3 research outputs found
Effect of Sesbania grandiflora Linn leaf extracts on diuresis in wistar rats
No full textBackground: This study was designed to evaluate the effect of sesbania grandiflora linn leaf extracts on diuretic activity in wistar rats.Methods: Healthy male wistar albino rats divided into 9 groups and weighing 150-200gm.diuretic activity was expressed by Natriuretic activity, saluretic activity, carbonic anhydrase inhibition, Diuretic index or Diuretic action, saluretic index, Natriuretic index. Animalgroups are divided into: group1 treated as control, 2and 3 treated as standards, group 4, 5 and 6 treated with aqueous leaf extract of Sesbania grandiflora Linn. in different doses of 150,300,450mg/kg. Group 7,8and 9 treated with methanolic leaf extract of Sesbania grandiflora Linn. Doses of 150,300,450mg/kg.Results: No change in body weight group treated with AE-150 (p>0.05) with AE-150 (0.1%), increase in urine volume with increasing doses both with aqueous and methanolic extracts, sodium excretion with methanolic extract was high compared with the aqueous extract, significant increase in potassium excretion in both aqueous and methanolic extract treated groups.All the statistical tests were done by using SPSS version 6. The level of significance was 5% (p≤0.05).Conclusions: All the electrolytes concentration was increased in the urine, hence excluding osmotic diuretic action. Diuretic index, saluretic activity, saluretic index and natriuretic index of ME-450 were more than the value of hydrochlorothiazide hence excludes thiazide diuretic action. But these values were less than furosemide.</jats:p
Effect of Aegle marmelos methanolic extracts of leaf and fruit pulp on learning and memory in albino rats
No full textBackground: The objective was to study the effect of Aegle marmelos methanolic extracts of leaf (LE) and fruit pulp extract (FE) on learning and memory in albino rats. 40 healthy wistar albino rats of either sex were randomly divided into 10 groups of 4 each (n=4), weighing about 150 to 200 gm were selected for the study. The extracts i.e. 1ml of 1% carboxy methyl cellulose, LE and FE at doses of 100 mg/kg and 200 mg/kg were administered per oral one hour before the experiment.Methods: Learning and memory was assessed by elevated plus maze and Hebb William maze. Latency time and number of entries were assessed by elevated plus maze whereas only latency was assessed by Hebb William maze.Results: Plant extracts of LE and FE at doses 100 mg/kg and 200 mg/kg have shown significant percentage reduction in latency time in elevated plus maze and Hebb William maze (p<0.05) and reduction in the number of entries in elevated plus maze.Conclusions: LE and FE at doses 200 mg/kg have shown significant effect on learning and memory
Study of awareness of diabetes mellitus among diabetics and non-diabetics and drug utilisation pattern in diabetics attending tertiary care general hospital in India
No full textBackground: Diabetes Mellitus (DM) is one of the most challenging public health problems. It is important to know about the awareness level of a disease condition in a population, which plays a vital role in future development, early detection and prevention of disease.Methods: A total of 200 subjects were interviewed and their details were noted in a specially designed data collection form. The questionnaire contained a series of questions related to demographic characteristics and awareness of DM including general knowledge, risk factors and complications of diabetic and non-diabetic patients.Results: Among 150 subjects were diabetic and 50 were non-diabetic. 60 (40%), 14(28%) of diabetics and non- diabetics were between the age of 41-50. 101 (67.3%) were male, 49 (32.6%) were female. 101 (67.3%) of the study participant had family history of diabetes in diabetic. 45 (44.5%) diabetic, 20 (40.81%) non-diabetic male knows the risk factor for diabetes mellitus and 35 (34.6%), 21 (42.8%) were aware of symptoms, 09(8.9%), 03(6.1%) awareness on complication of diabetes. 21 (20.7%), 06 (12.2%) doesn’t know about Risk factors.Conclusions: The present study conclude a current situation of knowledge and awareness of diabetes mellitus and also emphasizes the need for improvement in knowledge and awareness on diabetes mellitus among the diabetic as well as non-diabetic subjects in order to achieve prevention and better control of diabetes risk factors, complications and its management.</jats:p
