76,260 research outputs found
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Supplementary Materials: Kuo et al., How Students Blend Conceptual and Formal Mathematical Reasoning in Solving Physics Problems, accepted for publication in Science Education on 08/08/2012
Full text linkThis is supplemental material pertaining to the qualitative data presented in the manuscript:
Kuo. E., Hull, M. M., Gupta, A., & Elby, A., How Students Blend Conceptual and Formal Mathematical Reasoning in Solving Physics Problems, accepted for publication in Science Education on 08/08/2012.
The following material consists of 4 parts:
A. The context of the study (p. 2)
B. The question protocol that students were asked to answer. (pp. 3-4)
C. The transcript of Alex’s interview (pp. 5-17)
D. The transcript of Pat’s interview (pp. 18-31
sj-pdf-1-aor-10.1177_00034894211045264 – Supplemental material for The efficacy of Tranexamic Acid Administration in Patients Undergoing Tonsillectomy: An Updated Meta-Analysis
No full textSupplemental material, sj-pdf-1-aor-10.1177_00034894211045264 for The efficacy of Tranexamic Acid Administration in Patients Undergoing Tonsillectomy: An Updated Meta-Analysis by Cathleen C. Kuo, Jason C. DeGiovanni and Michele M. Carr in Annals of Otology, Rhinology & Laryngology</p
Murina gracilis Kuo Haochih 2009
No full text365. Gracile Tube-nosed Bat Murina gracilis French: Murine gracile / German: Zierliche Rohrennase / Spanish: Ratonero narizudo gracil Other common names: Delicate Tube-nosed Bat, Slender Tube-nosed Bat, Taiwanese Little Tube-nosed Bat Taxonomy. Murina gracilis Kuo Haochih et al., 2009, “ Taiwan, Ilan County, Datung Township, Yuanyang Lake Nature Reserve, 1.670 m.” See M. eleryi. Monotypic. Distribution. Taiwan I. Descriptive notes. Forearm 28-5- 31- 7 mm. Fur long and silky. Dorsal pelage is dark brown, mottled with yellowish brown (hairs with black bases, yellowish brown middles, and black tips) and intermixed with shiny golden guard hairs; venter is grayish brown to grayish white (hairs with black bases and grayish brown to grayish whitetips). Dorsal pelage extends sparsely onto wings, uropatagium, thumbs, and feet. Face is sparsely haired except for long protuberant naked nostrils. Ears are short, broad, and rounded, with smoothly convex anterior margins, small notch on posterior margins, and broadly rounded tips; tragus is long and narrow and tapers toward pointed tip. Wing attaches near base of claw on first toe. Skull has domed braincase; sagittal crest is absent, and lambdoidal crest is very weak; 12 is anterior to I%; C! is shorter and narrower than P*; P? is less than one-half the basal area of P*; and M' and M* have well-developed mesostyles. Habitat. Broadleaf and mixed forests and natural or propagated conifers predominantly at elevations of 1400-2700 m. Food and Feeding. No information. Breeding. Gracile Tube-nosed Bats reportedly give birth to two young in May; lactating females have been collected from mid-May to mid-July. Activity patterns. No information. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Least Concern on The IUCN Red List. The Gracile Tube-nosed Bat does not seem to face any major threats. Bibliography. Cheng Hsichi et al. (2017), Csorba etal. (2011), Kuo Haochih, Chen Shiangfan et al. (2014), Kuo Haochih, Fang Yinping et ai. (2009), Lee Lingling & Kuo Haochih (2017b), Nguyen Truong Son et al. (2015), Soisook, Thaw Win-Naingng et al. (2017).Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Vespertilionidae, pp. 716-981 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on page 920, DOI: 10.5281/zenodo.639775
"Novel W(CO)6-Promoted C-S Bond Cleavage Reactions of dithianes. X-Ray Structure of 9,9':9.9"-Terfluorene"
No full text
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
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