605 research outputs found
Nithin Kumar's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Nithin Kumar's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Loading as a design parameter for genetic circuits
Get PDFA significant problem when building complex biomolecular circuits is due to context-dependence: the dynamics of a system are altered upon changes to its context, potentially degrading the system's performance. Here, we study retroactivity, a specific type of context-dependence, by analyzing the effects of loads on a transcription factor applied by the transcription factor's target sites. In particular, we study this loading effect on the model of an activator-repressor oscillator, a widely studied motif in synthetic and systems biology. Our analysis indicates that strong activation and weak repression are key for a stable limit cycle. Repression can be effectively weakened by adding load to the repressor, while activation can be effectively weakened by adding load to the activator. Therefore, loading the repressor can be employed as a design parameter to establish a stable limit cycle. In contrast, loading the activator is deleterious to the clock
25 GHz, 1 mV input resolution auxiliary circuit assisted comparator in 65 nm CMOS process
No full textThe need for the high-speed analogue-to-digital converters demands the use of regenerative comparators. The strong positive feedback present in the regenerative comparators helps the comparator to work efficiently at the high-speed operations. This work proposes a low power auxiliary circuit to improve the high-frequency performance of the comparator. The proposed architecture along with the conventional comparators is simulated in 65-nm complementary metal oxide semiconductor (CMOS) technology with a supply voltage of 0.9 V. The maximum operating frequency of the proposed comparator is 6.25 GHz for a differential input voltage of 1 mV
Current Conveyor based Novel Gyrator filter for Biomedical Sensor Applications
No full textThis paper presents a lossy gyrator, which is used to implement a universal second order current mode filter. The proposed lossy gyrator uses conventional Second Generation Positive Current Conveyor (CCII) as a basic building block, which has -3 dB bandwidth of 230 MHz and a total power consumption of 15.31 mu mathbf{W}. A universal second order current mode filter is designed using proposed lossy gyrator, which achieves a high cutoff frequency of 18 Hz in low pass mode, a low cutoff frequency of 345 Hz for high pass, and a band pass response with resonating frequency at 90 Hz with a total power dissipation of 57 mu mathbf{W}. Simulation is done using standard 180 nm CMOS technology at ±0.5 V supply voltage
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