18 research outputs found
Molecular cloning of phaCAL gene for expression in Bacillus for the production of PHA and PHA Production studies
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
A FACE & EYE DETECTION MODEL FOR DRIVING AN AUTOMOBILE
No full textThis paper proposes an inexpensive vision-based system to exactly identify Eyes Off target (EOR). The device has three primary components: 1) robust facial feature monitoring 2) mind pose and gaze estimation and 3) 3-D geometric reasoning to recognize EOR. Within the video stream from the camera put on the controls column, our physiques tracks facial features within the driver’s face. While using the supervised landmarks plus a 3-D face model, the device computes mind pose and gaze direction. Distracted driving is probably the primary causes of vehicle collisions within the United States. States. Passively monitoring a driver’s activities comprises the building blocks from the automobile safety system that could potentially reduce the quantity of accidents by estimating the driver’s focus of attention. Your brain pose estimation formula is robust to no rigid face deformations due to modifications in expressions. Finally, employing a 3-D geometric analysis, the device reliably detects EOR. The recommended system does not need any driver-dependent calibration or manual initialization and works instantly (25 FPS), during the day and night. Our physiques accomplished above 90% EOR precision for individuals examined situations. To validate the performance in the system in the real vehicle atmosphere, we transported out a comprehensive experimental evaluation under all types illumination conditions, facial expressions, and individuals
Design, synthesis and pharmacological evaluation of novel fused pyrimidine analogues as anticancer agents.
No full textDoctoral Degree. University of KwaZulu-Natal, Durban.Cancer is a multifaceted disease considered as the most serious health burden all over the world. Due
to existing of limited anticancer drugs and detrimental side effects, the anticancer research has been
challenging. An investigation on identifying novel potential drugs is highly required to treat this serious
abnormal cell growth. Advanced potential anticancer drug entrants are crucially required to combat the
drawbacks linked with current drugs or line of therapies. Extensive investigations are being carried out
on synthetic manipulations of heterocyclic aromatic compounds (purines) for developing efficient and
potent anticancer drugs. Besides, these manipulations also offer effective leads for further optimization.
Therefore, this project is an effort in detecting a novel and potent anticancer leads based on bioisostere
of purines called pyrazolopyrimidines.
In this research project we have performed an comprehensive literature survey of structural isomers of
pyrazolopyrimidines (pyrazolo[1,5-a]pyrimidine and pyrazolo[4,3-d]pyrimidine) for their synthetic
approaches and biological activities with special emphasis on structure-activity relationship (SAR)
studies. These SAR studies prompted us to implement the observed studies on one of the structural
isomer of pyrazolopyrimidine called pyrazolo[3,4-d]pyrimidine. And further, we have synthesized
some novel series of pyrazolo[3,4-d]pyrimidine derivatives with various substituents at C-4 and C-6
positions of the scaffold. A total 71 compounds comprising of phenethyl and pentane hybrids (7-43,
Chapter 4), benzoyl hybrids (5a-5h, 6a-6d and 7a-7c, Chapter 5) and lastly phenylcarbamoyl acetamide
hybrids (9a-9s, Chapter 6) have been synthesized by molecular hybridization approach as outlined in
schemes of respective chapters. The completion of reaction and the purity of novel synthesized
compounds were confirmed by chromatographic analysis. All the newly synthesized compounds
displayed acceptable analysis for their anticipated structures, which were established based on
physicochemical and spectral data (IR, 1
H NMR, 13C NMR and HRMS).
All synthesized compounds were primarily evaluated for their in vitro anticancer activities at
Laboratory of Growth Regulators, Centre of the Region Hana for Biotechnological and Agricultural
Research, Palacky University & Institute of Experimental Botany ASCR, Slechtitelu 27, 78371
Olomouc, Czech Republic.
From the systematic analysis of anticancer activity, results obtained following key observations were
made.
i. Structural isomers of fused pyrimidines have been looked upon for molecular changes in
emerging drug like candidates. Pyrazolopyrimidine is a bioisostere of purines has acquired
considerable importance due to its diverse, facile and general synthetic methodologies with
great medicinal importance. Several analogs of this scaffold have emerged as a promising
leads in the design of some novel pharmacologically active compounds with enhanced
iii
metabolic, pharmacokinetic and pharmacological profiles, representing that there is plenty
scope for considering pyrazolopyrimidine as a structural framework for evolving effective
leads.
ii. Chapter 4: From the 37 novel phenethyl and alkyl pentane pyrazolo[3,4-d]pyrimidine
derivatives synthesized and evaluated for CDK2/Cyclin E, Abl kinase inhibitory activity
and anti-proliferative activity against K-562 (chronic myelogeneous leukemia) and MCF7 (breast adenocarcinoma) cell lines. From the tested results, compounds 11 (CDK: IC50 =
5.1 µM; Abl: ˃12.5 µM), 8 (CDK: IC50 = 7.8 µM; Abl: ˃25 µM) and 36 (CDK: IC50 = 8.8
µM; Abl: >25 µM) exhibited significant inhibitory activity. Further from this series, most
of the synthesized compounds indicated prominent anti-proliferative effects with IC50 value
ranging from 19.2 µM to 27.4 µM. Incorporation of monosubstituted phenyl groups at C-4
of the pyrazolo[3,4-d]pyrimidine nucleus had favored for most prominent anticancer
activity.
iii. Chapter 5: Among the 15 novel benzoyl hybrids synthesized and evaluated, compounds 5a
and 6c displayed (CDK2: IC50 = 8.8 µM, 6.8 µM) commendable inhibitory activity and
notable anti-proliferative activity ranging from 18.9 µM to 89.3 µM). Presence of
heteroatom containing bicyclic moieties at C-4 of the nucleus enhanced both inhibitory and
anti-proliferative activity.
iv. Chapter 6: Of the 19 novel phenylcarbamoyl acetamide hybrids synthesized and tested,
compounds 9a, 9c, 9g, 9m and 9p showed moderate enzymatic inhibitory activity with an
IC50 value ˃12.5 µM against both CDK2 and Abl kinases while, remaining compounds of
this series could not generate IC50 values due to solubility limit (IC50 = ˃25 µM to ˃100
µM).Professor Neil Koorbanally was acknowledged by the author as his previous supervisor
ChemInform Abstract: Asymmetric Michael Addition of Ketones to Nitroolefins: Pyrrolidinyl‐oxazole‐carboxamides as New Efficient Organocatalysts.
No full textAsymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts
No full textSex trafficking of girls and women : Evidence from Anantapur district, Andhra Pradesh
No full textA crucial gap in the trafficking literature from India is the dearth of primary data and micro studies that could be used for vulnerability mapping of the source areas and addressing the identified risk factors. The present paper is a small attempt to contribute to plugging the gap in the context of Andhra Pradesh, identified as a hot spot in the trafficking literature. This paper is based on case studies of 78 women who had been trafficked from their places of origin in Anantapur district in Andhra Pradesh to metropolitan cities across India and who have since returned to their homes. The paper attempted to identify the individual and family circumstances that contribute to the causes of trafficking, to highlight in particular the gendered vulnerabilities that set these women up for trafficking, and to capture the process of the trafficking experience. The findings of the study are located in the dynamic interplay of the social structural context and specificities of the district that contribute to causes of trafficking and the individual circumstances and agency of the women. The case studies reported in this paper are a pointer to the compelling urgency of interventions that will go beyond the forced / voluntary divide in trafficking and sex work.Andhra Pradesh, India, trafficking
Kapitalerhaltung bei Anwendung der erfolgsneutralen Stichtagskursmethode zur Währungsumrechnung
No full textDifferent methods for the translation of financial statements of foreign subsidiaries result in different profit contributions in the consolidated financial statements and accordingly to different amounts of capital maintained as measured in the group's reporting currency. The translation methods imply assumptions about the validity of macro-economic equilibria such as the Purchasing Power Parity or the Fisher Effect. A model contrasting central and local capital maintenance is developed under the assumption that the International Fisher Effect is valid. The consumption of capital is analyzed when the closing rate method is used with exchange differences offset against capital. This method is prevalent under the application of the functional method according to IAS 21 and SFAS 52. An empirical analysis shows that the impact on the consolidated financial statements of the DAX 30 companies for fiscal year 2004 is significant. With respect to this evidence accounting measures may be misleading for economic decisions or judgements. --Foreign currency translation,capital maintenance,functional method,closing rate method,International Fisher Effect,Purchasing Power Parity
