOI 10.1021-cc060109o; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Niu CS, 1998, TETRAHEDRON, V54, P6311, DOI 10.1016-S0040-4020(98)00328-7; Oakdale JS, 2009, ORG LETT, V11, P2760, DOI 10.1021-ol900891s; Schmidt A, 2008, EUR J ORG CHEM, P4073, DOI 10.1002-ejoc.200800227; Solano D. M., 2010, ORG SYNTH, V87, P339; Stadlbauer W., 2002, SCI SYNTH, V12, P227; VETELINO MG, 1994, TETRAHEDRON LETT, V35, P219, DOI 10.1016-S0040-4039(00)76515-4; Wu CR, 2010, ORG LETT, V12, P2234, DOI 10.1021-ol100586r; Yan MC, 2004, J ORG CHEM, V69, P1565, DOI 10.1021-jo030070z; Zhu GD, 2007, J MED CHEM, V50, P2990, DOI 10.1021-jm070101915161
The Davis-Beirut reaction: N 1, N 2-disubstituted-1 H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2 H-indazoles
No full textA variety of electrophiles (anhydrides, acid chlorides, carbonochloridates, sulfonyl chlorides, and alkyl bromides) react with 3-methoxy-2H-indazole (1a), benzoxazin[3,2-b]indazole (1d), and oxazolino[3,2-b]indazole (1e) - substrates available by the Davis-Beirut reaction - to yield a diverse set of N 1,N2-disubstituted-1H-indazolones. With certain electrophiles, an AERORC (Addition of the Electrophile, Ring Opening, and Ring Closure) process on indazole 1d results in indazoloindazolone formation. An intriguing aspect of these N1,N2-disubstituted-1H- indazolones is that they are poised for diversification through, for example, azide-alkyne cycloaddition chemistry reported here. © 2011 American Chemical Society.Avila B, 2011, ORG LETT, V13, P1060, DOI 10.1021-ol103108z; Butler JD, 2008, J ORG CHEM, V73, P234, DOI 10.1021-jo702067z; Cerecetto H, 2005, MINI-REV MED CHEM, V5, P869, DOI 10.2174-138955705774329564; Donald MB, 2010, ORG LETT, V12, P2524, DOI 10.1021-ol100751n; ELGUERO I, 1996, COMPREHENSIVE HETERO, V3, P1; Feldman AK, 2004, ORG LETT, V6, P3897, DOI 10.1021-ol048859z; Goddard-Borger ED, 2007, ORG LETT, V9, P3797, DOI 10.1021-ol701581g; Halland N, 2009, ANGEW CHEM INT EDIT, V48, P6879, DOI 10.1002-anie.200902323; Hein JE, 2010, CHEM SOC REV, V39, P1302, DOI 10.1039-b904091a; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; Kawanishi N, 2006, BIOORG MED CHEM LETT, V16, P5122, DOI 10.1016-j.bmcl.2006.07.026; Kurth MJ, 2005, J ORG CHEM, V70, P1060, DOI 10.1021-jo048153i; Liu YX, 2010, J AGR FOOD CHEM, V58, P2685, DOI 10.1021-jf902541w; Meldal M, 2008, CHEM REV, V108, P2952, DOI 10.1021-cr0783479; Mills AD, 2007, J COMB CHEM, V9, P171, DOI 10.1021-cc060109o; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Oakdale JS, 2009, ORG LETT, V11, P2760, DOI 10.1021-ol900891s; Fletcher SR, 2006, BIOORG MED CHEM LETT, V16, P2872, DOI 10.1016-j.bmcl.2006.03.004; Rostovtsev VV, 2002, ANGEW CHEM INT EDIT, V41, P2596, DOI 10.1002-1521-3773(20020715)41:142596::AID-ANIE25963.0.CO;2-4; Schmidt A, 2008, EUR J ORG CHEM, P4073, DOI 10.1002-ejoc.200800227; Solano D. M., 2010, ORG SYNTH, V87, P339; Stadlbauer W., 2002, SCI SYNTH, V12, P227; Tornoe CW, 2002, J ORG CHEM, V67, P3057, DOI 10.1021-jo011148j; VANDERPLAS HC, 1978, ACCOUNTS CHEM RES, V11, P462, DOI 10.1021-ar50132a005; van der Plas HC, 1999, ADV HETEROCYCL CHEM, V74, P1; Vina D, 2007, ORG LETT, V9, P525, DOI 10.1021-ol062890e12131
Vacuum Insulation Panels Applied in Building Constructions
No full textDue to sustainability and due to international treaties, it is desired and required to reduce greenhouse gas emissions drastically. One contributor to these emissions is the burning of fossil fuels for generating power and electricity to be used in and for buildings. Buildings and building-related processes are responsible for about 40% of the primary energy consumption in the European Union. More than half of this energy is applied for heating systems in dwellings and commercial buildings. The European Union therefore has laid down new energy performance requirements for buildings in the European Directive on the Energy Performance of Buildings. Moreover, a reduction of energy losses of buildings during their occupational phase is important for facilitating the implementation of sustainable energy sources in the built environment. Increasing the insulation value of the envelope of buildings may contribute to this reduction of primary energy use. Two strategies can be followed. The first strategy is to increase the thickness of the thermal insulation layer. Until recently, this strategy has primarily been adopted. If, however, German or Swiss Passivhaus standard is applied, the thickness of this insulation layer would increase to beyond 30 cm, resulting in very thick building enclosures. The second, more innovative, strategy for reducing energy losses through the building skin would be the application of more effective thermal insulators. One such more effective thermal insulator is a vacuum insulation panel, abbreviated as VIP. A VIP consists of an open-celled core material which is evacuated and then tightly sealed into a barrier envelope to maintain this vacuum. The vacuum inside the pores of the core material reduces the thermal conductivity of the product significantly, as a result of which the thickness of the insulation layer can be reduced to obtain a certain performance. This reduction of thickness is among the most promising features for large-scale application of VIPs in the building industry. However, integration of VIPs into buildings must be performed very meticulously for several reasons; first, due to its nature a VIP cannot be processed on site and needs careful planning in advance; second, it is very sensitive to mechanical damage thus requiring careful handling; third, thermal bridges along the panel’s edges reduce its performance; fourth, the composite system is highly subjected to aging. This dissertation therefore looks into many of these aspects, presents several calculation tools and shows how VIPs can be applied in façade panels, EPS insulation boards and as under-floor insulation. With the wide-spread proliferation of VIPs in buildings a more sustainable and healthy environment can then be achieved.Building TechnologyArchitectur
Acid and base catalyzed Davis-Beirut reaction: Experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles
No full textThe Davis-Beirut reaction, which provides an efficient synthesis of 2H-indazoles and, subsequently, indazolones, is shown to proceed rapidly from o-nitrosobenzaldehyde and primary amines under both acid and base catalysis. Experimental and theoretical evidence in support of a reaction mechanism is provided in which o-nitrosobenzylidine imine is a pivotal intermediate in this N,N-bond forming heterocyclization reaction. The Davis-Beirut reaction is also shown to effectively synthesize a number of novel 3-amino-2H-indazole derivatives. © 2012 Elsevier Ltd. All rights reserved.Avila B, 2011, ORG LETT, V13, P1060, DOI 10.1021-ol103108z; Bamberger E., 1918, CHEM BER, V51, P606; Butler JD, 2008, J ORG CHEM, V73, P234, DOI 10.1021-jo702067z; Cankarova N, 2010, ORG PREP PROCED INT, V42, P433, DOI 10.1080-00304948.2010.513898; Chen LJ, 1998, TETRAHEDRON LETT, V39, P5351, DOI 10.1016-S0040-4039(98)01068-5; Conrad W. E., 2011, ORG LETT, V13, P2141; Conrad WE, 2012, ORG LETT, V14, P3870, DOI 10.1021-ol3015804; De Angelis M, 2005, J MED CHEM, V48, P1132, DOI 10.1021-jm049223g; DEWAR MJS, 1984, J AM CHEM SOC, V106, P209, DOI 10.1021-ja00313a042; Donald MB, 2010, ORG LETT, V12, P2524, DOI 10.1021-ol100751n; Haddadin MJ, 2012, MINI-REV MED CHEM, V12, P1293; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; Jung N., 2010, SCI SYNTH, V41, P613; Kurth MJ, 2005, J ORG CHEM, V70, P1060, DOI 10.1021-jo048153i; Mills AD, 2007, J COMB CHEM, V9, P171, DOI 10.1021-cc060109o; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Oakdale JS, 2009, ORG LETT, V11, P2760, DOI 10.1021-ol900891s; Schmidt A, 2008, EUR J ORG CHEM, P4073, DOI 10.1002-ejoc.200800227; Solano D. M., 2010, ORG SYNTH, V87, P339; Stadlbauer W., 2002, SCI SYNTH, V12, P227; Tantillo DJ, 2008, J PHYS ORG CHEM, V21, P561, DOI 10.1002-poc.1320; Williams A., 2000, CONCERTED ORGANIC BI; Wu CR, 2010, ORG LETT, V12, P2234, DOI 10.1021-ol100586r23
Transannular anti-Michael addition: formation of 4H-pyrazolo[5,1-c]thiazines
No full textThe reaction of 2-(diphenylmethylene)thietan-3-one (2) with 1,2,4,5-tetrazines (3a-c) in KOH-MeOH-THF gives 4H-pyrazolo[5,1-c]thiazines (7a-c). This novel condensation reaction proceeds via the intermediacy of an 8-(diphenylmethylene)-2H-1,4,5-thiadiazocin-7(8H)-one (5), which undergoes a multi-step rearrangement including a rare anti-Michael addition. © 2006 Elsevier Ltd. All rights reserved.AMORESE A, 1989, TETRAHEDRON, V45, P813, DOI 10.1016-0040-4020(89)80112-7; Back TG, 1998, J ORG CHEM, V63, P7908, DOI 10.1021-jo981224r; BACK TG, 1995, TETRAHEDRON LETT, V36, P4737; Genin MJ, 2000, J MED CHEM, V43, P1034, DOI 10.1021-jm990383f; GEROLD A, 1994, CHEM BER, V127, P1547, DOI 10.1002-cber.19941270833; HADDAM MJ, 1984, TETRAHEDRON LETT, V54, P2577; Khlebnikov AF, 2005, ORG BIOMOL CHEM, V3, P4040, DOI 10.1039-b512409c; KLUMPP GW, 1985, J AM CHEM SOC, V107, P6740, DOI 10.1021-ja00309a070; KRUBSACK AJ, 1970, J AM CHEM SOC, V92, P5258, DOI 10.1021-ja00720a065; Marala RB, 2002, EUR J PHARMACOL, V451, P37, DOI 10.1016-S0014-2999(02)02193-3; MARTIN V, 1992, J ORG CHEM, V57, P5530, DOI 10.1021-jo00046a042; Penning TD, 1997, J MED CHEM, V40, P1347, DOI 10.1021-jm960803q; Peruncheralathan S, 2005, J ORG CHEM, V70, P10030, DOI 10.1021-jo051771u; Robins LI, 2006, J ORG CHEM, V71, P2480, DOI 10.1021-jo052577a; RUDORF WD, 1993, SYNLETT, P369; SHELDRICK GM, 1997, CRYSTALLOGRAPHIC DAT; Suen YF, 2005, J ORG CHEM, V70, P8468, DOI 10.1021-jo051319a; Takemura I, 2006, TETRAHEDRON LETT, V47, P6677, DOI 10.1016-j.tetlet.2006.06.07986
A novel route to fully substituted 1H-pyrazoles
No full textA novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products. © 2005 American Chemical Society.BOGER DL, 1986, CHEM REV, V86, P781, DOI 10.1021-cr00075a004; Broughton HB, 2004, J MOL GRAPH MODEL, V23, P51, DOI 10.1016-j.jmgm.2004.03.016; Churakov AM, 2004, CHEM REV, V104, P2601, DOI 10.1021-cr020094q; COHEN VI, 1978, J HETEROCYCLIC CHEM, V15, P1113; FISCHER HP, 1994, B SOC CHIM BELG, V103, P565; Genin MJ, 2000, J MED CHEM, V43, P1034, DOI 10.1021-jm990383f; Giubellina N, 2003, PURE APPL CHEM, V75, P1433, DOI 10.1351-pac200375101433; HADDADIN MJ, 1979, J ORG CHEM, V44, P629, DOI 10.1021-jo01318a032; HADDADIN MJ, 1984, TETRAHEDRON LETT, V25, P2577, DOI 10.1016-S0040-4039(01)81235-1; HANEFELD W, 1982, ARCH PHARM, V315, P57, DOI 10.1002-ardp.19823150113; Hu WX, 2004, BIOORG MED CHEM LETT, V14, P1177, DOI 10.1016-j.bmcl.2003.12.056; Hurst DT, 1998, PROG HET CH, V10, P275; KRUBSACK AJ, 1970, J AM CHEM SOC, V92, P5258, DOI 10.1021-ja00720a065; Norris T, 2005, ORG BIOMOL CHEM, V3, P1844, DOI 10.1039-b500413f; Penning TD, 1997, J MED CHEM, V40, P1347, DOI 10.1021-jm960803q; Guzman-Perez A, 2001, BIOORG MED CHEM LETT, V11, P803, DOI 10.1016-S0960-894X(01)00059-2; Pillai AD, 2005, BIOORGAN MED CHEM, V13, P1275, DOI 10.1016-j.bmc.2004.11.016; Sauer J., 1996, COMPREHENSIVE HETERO, P901; SAUER J, 1996, COMP HETEROCYCL CHEM, V6, P1177; SCHMIDT RR, 1975, TETRAHEDRON LETT, V16, P33, DOI 10.1016-S0040-4039(00)71770-9; SEITZ G, 1977, ARCH PHARM, V310, P269, DOI 10.1002-ardp.19773100316; SEITZ G, 1984, ANGEW CHEM INT EDIT, V23, P890, DOI 10.1002-anie.198408901; SHELDRICK GM, 1997, BRUKER SMART APEX 2; Soloducho J, 2003, TETRAHEDRON, V59, P4761, DOI 10.1016-S0040-4020(03)00709-9; STUCKY GC, 1996, SPEC CHEM, V16, P256; Vullo D, 2005, BIOORG MED CHEM LETT, V15, P971, DOI 10.1016-j.bmcl.2004.12.05224222
A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular bis-heterocyclizations
No full text(Chemical Equation Presented) The parent 5H-indazolo[3,2-b]benzo[d]-1,3- oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening. © 2008 American Chemical Society.ALABASTER CT, 1988, J MED CHEM, V31, P2048, DOI 10.1021-jm00118a034; ALKHADER MA, 1980, SYNTHESIS-STUTTGART, P381; Ando Y, 2006, BIOORG MED CHEM LETT, V16, P5849, DOI 10.1016-j.bmcl.2006.08.064; Anwar HF, 2007, TETRAHEDRON, V63, P9997, DOI 10.1016-j.tet.2007.07.064; Basheer A, 2006, J ORG CHEM, V71, P9743, DOI 10.1021-jo061835g; BENEDINI F, 1995, J MED CHEM, V38, P130, DOI 10.1021-jm00001a018; Cheng CY, 2005, CONTRACEPTION, V72, P251, DOI 10.1016-j.contraception.2005.03.008; CLARK RD, 1983, J MED CHEM, V26, P657, DOI 10.1021-jm00359a007; Goodman KB, 2007, J MED CHEM, V50, P6, DOI 10.1021-jm0609014; Heydenreich M, 2006, TETRAHEDRON, V62, P11081, DOI 10.1016-j.tet.2006.09.037; HOBACK JH, 1955, U B SER, V56, P40; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; Kantorowski EJ, 1998, J ORG CHEM, V63, P5272, DOI 10.1021-jo980411m; Kim D, 2001, BIOORG MED CHEM LETT, V11, P3103, DOI 10.1016-S0960-894X(01)00655-2; Kiskan B, 2007, J POLYM SCI POL CHEM, V45, P1670, DOI 10.1002-pola.21934; Koshio H, 2005, BIOORGAN MED CHEM, V13, P1305, DOI 10.1016-j.bmc.2004.11.005; Li JR, 2006, J HETEROCYCLIC CHEM, V43, P745; Matsuoka H, 1997, J MED CHEM, V40, P105, DOI 10.1021-jm9605288; Mills AD, 2007, J COMB CHEM, V9, P171, DOI 10.1021-cc060109o; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Mruk DD, 2006, NAT MED, V12, P1323, DOI 10.1038-nm1420; Nicolaou KC, 2005, ANGEW CHEM INT EDIT, V44, P4442, DOI 10.1002-anie.200500368; Pietsch M, 2005, J MED CHEM, V48, P8270, DOI 10.1021-jm0508639; Sicker D, 2002, STUDIES NATURAL PROD, V27, P185; Spagnol G, 2007, J ORG CHEM, V72, P1867, DOI 10.1021-jo062670e; Stadlbauer W., 2002, SCI SYNTH, V12, P227; WAGNER G, 1957, Arch Pharm Ber Dtsch Pharm Ges, V290-62, P520, DOI 10.1002-ardp.19572901103; Yadav LDS, 2007, SYNLETT, P1227, DOI 10.1055-s-2007-97744024232
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles
No full textA one-pot-three-step method has been developed for the conversion of oxazolino-2H-indazoles into triazolotriazepinoindazolones with three points of diversity. Step one of this process involves a propargyl bromide-initiated ring opening of the oxazolino-2H-indazole (available by the Davis-Beirut reaction) to give an N1-(propargyl)-N2-(2-bromoethyl)-disubstituted indazolone, which then undergoes -CH2Br → -CH2N 3 displacement (step two) followed by an uncatalyzed intramolecular azide-alkyne 1,3-dipolar cycloaddition (step three) to form the target heterocycle. Employing 7-bromooxazolino-2H-indazole allows for further diversification through, for example, palladium-catalyzed coupling chemistry, as reported here. © 2012 American Chemical Society.Abouzid KAM, 2003, ARCH PHARM RES, V26, P1; Angela R.K., 2012, ORG LETT, V14, P1804; Avila B, 2011, ORG LETT, V13, P1060, DOI 10.1021-ol103108z; Brodie MJ, 2009, EPILEPSIA, V50, P1899, DOI 10.1111-j.1528-1167.2009.02160.x; Butler JD, 2008, J ORG CHEM, V73, P234, DOI 10.1021-jo702067z; Callam CS, 2001, J CHEM EDUC, V78, P947; Cappelli A, 2008, J MED CHEM, V51, P2137, DOI 10.1021-jm7011563; Cerecetto H, 2005, MINI-REV MED CHEM, V5, P869, DOI 10.2174-138955705774329564; Conrad WE, 2011, ORG LETT, V13, P3138, DOI 10.1021-ol2010424; Dandapani S, 2010, CURR OPIN CHEM BIOL, V14, P362, DOI 10.1016-j.cbpa.2010.03.018; Donald JR, 2011, ORG LETT, V13, P852, DOI 10.1021-ol1028404; Donald MB, 2010, ORG LETT, V12, P2524, DOI 10.1021-ol100751n; Gupta M, 2011, EUR J MED CHEM, V46, P631, DOI 10.1016-j.ejmech.2010.11.043; Hann MM, 2004, CURR OPIN CHEM BIOL, V8, P255, DOI 10.1016-j.cbpa.2004.04.003; Hartwig J.F., 1998, ANGEW CHEM INT EDIT, V37, P2046, DOI DOI 10.1002-(SICI)1521-3773(19980817)37:152046::AID-ANIE20463.0.CO; Huang LJ, 2006, BIOORGAN MED CHEM, V14, P528, DOI 10.1016-j.bmc.2005.08.032; Huuf B.E., 1997, ORG SYN, V75, P53; Kawanishi N, 2006, BIOORG MED CHEM LETT, V16, P5122, DOI 10.1016-j.bmcl.2006.07.026; Khalil AM, 2009, EUR J MED CHEM, V44, P4448, DOI 10.1016-j.ejmech.2009.06.003; Kharb R, 2011, J ENZYM INHIB MED CH, V26, P1, DOI 10.3109-14756360903524304; Kurth MJ, 2005, J ORG CHEM, V70, P1060, DOI 10.1021-jo048153i; Lipinski CA, 1997, ADV DRUG DELIVER REV, V23, P3, DOI 10.1016-S0169-409X(96)00423-1; Majumdar K. C., 2011, SYNTHESIS-STUTTGART, V23, P3767; Mills AD, 2007, J COMB CHEM, V9, P171, DOI 10.1021-cc060109o; Mills AD, 2006, J ORG CHEM, V71, P2687, DOI 10.1021-jo0524831; Miyura N., 1995, CHEM REV, V95, P2457; Oakdale JS, 2009, ORG LETT, V11, P2760, DOI 10.1021-ol900891s; Oliva AI, 2008, ORG LETT, V10, P1617, DOI 10.1021-ol800291t; Fletcher SR, 2006, BIOORG MED CHEM LETT, V16, P2872, DOI 10.1016-j.bmcl.2006.03.004; Ryng S, 2005, PHARMACOL REP, V57, P195; Sankaran M, 2010, BIOORG MED CHEM LETT, V20, P7147, DOI 10.1016-j.bmcl.2010.09.018; Solano D.M., 2010, J ORG SYNTH, V87, P339; Tan DS, 2005, NAT CHEM BIOL, V1, P74, DOI 10.1038-nchembio0705-74; Walters WP, 2003, NAT REV DRUG DISCOV, V2, P259, DOI 10.1038-nrd1063; Wang H, 2006, CANCER RES, V66, P9722, DOI 10.1158-0008-5472.CAN-05-4602; Wolfe JP, 2000, J ORG CHEM, V65, P1144, DOI 10.1021-jo9916986; Wolfe JP, 1998, ACCOUNTS CHEM RES, V31, P805, DOI 10.1021-ar960065010111
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