74 research outputs found
Serum magnesium levels and its correlation with level of control in patients with asthma: A hospital-based, cross-sectional, prospective study
No full textEnhanced auditory evoked potentials in musicians: A review of recent findings
No full textAbstractAuditory evoked potentials serve as an objective mode for assessment to check the functioning of the auditory system and neuroplasticity. Literature has reported enhanced electrophysiological responses in musicians, which shows neuroplasticity in musicians. Various databases including PubMed, Google, Google Scholar and Medline were searched for references related to auditory evoked potentials in musicians from 1994 till date. Different auditory evoked potentials in musicians have been summarized in the present article. The findings of various studies may support as evidences for music-induced neuroplasticity which can be used for the treatment of various clinical disorders. The search results showed enhanced auditory evoked potentials in musicians compared to non-musicians from brainstem to cortical levels. Also, the present review showed enhanced attentive and pre-attentive skills in musicians compared to non-musicians
Pre-attentive auditory discrimination skill in Indian classical vocal musicians and non-musicians
No full textAbstractObjectiveTo test for pre-attentive auditory discrimination skills in Indian classical vocal musicians and non-musicians.DesignMismatch negativity (MMN) was recorded to test for pre-attentive auditory discrimination skills with a pair of stimuli of /1000 Hz/ and /1100 Hz/, with /1000 Hz/ as the frequent stimulus and /1100 Hz/ as the infrequent stimulus. Onset, offset and peak latencies were the considered latency parameters, whereas peak amplitude and area under the curve were considered for amplitude analysis.Study sampleExactly 50 participants, out of which the experimental group had 25 adult Indian classical vocal musicians and 25 age-matched non-musicians served as the control group, were included in the study. Experimental group participants had a minimum professional music experience in Indian classic vocal music of 10 years. However, control group participants did not have any formal training in music.ResultsDescriptive statistics showed better waveform morphology in the experimental group as compared to the control. MANOVA showed significantly better onset latency, peak amplitude and area under the curve in the experimental group but no significant difference in the offset and peak latencies between the two groups.ConclusionThe present study probably points towards the enhancement of pre-attentive auditory discrimination skills in Indian classical vocal musicians compared to non-musicians. It indicates that Indian classical musical training enhances pre-attentive auditory discrimination skills in musicians, leading to higher peak amplitude and a greater area under the curve compared to non-musicians
Neuroprotective role of Alpha Lipoic Acid on Oxidative Stress Induced by acrylamide in Rat Brain
Get PDFOur study is an effort to evaluate the neuroprotective effect of ALA by studying the biochemical parameter such as enzymatic and non enzymatic antioxidant, GSH, LPO and total lipid content as will as histopatholocial Alteration observed in case of Acrylamide induced rat brain.
The out come of our investigation is summarized as below
The level of SGPT, SGOT and LDH is increased in ACR induced rat when as the levels are reduced in ALA treated rats enzyme antioxidant (SOD, GPX) and non antioxidant (GSH, GR) was found to be declined in case of acrylamide induced rats. ALA treatment challenging with acrylamide brought back to normal level by protecting the cell membrane intergrity.
An elevation in the level of the MDA was observed which is an indicator of membrane lipid peroxidation in ACR induced rat and it was reversed by the supplement of the ALA.
Histopatholocigal report Shows neuronal cell degeneration in ACR induced and the cell recovery is observed on ALA treatment.
Thus from our study we came to concluded that OS imposed by acrylamide resulted pronounced neurotoxicity in rats. In the contrast, ALA treated rat showed normalization of the oxidative parameters. This Snapshot throws light on the fact that the ALA might be beneficial in the OS medicated neurotoxicity provoked byacrylamide. Further comprehensive studies in the neurotoxicity of acrylamide are under way
Comparison of Pre-Attentive Auditory Discrimination at Gross and Fine Difference between Auditory Stimuli
No full textAbstract
Introduction Mismatch Negativity is a negative component of the event-related potential (ERP) elicited by any discriminable changes in auditory stimulation.
Objective The present study aimed to assess pre-attentive auditory discrimination skill with fine and gross difference between auditory stimuli.
Method Seventeen normal hearing individual participated in the study. To assess pre-attentive auditory discrimination skill with fine difference between auditory stimuli, we recorded mismatch negativity (MMN) with pair of stimuli (pure tones), using /1000 Hz/ and /1010 Hz/ with /1000 Hz/ as frequent stimulus and /1010 Hz/ as infrequent stimulus. Similarly, we used /1000 Hz/ and /1100 Hz/ with /1000 Hz/ as frequent stimulus and /1100 Hz/ as infrequent stimulus to assess pre-attentive auditory discrimination skill with gross difference between auditory stimuli. The study included 17 subjects with informed consent. We analyzed MMN for onset latency, offset latency, peak latency, peak amplitude, and area under the curve parameters.
Result Results revealed that MMN was present only in 64% of the individuals in both conditions. Further Multivariate Analysis of Variance (MANOVA) showed no significant difference in all measures of MMN (onset latency, offset latency, peak latency, peak amplitude, and area under the curve) in both conditions.
Conclusion The present study showed similar pre-attentive skills for both conditions: fine (1000 Hz and 1010 Hz) and gross (1000 Hz and 1100 Hz) difference in auditory stimuli at a higher level (endogenous) of the auditory system
Prevalence of mismatch negativity with tonal stimuli in normal-hearing individuals
No full textAbstract Electrophysiological measures are one of the objective modes of assessment to check the integrity of the auditory function. The endogenous potentials like mismatch negativity (MMN) are responses which are due to internal events such as cognition or perception. In clinical practice and researches it was observed that MMN not present in all normal hearing individual. So, there is a need to study prevalence of MMN in normal population, which helps the researchers and clinicians in interpreting clinical findings. 50 participants recruited in the age range of 18–25 years. MMN was recorded with pair of stimuli. The pair was having /1000Hz/ and /1100Hz/ with /1000Hz/ as frequent stimulus and /1100Hz/ as the infrequent stimulus. Out of 50 normal hearing subjects, MMN was present only in 33 normal hearing subjects (66%). So clinician should be cautious during interpretation of clinical findings using MMN in abnormal population
Auditory Temporal Resolution in Individuals with Diabetes Mellitus Type 2
No full textAbstract
Introduction “Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action” (American Diabetes Association). Previous literature has reported connection between diabetes mellitus and hearing impairment. There is a dearth of literature on auditory temporal resolution ability in individuals with diabetes mellitus type 2.
Objective The main objective of the present study was to assess auditory temporal resolution ability through GDT (Gap Detection Threshold) in individuals with diabetes mellitus type 2 with high frequency hearing loss.
Methods Fifteen subjects with diabetes mellitus type 2 with high frequency hearing loss in the age range of 30 to 40 years participated in the study as the experimental group. Fifteen age-matched non-diabetic individuals with normal hearing served as the control group. We administered the Gap Detection Threshold (GDT) test to all participants to assess their temporal resolution ability.
Result We used the independent t-test to compare between groups. Results showed that the diabetic group (experimental) performed significantly poorer compared with the non-diabetic group (control).
Conclusion It is possible to conclude that widening of auditory filters and changes in the central auditory nervous system contributed to poorer performance for temporal resolution task (Gap Detection Threshold) in individuals with diabetes mellitus type 2. Findings of the present study revealed the deteriorating effect of diabetes mellitus type 2 at the central auditory processing level
ChemInform Abstract: Microwave Assisted One Pot 1,3‐Dipolar Cycloaddition Reactions of Novel Dihydropyran Derived Nitrone.
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