1,047 research outputs found
GATA-1 and Gfi-1B Interplay to Regulate Bcl-xL Transcription. GATA-1 and Gfi-1B Interplay to Regulate Bcl-xL Transcription.
No full textPandemic influenza H1N1 vaccination intention: psychosocial determinants and implications from a national survey, Taiwan.
No full textAbstract
BACKGROUND:
Vaccination has been recommended as an effective way to protect people from severe illness during influenza pandemics; however, little is known about the acceptability and psychosocial determinants of intention to receive vaccination against pandemic influenza A/H1N1 (pH1N1).
METHODS:
A national computer-assisted telephone interview survey using random digit dialing was conducted during 28-30 October 2009 among residents of Taiwan aged ≥15 years.
RESULTS:
Of the 1079 participants interviewed, 70.1% reported intention to receive pH1N1 vaccination. Multivariate logistic regression analysis showed that participants who perceived pH1N1 in Taiwan to be much more severe than that in other countries [adjusted odds ratio (AOR)=1.94; 95% confidence interval (CI)=1.05-3.60], who agreed (AOR=2.44; 95% CI=1.30-4.58) or strongly agreed (AOR=2.53; 95% CI=1.38-4.65) that contracting pH1N1 would have a great impact on their daily life, who perceived pH1N1 vaccination to be very effective in preventing pH1N1 (AOR=2.64; 95% CI=1.61-4.33) and who considered receiving vaccination not very difficult (AOR=8.97; 95% CI=6.05-13.29) or not at all difficult (AOR=30.72; 95% CI=19.24-49.04) were more inclined towards getting vaccinated against pH1N1.
CONCLUSION:
These specific and modifiable health beliefs have practical implications for prevention and policy making, and highlight the importance of minimizing perceived barriers while convincing the public of the seriousness of the disease and effectiveness of vaccination when promoting vaccination programmes
Quantitative study of [(pF)Phe4,Arg14,Lys15]nociceptin/orphanin FQ-NH2 (UFP-102) at NOP receptors in rat periaqueductal gray slices.
No full textControl of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability
No full textNeglected esophageal injury presenting with spontaneously shrunken retroesophageal pocket
No full textColor doppler ultrasonography in detecting transdiaphragmatic flow of hepatic hydrothorax: correlated with thoracoscopic findings
No full textRecommended from our members
Differential Effects of Two Fermentable Carbohydrates on Central Appetite Regulation and Body Composition
Full text linkBackground: Obesity is rising at an alarming rate globally. Different fermentable carbohydrates have been shown to reduce obesity. The aim of the present study was to investigate if two different fermentable carbohydrates (inulin and β-glucan) exert similar effects on body composition and central appetite regulation in high fat fed mice. Methodology/Principal Findings: Thirty six C57BL/6 male mice were randomized and maintained for 8 weeks on a high fat diet containing 0% (w/w) fermentable carbohydrate, 10% (w/w) inulin or 10% (w/w) β-glucan individually. Fecal and cecal microbial changes were measured using fluorescent in situ hybridization, fecal metabolic profiling was obtained by proton nuclear magnetic resonance (1H NMR), colonic short chain fatty acids were measured by gas chromatography, body composition and hypothalamic neuronal activation were measured using magnetic resonance imaging (MRI) and manganese enhanced MRI (MEMRI), respectively, PYY (peptide YY) concentration was determined by radioimmunoassay, adipocyte cell size and number were also measured. Both inulin and β-glucan fed groups revealed significantly lower cumulative body weight gain compared with high fat controls. Energy intake was significantly lower in β-glucan than inulin fed mice, with the latter having the greatest effect on total adipose tissue content. Both groups also showed an increase in the numbers of Bifidobacterium and Lactobacillus-Enterococcus in cecal contents as well as feces. β- glucan appeared to have marked effects on suppressing MEMRI associated neuronal signals in the arcuate nucleus, ventromedial hypothalamus, paraventricular nucleus, periventricular nucleus and the nucleus of the tractus solitarius, suggesting a satiated state. Conclusions/Significance: Although both fermentable carbohydrates are protective against increased body weight gain, the lower body fat content induced by inulin may be metabolically advantageous. β-glucan appears to suppress neuronal activity in the hypothalamic appetite centers. Differential effects of fermentable carbohydrates open new possibilities for nutritionally targeting appetite regulation and body composition
Quantitative study of [(pF)Phe(4),Arg(14),Lys(15)]nociceptin/orphanin FQ-NH(2) (UFP-102) at NOP receptors in rat periaqueductal gray slices
No full textThe nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a novel member of the opioid receptor family with little affinity for traditional opioids. This receptor and its endogenous ligand, N/OFQ, are widely distributed in the brain and are implicated in many physiological functions including pain regulation. [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102) is a newly developed peptide agonist of NOP receptors. In this study, we quantitatively investigated the effect of UFP-102 at native NOP receptors of the ventrolateral periaqueductal gray (PAG), a crucial midbrain area involved in pain regulation and enriched with NOP receptors, using blind patch-clamp whole-cell recording technique in rat brain slices. UFP-102, like N/OFQ, induced an outward current in ventrolateral PAG neurons and increased the membrane current elicited by a hyperpolarization ramp from -60 to -140 mV. The current induced by UFP-102 was characterized with inward rectification and had a reversal potential near the equilibrium potential of K(+) ions, indicating that UFP-102 activates G-protein coupled inwardly rectifying K(+) channels. The effect of UFP-102 was concentration-dependent with the maximal effect similar to that of N/OFQ. The EC(50) value was 11+/-2 nM, which is 5 fold lower than that of N/OFQ. The effect of UFP-102 was not affected by naloxone while competitively antagonized by UFP-101 ([Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2)), a potent NOP receptor antagonist, with a pA(2) value of 6.7. These results suggest that UFP-102 is a full agonist at the postsynaptic NOP receptors of the midbrain of rats and is 5 fold more potent than N/OFQ
Herpes-like virus infection causing mortality of cultured abalone Haliotis diversicolor supertexta in Taiwan.
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