8,388 research outputs found
Replication Data for: Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics
No full textCancer is a fatal genetic disease with varying complexities, including immune evasion, treatment resistance and recurrence, and optimized treatment is needed for a proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity of cancer development, which is ultimately linked to its genetic machinery. Importantly, patients with the same type of cancer respond differently to available cancer treatments, indicating the need for patient-specific treatment options. Thus, in-depth genomic studies of patients’ tumors are needed to fully understand the determinants of cancer initiation and progression for effective targeted therapy. Precision oncology has evolved as a form of cancer therapy focused on genetic profiling of tumors to identify molecular alterations involved in cancer manifestation for tailored individualized treatment of the disease. There have been great developments in the formulation and production of anticancer agents in recent years, mainly owing to advances in molecular technologies enabling precise targeting of oncogenic pathways involved in disease progression. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of advancements in the tools and techniques associated with the process to assess its scope and importance in realizing the intended goals
Constitutionalizing E-mail Privacy by Informational Access
No full textKumar, Manish. (2007). Constitutionalizing E-mail Privacy by Informational Access. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/155630
Improving the performance of sparse cholesky factorization with fine grain synchronization
No full textThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.Includes bibliographical references (leaves 61-62).by Manish Kumar Tuteja.M.S
Replication Data for: Precision Medicine Approach to Signal Based Targeted Therapy of Cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Thus, precision oncology that relies on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article intends to comprehensively elucidate the foundations and frontiers of precision oncology in the context of recent advances in the field of cancer genomics and single-cell technology for efficient cancer treatment
Precision Medicine Approach to Signal Based Targeted Therapy of Cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Thus, precision oncology that relies on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article intends to comprehensively elucidate the foundations and frontiers of precision oncology in the context of recent advances in the field of cancer genomics and single-cell technology for efficient cancer treatment
Replication Data for: Precision Oncology bringing a paradigm shift in the treatment of cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Precision oncology relying on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article tries to comprehensively elucidate the foundations and frontiers of precision oncology in the context of single-cell technology for efficient cancer treatment
Replication Data for: Precision Oncology, Cell Signaling and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics
No full textIn recent decades, there has been a deluge in the large-scale production of anticancer agents, primarily due to advances in genomic technologies enabling precise targeting of oncogenic pathways involved in disease progression. This initiated a paradigm shift in cancer research and therapeutics based on the ability to study molecular changes throughout the genome. It provided a unique opportunity in the field of translational cancer research and have led to the concept of precision medicine in cancer therapy, raising hopes of developing better diagnostic and therapeutic means for the management of cancer. The purpose of this article is to briefly review the tools and techniques involved in precision oncology research and their applications in the field of cancer treatment
The role of part structure in the perceptual localization of a shape
No full textThe process of object localization may be accomplished with respect to a particularreference location, such as the center of gravity, COG (eg Vishwanath and Kowler, 2003 VisionResearch 43 1637-1653). Here, we investigated how part structure affects an object's referencelocation. The reference location was evaluated with a measure of the illusory displacement of an internal target element embedded within a larger object (Morgan et al, 1990 Vision Research 30 1793-1810). To examine whether the reference location is different for shapes with part structure, two shapes were tested: circle (small and large; no part structure) and bell (shape with two parts, one larger than the other). Results were examined with respect to two predictions: either the location of an object is based on its shape as a whole, disregarding part structure (ie a single, overall COG), or the parts are processed separately (different COGs).With the circles, the results showed a systematic illusory displacement of the internal target toward the COG. With the bell, the illusion was significantly weaker than with both circles--even though the main part of the bell had the same size as the small circle, and its horizontal axis had the same extent as the large circle. Moreover, the distance judgments for the bell were consistent with a (weaker) reference point being located at the COG of the larger part, rather than at the COG of the entire bell. These results show that the part structure of a shape plays a role in the representation of its location, and that for complex shapes the perceived location of an embedded element depends more on the parts within which it is embedded, rather than on the whole shape.Supported by the Air Force Office of Scientific Research, Grant AF 49620- 02-1-0112, Life Sciences Directorate to Eileen Kowler, and by NSF, Grant BCS-0216944 to Manish Singh.AF 29620-02-1-0112; to Eileen KowlerNSF BCS-0216944; to Manish SinghDenisova, Kristina, Manish Singh, Eileen Kowler, 2006. The definitive, peer-reviewed and edited version of this article is published in Perception, 35, 1073-1087, DOI:10.1068/p5518
sj-docx-1-pie-10.1177_09544089221109739 - Supplemental material for Influence of high-intensity horizontal mould vibration on the density, grain refinement and mechanical characteristics of a die cast aluminium alloy (LM21)
No full textSupplemental material, sj-docx-1-pie-10.1177_09544089221109739 for Influence of high-intensity horizontal mould vibration on the density, grain refinement and mechanical characteristics of a die cast aluminium alloy (LM21) by Siddharth Yadav, Santosh Kumar, Satya Prakash Tewari, Subhash Chandra Ram, Rabindra Prasad, Nitesh Kumar Sinha, Manish Deo and Jayant Kumar Singh in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
Supplementary_Tables – Supplemental material for <i>E2F1</i> genetic variants and risk of cervical cancer in Indian women
No full textSupplemental material, Supplementary_Tables for E2F1 genetic variants and risk of cervical cancer in Indian women by Sanjay Singh, Manish Gupta, Rajeev Kumar Seam and Harish Changotra in The International Journal of Biological Markers</p
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