1,968 research outputs found
Limitations and future applications of quantum cryptography Advances in information security, privacy, and ethics (AISPE) book series./ Neeraj Kumar, Alka Agrawal, Brijesh K. Chaurasia, Raees Ahmad Khan.
No full text"Premier Reference Source"--Taken from front coverIncludes bibliographical references and index."This book is for security experts as well as for IoT developers to help them understand the concepts related to quantum cryptography and classical cryptography and providing a direction to security professionals and IoT solution developers toward using approaches of Quantum Cryptography as available computational power increases"--VLSI architecture of substitution box / Abhishek Kumar, Suman Tripathi -- Fundamentals of quantum computing, quantum supremacy and quantum machine learning / Kamaljit Lakhtaria, Vrunda Gadesha -- Quantum security for IoT to secure healthcare applications and it's data / Binod Kumar, Sheetal Prasad -- Data hiding in color image using steganography and cryptography to support message privacy / Sabyasachi Pramanik, Ramkrishna Ghosh, Sneh Kalra, Jayeeta Majumder, Digvijay Pandey, Souvik Pal -- Quantum computing : concept, applications and need of law for its enforcement / Neeraj Kumar, Alka Agrawal -- Quantum algorithms with applications to cryptography : quantum algorithms / Renata Wong, Amandeep Bhatia -- Implications on quantum cryptography : cryptography / Varsha Sahni, Neeraj Kumar, Sujatha Krishnamoorthy -- A contemporary study on quantum-computing security mechanisms in 5G networks / Rydhm Beri -- Define security and privacy using quantum internet / Nilay Mistry, Ankit Dholakiya, Jay Prajapati -- Quantum and visual crypto biometric based secured authentication system transactions, server and locker system in cloud / Nandini C., Jahnavi S. -- The role of quantum computing in software forensics & digital evidence : issues and challenges / Sandeep Sharma, Mazhar Khaliq -- Recent progress in quantum machine learning / Amandeep Bhatia, Renata Wong -- Advances of quantum machine learning / Bhanu Chander -- Image processing using quantum computing : a review / Bably Dolly, Deepa Raj -- Quantum cryptography for securing IoT based healthcare system / Anand Sharma -- Function optimization using IBM Q / Soumyajit Goswami.1 online resource (xxvii, 305 pages)
Security on Cloud using High Level Encryption Techniques
No full textIn today's life security of data is most important for everyone so it's very important that how secure data at the run time. With cloud computing platform it is very easy to transfer data between users and store any amount of data on cloud so it is easy to use anytime anywhere. To provide security on cloud it's very difficult because many issues are happened during provide security so with the help of this paper it's easy to provide storage security of data on cloud by physical hardware and virtual encryption process and security services on gateway to improve safe transaction of data Brijesh Kumar | Amrita Saraswat "Security on Cloud using High Level Encryption Techniques" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: https://www.ijtsrd.com/papers/ijtsrd4712.pd
BH3-only protein BIM: An emerging target in chemotherapy
No full text10.1016/j.ejcb.2017.09.002EUROPEAN JOURNAL OF CELL BIOLOGY968728-73
The role of poly (ADP-ribose) polymerase-1 in the celluar response to several marine-derived compounds:
No full textPARP-1 is a multi-functional protein that is involved in many DNA-dependent genomic processes under normal and pathophysiological conditions. It is well characterized as a DNA damage detector and responds by catalytic production and attachment of polymers of ADP-ribose (PAR) to nuclear protein targets, facilitating the chromatin changes that are a prerequisite to DNA repair. In this study, we tested whether PARP-1 is involved in the cellular response to Yondelis®, Zalypsis®, PSL1, and PSL2, novel chemotherapeutic agents with putative DNA damage- and transcription-targeted activities. We observed a dose-dependent activation of PARP-1 catalytic activity following treatment with all four compounds, while PARP-1 protein levels remained unchanged. Interestingly, cells derived from PARP-1 null mice were significantly sensitized to the agents, yet, with respect to Yondelis®, only moderate DNA damage was observed which was repaired with equal efficiency by both PARP-1 wildtype and PARP-1 null cells. While the mechanism of sensitization is unclear, it is of interest to determine whether inhibition of PARP in human cells could sensitize cells to the four agents. Initial in vivo experiments testing this prediction using MX-1 breast carcinoma xenografts treated with Yondelis® alone or in combination with the PARP-1 inhibitor DIQ, demonstrate an additive effect between these two compounds with regard to tumor volume inhibition and tumor growth delay. However, corresponding in vitro experiments failed to corroborate this observation. The effects of PARP-1 on the transcription of genes impacting drug sensitivity, as well as the cyto-protective role of PARP-1 independent of its catalytic function are of interest to direct future efforts to clarify the mechanism of PARP-1-mediated sensitivity to the four agents. Taken together, these data suggest that PARP-1 plays an important role in the protection of cells to Yondelis®, Zalypsis®, PSL1, and PSL2, and suggest that PARP-1 status may determine the sensitivity or resistance of cells treated with these agents.M.S.Includes bibliographical references (p. 45-53)by Brijesh B. Pate
Blood Oxygenation Quantification In The Human Fetal Brain Using Susceptibility Weighted Imaging And Mapping
No full textBLOOD OXYGENATION QUANTIFICATION IN THE HUMAN FETAL BRAIN USING SUSCEPTIBILITY WEIGHTED IMAGING AND MAPPING
by
BRIJESH KUMAR YADAV
May 2018
Advisor: Dr. E. Mark Haacke
Major: Biomedical Engineering with Dual title in Biomedical Imaging
Degree: Doctor of Philosophy
Oxygen is a source of life for us and our dependency upon it begins in the fetal stage. Normal growth and development of the fetus rely on the adequate supply of oxygen. Therefore, placenta undergoes morphological and functional changes throughout pregnancy to accommodate the oxidative needs of the growing fetus. However, obstruction to this supply might lead to fetal hypoxia or manifest intrauterine growth restriction (IUGR) which in turn, causes physical and neurological deficits. A combination of fetal assessment tests, including ultrasound-based blood flow indices from feto-placental circulation are used today for identifying hypoxic fetuses antenatally. Despite this, only about 15% to 25% of those cases are detected. Moreover, there are no non-invasive methods clinically present for measuring fetal brain oxygenation across second and third trimester. Because of this, normal cerebral blood oxygenation levels of the growing human fetus are not known.
In this work, therefore, we aimed to fill this knowledge gap by evaluating the fetal brain oxygenation using a magnetic resonance imaging (MRI) based technique called as susceptibility weighted imaging (SWI). Using the intravascular phase information of the superior sagittal sinus (SSS), venous oxygenation in the fetal brain was measured and the baseline fetal oxygenation was established. We also presented a multi-modality approach to study the significance of correlating the brain perfusion using measured Ultrasound (US) with cerebral oxygenation measured using SWI in the healthy human fetuses. Finally, we explored the feasibility of applying a model and orientation independent method named as quantitative susceptibility mapping (QSM) for more robust fetal blood oximetry. These efforts will in-part have helped in paving the way for a non-invasive technique for assessing fetal health and could have significant impact in early detection of hypoxic fetuses in high-risk pregnancies
Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
No full text10.3390/ijms21051645INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES21
Therapeutic Advances in Alzheimer’s Disease: Integrating Natural, Semi-Synthetic, and Synthetic Drug Strategies
No full textAbstract: Alzheimer’s disease (AD) is a neurodegenerative disorder associated with age, marked by progressive memory loss linked to the decline of cholinergic neurons, accumulation of amyloid plaques, and the presence of Neurofibrillary Tangles (NFTs). Neuropil threads in the brain contribute to amyloidosis and dementia. Despite extensive research, AD’s etiology remains unclear, and currently, no promising therapy exists. This review examines the role of natural, semi-synthetic, and synthetic drugs in AD treatment. Natural drugs demonstrate safety and efficacy with minimal adverse effects, while most agents, whether natural or synthetic, target multiple steps or directly counteract amyloidogenesis, tau protein pathology, oxidative stress, NMDA receptor activity, inflammation, acetylcholine (AChE) function, or α, β, γ secretase activity. In pursuit of improved treatment outcomes, we explore the effectiveness and challenges of various therapeutic interventions. Our hypothesis underscores the importance of an integrated approach combining these drug types for tailored symptom relief, suggesting combined therapies may offer greater therapeutic benefits compared to single-drug approaches. The drugs discussed show potential in regulating AD, thereby presenting viable options for its management. However, to obtain more favorable results, additional studies are needed by combining these drugs
Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy
No full text10.1016/j.mce.2017.02.018MOLECULAR AND CELLULAR ENDOCRINOLOGY458C160-16
Decreased autophagy and fuel switching occur in a senescent hepatic cell model system
No full text10.18632/aging.103740AGING-US121413958-1397
Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis
No full text10.1210/er.2016-1103ENDOCRINE REVIEWS38169-10
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