24,328 research outputs found
The political role of the people's liberation army 1949-1973
Get PDFThis thesis is to study the political role of the People's Liberation Army from the approach of structure and function. The framework of the thesis consists of three major parts, first, the influence of Chinese traditional political culture on, and the formation of, the political role of the PL A; second, the influence of domestic political struggles and external military conflicts on the development of the political role of the PLA; and the third, the analysis of the transition of the PLA's political role from the structure and personnel arrangements of the CCPCC Within the above-mentioned three scopes, this thesis make a thorough discussion on the following: (1) The relationship between the structure of the PRC and the formation of the PLA's political role; (2) How has ideology influenced the army's political role; (3) What is Mao's viewpoint and his influence on the development of the army's political role; (4) What is the link between the army and the party, and how has this developed; (6) What accounts for the expansion of the PLA's political functions; (7) What is the influence of political factional struggles on the PLA's political role; (8) Is it political institution or military institution that controls the recruitment of the military elite; (9) What are the disparities between the military elite in handling international conflicts and what are their political considerations; (10) What is the Party's position in the army; (11) How have the Party’s important meetings and personnel arrangements influenced the rise and fall of the PLA's political role
The Influence of Smartphone Use on Undergraduate Students’ Self-Directed Learning
No full textAbstract
Date Presented 4/1/2017
This study explores smartphone use in undergraduate students’ self-directed learning. The factors were identified, providing an understanding of how undergraduate students could be more motivated and effective in their short-term, self-directed learning under the influence of smartphone use.
Primary Author and Speaker: Ya-chun Chang
Additional Authors and Speakers: Kuan-Chen Chen, Wen Ting Chen, Ya-syuan Cai
Contributing Authors: Chang-Chih Robin Kuo</jats:p
When Civil Structures Bump into Automation Technologies: An interview with Dr. Kuo-Chun Chang
Get PDFAutomation technologies are extensively adopted in the fields of mechanics and manufacture. Thanks to continuous progress in scientific development, automation has been used increasingly in civil structures and structural monitoring. Through the interview of the director of NCREE, Dr. Kuo-Chun Chang, we hope that readers can examine the future developments and limits of automation technology on application in the field of civil engineering
MAC protocol adaptation in cognitive radio networks
No full textThis thesis presents an adaptive MAC (AMAC) protocol for supporting MAC layer adaptation in cognitive radio networks. MAC protocol adaptation is motivated by the exibility of emerging software-de ned radios which make it feasible to dynamically adjust radio protocols and parameters in order to maintain communications quality. Dynamic changes to the MAC layer may be useful in tactical or vehicular networking scenarios, where radio node density, tra c volumes and service requirements can vary widely over time. A speci c control framework for the proposed AMAC algorithm is described based on the "CogNet" protocol stack which uses a Global Control Plane (GCP) to distribute control information between nearby radios. An AMAC prototype which switches between CSMA and TDMA is evaluated for various tra c scenarios using the NS-2 simulator. In addition, a proof-of-concept AMAC is implemented using GNUradio/USRP platforms on the ORBIT radio grid testbed. Detailed simulation and experimental results are given for both UDP and TCP tra c with di erent usage scenarios and application models. The results show that AMAC can provide improved performance relative to a conventional static system and can be implemented with reasonable control protocol overhead and latency.M.S.Includes bibliographical referencesby Kuo-Chun Huan
Cadmium-induced ammonium ion accumulation of rice seedlings at high temperature is mediated through abscisic acid
No full textModeling of post flame oxidation process of unburned hydrocarbons in spark ignition engines
Get PDFThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1997.Includes bibliographical references (p. 92-96).by Kuo-Chun Wu.Ph.D
The Architect of Taiwan's Economic Miracle: Evolutionary Economics of Li Kuo-Ting
No full textTaiwan has been referred to by the World Bank as one of the East Asia's “economic miracles”. Many quantitative models on Taiwan's economic growth have been conducted by neo-classical mainstream economists. However, none of them investigates in detail the thinking of those policy-makers who work behind the economic success of Taiwan. Li Kuo-Ting is generally regarded as the architect of Taiwan's economic “miracle”. In this paper, an evolutionary perspective has been used to understand the economic management of Li Kuo-Ting in particular and the learning government in Taiwan in general. It will be argued that a policy change is a matter of learning, experimenting, and a process of trial and error, involving subjective aspects such as the policy-makers' perception, vision and experiences, and objective factors such as environmental, geographical or international constraints. Furthermore, Taiwan has been able to succeed because its policy-makers are willing to learn and unlearn. Though the right policy has not always been adopted, Taiwan's policy-makers are willing to experiment with a new policy in a pragmatic way. Policies that did not work were either modified or abandoned. Policies that did work were adopted. This paper concludes that Taiwan's economic “miracle” has been the result of a long-term evolutionary process of entrepreneurial vision by the government, careful policy experimentation and market selection.Li Kuo-Ting, Taiwan, evolutionary economics, economic development, government policy,
Supplementary_Table_and_Figure-R2_EDITS – Supplemental material for Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer
No full textSupplemental material, Supplementary_Table_and_Figure-R2_EDITS for Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer by Chia-Chen Chang, Kuo-Wei Bi, Hung-Jen Lin, Yuan-Chih Su, Wen-Ling Wang, Chen-Yuan Lin, Chun-Fu Ting, Mao-Feng Sun and Sheng-Teng Huang in Integrative Cancer Therapies</p
Investigation of Anticancer Mechanism of a Flavonoid Derivative in Human Androgen-Independent Prostate Cancer Cells
No full text前列腺癌一直是西方國家高罹患率及高死亡率的癌症之一，而隨著生活習慣及飲食的西化，前列腺癌的罹患率及死亡率也在亞洲地區快速的攀升。造成前列腺癌高死亡率的主要原因來自於癌症的轉移及惡化，但目前並沒有有效治療的藥物，極需要相關研究的投入。本次研究之化合物WJ9708012 (6-(3-Hydroxy-3-methylbutyl)-2’-(7-hydroxy-3,7-dimethyloctyl)-3’,4’,5,7-Tetramethoxy
-flavanone) 為類黃酮類結構，與一般類黃酮類化合物不同，其不具有強效的抗氧化能力，但對於人類賀爾蒙抗性前列腺癌細胞PC-3及DU-145，則展現抑制細胞生長及促進細胞凋亡之能力。於抑制細胞生長功能上，WJ9708012藉由抑制mTOR相關訊息傳遞路徑，使cyclin D1等G1細胞週期調控之重要分子表現量降低，造成G1細胞週期停滯現象。使用西方點墨法觀察發現，WJ9708012造成p-mTORser2448、p-P70S6KThr389及p-4E-BP1Thr37/46位置的磷酸化現象明顯減少，使eIF4E調控的7-methylguanosine 5’-triphosphate (m7GTP) cap-dependent translation無法進行，下游cyclin D1等G1細胞週期相關蛋白在mRNA沒有明顯減少的情況下蛋白表現量皆大幅降低，使細胞無法順利通過G1細胞週期，產生停滯生長現象。此現象可藉由給予胎牛血清使mTOR相關訊息傳遞路徑活化的方式降低，間接證明抑制mTOR相關訊息傳遞在此化合物抑制細胞生長之功能中扮演重要角色。在引起細胞凋亡方面，短時間處理WJ9708012可產生一個由細胞外進入胞內的鈣離子流，造成胞內鈣離子濃度迅速上升並活化鈣離子相關訊息分子，如：μ-calpain、PKC-α及calmodulin，使細胞內粒線體及內質網兩個調控鈣離子之重要胞器產生壓力或傷害等影響。粒線體部分，WJ9708012造成粒線體損傷，使膜電位流失及下游內生性細胞凋亡訊息途徑啟動。以西方點墨法觀察，可發現化合物造成粒線體凋亡因子釋出、caspase-9、-3、-7活化及晚期Bcl-2家族蛋白表現量改變及斷裂現象。另外，化合物也會造成細胞內能量恆定失調，使在此扮演細胞保護功能之AMPK蛋白活化，調控下游訊息分子。於內質網部分，則可觀察到內質網壓力產生，使GRP78、GADD153及Caspase12表現量增加或斷裂活化的現象。WJ9708012引起的粒線體損傷和內質網壓力在密切的訊息傳遞後，會造成細胞凋亡途徑的啟動。使用流式細胞儀可觀察到subG1細胞增加和具有PI-Annexin X雙重螢光訊號細胞增加的現象。此外，使用TUNEL assay亦可觀察到具有DNA斷點的螢光訊號之細胞增加情形。總體而言，WJ9708012引起人類賀爾蒙抗性前列腺癌細胞PC-3細胞G1細胞週期停滯及細胞凋亡反應，主要是藉由抑制mTOR相關訊息傳遞路徑及引起鈣離子流入細胞質，影響相關訊息傳遞分子之活性，並造成粒線體及內質網損傷，而啟動細胞凋亡途徑來達成。Prostate cancer is one of the leading causes of cancer death among men in the United States and Western Europe. Following the transition of lifestyle to Western type, the mortality of prostate cancer is rapidly increased in Asian countries. Most prostate cancer-related deaths are due to advanced disease and, until recently, the hormone therapy was the only well-acceptable treatment approved for advanced prostate cancer. However, many patients were resistant to hormonal therapies after two to three years of treatment and no effective therapy currently exists for advanced prostate cancers that are resistant to hormonal therapy. In this thesis, we reported that a methoxyflavanone – WJ9708012 (6-(3-Hydroxy-3-methylbutyl)-2’-(7-hydroxy-3,7-dimethyloctyl)-3’,4’,5,7-
Tetramethoxyflavanone) inhibited growth and produced apoptosis of human hormone-resistant prostate cancer PC-3 and DU-145 cells. WJ9708012 inhibited cell proliferation and induced G1-phase cell-cycle arrest. By using Western blotting analysis, we found that WJ9708012 induced a rapid and time-dependent decrease of phosphorylation level of mTORSer2448, P70S6KThr389 and 4E-BP1Thr37/Thr46, which would suppress 7-methylguanosine 5’-triphosphate (m7GTP) cap-dependent translation through inhibiting eIF4E release from the translational repressor 4E-BP1 and down-regulating the expression of cyclin D1. The stimulation of mTOR-related signaling pathway by fetal bovine serum could rescue the anti-proliferative effect of WJ9708012, indicating an important role of mTOR-related signaling pathway to WJ9708012 action. The treatment of PC-3 prostate cancer cells with WJ9708012 also induced a prompt calcium influx from the extracellular space. The increase in [Ca2+]i was associated with the activation of calcium-related signaling molecules, including calpain, PKC-α and calmodulin. Subsequently, these events caused mitochondria damage and resulted in the induction of cell apoptosis. By using Western blotting analysis, we found that WJ9708012 induced a mitochondria-regulated apoptosis, which involves the release of cytochrome c, activation of caspase-9, -3, and -7 and alteration of protein expression of Bcl-2 family members. Moreover, because of the damage of mitochondria function, WJ9708012 also caused the activation of AMPK, which served as a protective signal and regulated the downstream signal molecules. The endoplasmic reticulum (ER) stress was also induced by WJ9708012, which is associated with the cleavage of pro-caspase12 and the up-regulation of protein levels of GADD153 and GRP-78. A crosstalk between ER stress and mitochondrial insult was observed, leading to the apoptosis events in PC-3 cells. The apoptosis triggered by WJ9708012 in PC-3 cells was assessed using annexin V/ PI labeling and the TUNEL assay. Taken together, the data suggest that WJ9708012 causes a G1-phase cell cycle arrest by inhibiting mTOR-related pathways and induces the cell death through the activation of calcium influx from extracellular space matrix followed by ER stress and mitochondria damage, which would trigger the intrinsic apoptotic pathways
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