302 research outputs found
Magnetic resonance imaging and spectroscopic markers for the detection and metabolic characterisation of IDH-mutant gliomas
No full textBackground: The discovery of mutations in the isocitrate dehydrogenase (IDH) 1/2 gene induced a paradigm shift in the determination of diagnosis, prognosis and treatment of glioma. In 2016 the World Health Organisation (WHO) incorporated mutations in IDH1/2 into the diagnostic criteria for intracranial tumours as they have been demonstrated in 70-80% of WHO grade II-III gliomas, as well as in grade IV secondary glioblastoma (GBM)1 . Methods: This thesis explores several methods to further investigate and understand the noninvasive detection of IDH mutation as well as the pathophysiology of the mutation. Firstly, the extraction of quantitative features from MR images of glioma patients, and the subsequent application of machine learning strategies in order to carry out non-invasive classification according the IDH mutational status. Second was use a metabolomics analytical approach to 1 and 2 dimensional NMR spectroscopy to understand the metabolic implications of the presence of the mutation. Finally, the exploration of the utility of a novel magnetic resonance spectroscopy (MRS) sequence for the non-invasive detection of the IDH mutation induced oncometaboite 2-hydroxygluerate (2-HG). Results: The use of ... (continues
Modeling and analysis of forced vibrations in microstretch thermoelastic beam resonators using dual phase lagging model
No full textThe laughter of the fish: Paths to feminine individuation in India
No full textIndian mythology and literature are replete with examples of beautiful daughters who grace the house of illustrious fathers. The giving away of the daughter in marriage is the single biggest form of daan in Hindu culture, highlighting the sanctity of the daughter in the Indian psyche. What does it mean to be the daughter? How does the father present himself in the psyche of the Indian woman? As an embodiment of the wild woman archetype, the Indian woman shares a unique position with the father both in mythology and literature. This paper attempts to examine the father-daughter dynamic in Indian mythology through a select tale from the ancient fifteenth-century text Shuka Saptati. The interpretation offered paves a way for understanding the nuances of individuation in the feminine psyche
The Pandemic & the shadow: Reflections on the shadow archetype during Covid 19
No full textOne of the major psychological implications of the recent pandemic has been a heavy surge in cases reported around the world of troubled mental health. The mental health clinics were flooded as the world grappled to come to terms with loss of life and loneliness. The pandemic in many ways thus was a call for humanity to stop and turn inward to address the concerns of the psyche. The present paper attempts to re-visit the archetypal interpretation of Magyar-Germanic version of the tale of ‘the red shoes’ by noted Jungian Analyst Dr. Clarissa Pinkola Estés. The tale speaks about the psychological implications of being captured and starvation of the soul and brings forth a call for developing foresight for consequences of not paying enough attention to instinctual life. The tale has been interpreted by Dr. Estes to understand its implication for the feminine psyche. In the present paper, there is re-interpretation offered that extends beyond only the feminine psyche- it applies to humanity. The argument raised herein is that Covid 19 has hit us hard because during today’s modern times, we do not pay enough attention to our inner development. In the run for materialism, there is little or no time offered for oneself- to look inward, face one’s own reality and meet the individual demands of the psyche. Therefore, calamities like the pandemic bring us down to the ground and force us to face our inner shadow. Understanding of the Jungian notion of the archetype of the shadow, its manifestation during the pandemic and its implications for the psyche in today’s time enables us to seek an answer to what must now be done to restore our psychological health and vitality post the pandemic
Bridging the Rice Yield Gaps under Drought: QTLs, Genes, and their Use in Breeding Programs
No full textRice is the staple food for more than half of the world’s population. Although rice production has doubled in the last 30 years as a result of the development of high-yield, widely adaptable, resource-responsive, semi-dwarf varieties, the threat of a food crisis remains as severe as it was 60 years ago due to the ever-increasing population, water scarcity, labor scarcity, shifting climatic conditions, pest/diseases, loss of productive land to housing, industries, rising sea levels, increasing incidences of drought, flood, urbanization, soil erosion, reduction in soil nutrient status, and environmental issues associated with high-input agriculture. Among these, drought is predicted to be the most severe stress that reduces rice yield. Systematic research on drought over the last 10 years has been conducted across institutes on physiology, breeding, molecular genetics, biotechnology, and cellular and molecular biology. This has provided a better understanding of plant drought mechanisms and has helped scientists to devise better strategies to reduce rice yield losses under drought stress. These include the identification of quantitative trait loci (QTLs) for grain yield under drought as well as many agronomically important traits related to drought tolerance, marker-assisted pyramiding of genetic regions that increase yield under drought, development of efficient techniques for genetic transformation, complete sequencing and annotation of rice genomes, and synteny studies of rice and other cereal genomes. Conventional and marker-assisted breeding rice lines containing useful introgressed genes or loci have been field tested and released as varieties. Still, there is a long way to go towards developing drought-tolerant rice varieties by exploiting existing genetic diversity, identifying superior alleles for drought tolerance, understanding interactions among alleles for drought tolerance and their interaction with genetic backgrounds, and pyramiding the best combination of alleles
Fragmentation cross-section study of 28Si ions on 12C target with simulation toolkit GEANT4
No full textBridging the rice yield gaps under drought: QTLs, genes, and their use in breeding programs
No full textRice is the staple food for more than half of the world’s population. Although rice production has doubled in the last 30 years as a result of the development of high-yield, widely adaptable, resource-responsive, semi-dwarf varieties, the threat of a food crisis remains as severe as it was 60 years ago due to the ever-increasing population, water scarcity, labor scarcity, shifting climatic conditions, pest/diseases, loss of productive land to housing, industries, rising sea levels, increasing incidences of drought, flood, urbanization, soil erosion, reduction in soil nutrient status, and environmental issues associated with high-input agriculture. Among these, drought is predicted to be the most severe stress that reduces rice yield. Systematic research on drought over the last 10 years has been conducted across institutes on physiology, breeding, molecular genetics, biotechnology, and cellular and molecular biology. This has provided a better understanding of plant drought mechanisms and has helped scientists to devise better strategies to reduce rice yield losses under drought stress. These include the identification of quantitative trait loci (QTLs) for grain yield under drought as well as many agronomically important traits related to drought tolerance, marker-assisted pyramiding of genetic regions that increase yield under drought, development of efficient techniques for genetic transformation, complete sequencing and annotation of rice genomes, and synteny studies of rice and other cereal genomes. Conventional and marker-assisted breeding rice lines containing useful introgressed genes or loci have been field tested and released as varieties. Still, there is a long way to go towards developing drought-tolerant rice varieties by exploiting existing genetic diversity, identifying superior alleles for drought tolerance, understanding interactions among alleles for drought tolerance and their interaction with genetic backgrounds, and pyramiding the best combination of alleles
Aesthetic principles and cognitive emotion appraisals: How much of the beauty lies in the eye of the beholder?
No full textLow Cost Airlines in a Developing Economy: The Case of India
No full textThis dissertation is a study on the low cost airlines in a developing country, particularly the case of India, since the writer of this dissertation is an Indian. It begins with introducing the emergence of low cost airlines all around the world, which began with the US and was followed by Europe, before coming to Asia. It talks about the factors that initiated the emergence of low cost airlines, particularly, the deregulation of the air transport industry and the technological changes along with internet. It moves on to describe the economy of India dating back to the British colonial rule, how the economy has transformed today, from a poor country to the fastest growing economy in the world. A brief overview of the other modes of transport dominant in the country is given, especially the Indian Railways, followed by a detailed study of the Airline Industry in India, its deregulation, various policy changes that took place from time to time, the emergence of low cost airlines with a brief description of the low cost airlines operating in India. Subsequently, it deals with a research done by the author to give her contribution in this field of study. The analysis is divided into two parts. The first part deals with a primary research undertaken by the author with the help of questionnaires to find out customer attitude towards low cost airlines. The second part is a secondary research with has been analyzed in further detail to support the primary research. Finally, the conclusion gives a general idea of the main findings of the research along with some policy recommendations to the industry as a whole
- …
