1,722,044 research outputs found
Constitutionalizing E-mail Privacy by Informational Access
Full text linkKumar, Manish. (2007). Constitutionalizing E-mail Privacy by Informational Access. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/155630
Replication Data for: Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics
No full textCancer is a fatal genetic disease with varying complexities, including immune evasion, treatment resistance and recurrence, and optimized treatment is needed for a proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity of cancer development, which is ultimately linked to its genetic machinery. Importantly, patients with the same type of cancer respond differently to available cancer treatments, indicating the need for patient-specific treatment options. Thus, in-depth genomic studies of patients’ tumors are needed to fully understand the determinants of cancer initiation and progression for effective targeted therapy. Precision oncology has evolved as a form of cancer therapy focused on genetic profiling of tumors to identify molecular alterations involved in cancer manifestation for tailored individualized treatment of the disease. There have been great developments in the formulation and production of anticancer agents in recent years, mainly owing to advances in molecular technologies enabling precise targeting of oncogenic pathways involved in disease progression. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of advancements in the tools and techniques associated with the process to assess its scope and importance in realizing the intended goals
Replication Data for: Precision Medicine Approach to Signal Based Targeted Therapy of Cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Thus, precision oncology that relies on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article intends to comprehensively elucidate the foundations and frontiers of precision oncology in the context of recent advances in the field of cancer genomics and single-cell technology for efficient cancer treatment
Precision Medicine Approach to Signal Based Targeted Therapy of Cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Thus, precision oncology that relies on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article intends to comprehensively elucidate the foundations and frontiers of precision oncology in the context of recent advances in the field of cancer genomics and single-cell technology for efficient cancer treatment
Replication Data for: Precision Oncology bringing a paradigm shift in the treatment of cancer
No full textThe genetic changes appearing in the information system of the cells that program its unregulated growth and proliferation gradually lead to cancer manifestation and the treatment options must be guided accordingly. The critical roles played by some of the molecules associated with the specific signaling pathways and cell microenvironment that lead to oncogenesis and metastasis have been described precisely in recent years based on findings of the human genome project. Precision oncology relying on the genomic study of the cancer cells to better understand the prognosis and pathways involved with disease progression for the cure is destined to serve the purpose adequately. This article tries to comprehensively elucidate the foundations and frontiers of precision oncology in the context of single-cell technology for efficient cancer treatment
Replication Data for: Precision Oncology, Cell Signaling and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics
No full textIn recent decades, there has been a deluge in the large-scale production of anticancer agents, primarily due to advances in genomic technologies enabling precise targeting of oncogenic pathways involved in disease progression. This initiated a paradigm shift in cancer research and therapeutics based on the ability to study molecular changes throughout the genome. It provided a unique opportunity in the field of translational cancer research and have led to the concept of precision medicine in cancer therapy, raising hopes of developing better diagnostic and therapeutic means for the management of cancer. The purpose of this article is to briefly review the tools and techniques involved in precision oncology research and their applications in the field of cancer treatment
Biocatalytic route to C-3?-azido/-hydroxy-C-4?-spiro-oxetanoribonucleosides
Full text linkThe lipase, Novozyme®-435, exclusively deacetylates the 5-O-acetyl over 4-C-acetyloxymethyl group of almost identical reactivity in 5-O-acetyl-4-C-acetyloxymethyl-3-azido-3-deoxy-1,2-O-isopropylidene-?-D-ribofuranose that led to the development of first and efficient synthesis of 3?-azido-/3?-amino-C-4?-spiro-oxetanoribonucleosides T, U, C and A in 20–24% overall yields. The X-ray study on the compound obtained by tosylation of lipase-mediated monodeacetylated product unambiguously confirmed the point of diastereoselective monodeacetylation on diacetoxy-azido-ribofuranose derivative. The capability of Novozyme®-435 for selective deacylation of 5-O-acetyl group in 5-O-acetyl-4-C-acetyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-?-D-ribofuranose recently discovered by us has been successfully used for the synthesis of C-4?-spiro-oxetanoribonucleosides A and C in good yields. These results clearly indicate that the broader substrate specificity and highly selective capability of Novozyme®-435 for carrying out acetylation/deacetylation reactions can be utilized for the development of environment friendly selective methodologies in organic synthesis
EFFECT OF VARIOUS PREPARATORY TILLAGE SYSTEMS ON SOYBEAN PERFORMANCE ON MORE THAN SEVEN YEARS UNCULTIVATED VERTISOL OF CENTRAL INDIA
No full textSheilendra Kumar*, Manish R. Deshmukh, Pramod Kumar and Subhradip Bhattacharje
GROWTH ANDPRODUCTIVITY OF SOYBEAN AS INFLUENCED BY PREPARATORY TILLAGE SYSTEM ON MORE THAN SEVEN YEARS UNCULTIVATED LAND
No full textSheilendra Kumar*, Manish R. Deshmukh, Pramod Kumar and Subhradip Bhattacharje
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