2,308 research outputs found
TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
No full textBackground/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis. Mainly reported in proximal regions of the kidney, EMT is now recognized as a key contributor to the loss of renal function throughout the nephron in diabetic nephropathy (DN). Concomitant upregulation of TGF-beta in diabetes makes this pro-fibrotic cytokine an obvious candidate in the development of these fibrotic complications. This article reviews recent findings clarifying our understanding of the role of TGF-beta and associated sub-cellular proteins in EMT. Methods: To understand the pathology of EMT and the role of TGF-beta, we reviewed the literature using PubMed for English language articles that contained key words related to EMT, TGF-beta and DN. Results: EMT and phenotypic plasticity of epithelial cells throughout the nephron involves cytoskeletal reorganization and de novo acquisition of classic mesenchymal markers. Concurrent downregulation of epithelial adhesion molecules results in a loss of function and decreased cell coupling, contributing to a loss of epithelial integrity. TGF-beta 1 is pivotal in mediating these phenotypic changes. Conclusion: TGF-beta-induced EMT is a key contributor to fibrotic scar formation as seen in DN, and novel routes for future therapeutic intervention are discussed
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ...
No full textDISPUTATIO MEDICA DE GENERATIONE HOMINIS IN OVO / QUAM, ... SUB PRAESIDIO ... DN. JOHANNIS JACOBI WALDSCHMIED/ MEDICINAE DOCTORIS ... EXHIBET AUTHOR DOMINICUS BEDDEVOLE, GENEVENSIS, IN AUDITORIO MEDICO D. 3. SEPTEMB. ...
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ... (1)
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Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens
No full textCONSENSU ET AUTHOR. MAGNIFICI ICTORUM ORDINIS IN ILLUSTRI AD SALAM ACADEMIA, SUB PRAESIDIO ... DN. JOH. VOLK. BECHMANNS ... DISSERTATIONEM IURIDICAM DE IURE BRAXANDI IN ICTORUM AUDITORIO AD DIEM OCTOBR. H.C. PUBLICAE ERUDITORUM CENSURAE SUBIICIET PAUL. CHRISTIANUS ARNOLDUS, OLSNEN. SILES. AUTHOR & RESPONDENS
Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens ([1])
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De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI.
No full textDE. CONDICTIONE L. SI QUIS CONDUCTIONIS. 25. C. DE LOCATO CONDUCTO. SUB PRAESIDIO DN. ANDREAE MYLII ... PUBLICE DISPUTABIT. AUTHOR. JOHANN GOTTFRIED SCHÖNFELD/ ZITT. LUS. DIE 11. IUNII. M.DC.XCVI.
De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI. (1)
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The DN-PUBLIC framework for enhanced oral healthcare precision: a public health strategy for dynamic navigation integration—a narrative review
No full textOral health disparities remain a pressing global concern, especially in communities with limited access to specialized dental care. Implant dentistry, while transformative for tooth replacement, often relies on techniques that can be imprecise, operator-dependent, and prone to complications. Dynamic Navigation (DN), a real-time computer-assisted technology, offers a promising solution by enhancing accuracy, reducing errors, and supporting minimally invasive procedures. This narrative review explores how DN can improve clinical precision, reduce surgical complications, and make implantology more accessible and cost-effective. It introduces the DN-PUBLIC framework—a strategic, public health-focused approach for integrating DN into broader healthcare systems, with a strong alignment to the United Nations Sustainable Development Goals (SDGs).A comprehensive review of current literature was conducted, assessing DN's impact on surgical safety, recovery outcomes, cost-efficiency, and its growing role in dental education. The findings highlight that DN significantly improves implant placement accuracy and reduces risks such as nerve injury or misalignment. By allowing for flapless procedures and better soft tissue preservation, DN leads to quicker recovery and greater patient comfort. Beyond clinical outcomes, DN enables general practitioners to perform complex procedures more confidently, expanding access to quality care in underserved regions. Economic analyses also suggest reduced operative time, fewer complications, and lower healthcare costs. In conclusion, DN has the potential to transform public oral health by improving outcomes, training, and access. The DN-PUBLIC framework offers a clear roadmap to guide ethical, inclusive, and sustainable integration of DN technology in dental practice worldwide
Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV.
No full textDISSERTATIO DE CENSU AUGUSTI / QUAM SUB PRAESIDIO ... DN. ULRICI OBRECHTI, IN ALMA ARGENTINENSIUM UNIVERSITATE PROFESSORIS HISTOR. ... AD EXAMEN SOLENNE PROPONIT MICHAEL FÖRTSCH/ WERTHEIMIO-FRANCUS AUTHOR. A. D. [...] MAII MDCLXXV.
Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV. (1)
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Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum
No full textTRACTATIO IURIS PUBLICI DE SERENISSIMIS POTENTISSIMISQUE DUCIBUS BRUNSVICENSIBUS ET LUNEBURGENSIBUS / D.O.M.A. PRAESIDE ... DN. JOH. ULRICO PREGIZERO ... IN ILLUSTRI COLLEGIO AD DIEM 10. DECEMBR. PLACIDO ERUDITORUM EXAMINI SISTIT AUTHOR CHRISTIAN ULRICH BLUM
Tractatio Iuris Publici De Serenissimis Potentissimisque Ducibus Brunsvicensibus Et Luneburgensibus / D.O.M.A. Praeside ... Dn. Joh. Ulrico Pregizero ... In Illustri Collegio Ad Diem 10. Decembr. Placido Eruditorum Examini sistit Author Christian Ulrich Blum (1)
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Axonchium indicum Kumar & Ahmad 2023, sp. nov.
No full text<i>Axonchium indicum</i> sp. nov. <p>urn:lsid:zoobank.org:act: 116B7509-1BE9-4315-A6D7-5B819B4C2789</p> <p>Figs 5–6, Table 5</p> Diagnosis <p> <i>Axonchium indicum</i> sp. nov. is characterized by having a 1.2–1.4 mm long body; lip region angular and offset; odontostyle fusiform, 8–9 µm long; the two parts of the pharynx separated by a deep constriction; expanded part of pharynx short, occupying about 39–49% of total neck length; vagina lumen narrow with thickened walls, slightly bent posteriorly; vulva transverse and pre-equatorial; anterior uterine sac short, 0.9–1.6 times the mid-body diameter; tail bluntly conoid.</p> Etymology <p>The new species is named after its country of origin, India.</p> Material examined <p> <b>Holotype</b> INDIA <b>•</b> ♀; Kerala State, Kollam District, Pathanampuram; 9°5ʹ27.5136ʺ N, 76°53ʹ22.6702ʺ E; 10–15 cm depth; 3 Nov. 2017; roots of grasses (unidentified); slide reference number AMU/ZD/NC/ <i>Axonchium indicum</i> /1.</p> <p> <b>Paratypes</b> INDIA <b>•</b> 6 ♀♀; same collection data as for holotype; slide reference number AMU/ZD/NC/ <i>Axonchium indicum</i> /2–3 • 2 ♀♀; same collection data as for holotype; slide reference number AMU/ZD/ NC/ <i>Axonchium indicum</i> /4, nematode collection of the Zoological Survey of India, Kolkata, India.</p> Type habitat and locality <p>Soil samples collected around the roots of grasses (unidentified) from Pathanampuram, Kollam District, Kerala State, India.</p> Description <p> <b>Female</b></p> <p> Body curved ventrad upon fixation, 1.2–1.4 mm long. Cuticle with fine transverse striations, about 1–2 µm thick at the anterior, 1–2 µm at mid-body, and 4–5 µm on tail tip. Lateral chords 5–7 µm wide, or 1/ 7 to 1/ 5 (14–20%) of mid-body diameter with indistinct glandular bodies. Lateral, dorsal and ventral body pores indistinct. Lip region angular, offset by deep constriction, 2.0–2.5 times as wide as high, or about 1/ 5 to ¼ (22– 25%) of body diameter at neck base. Lips incompletely separate.Amphid fovea stirrup-shaped, their aperture occupying about 0.7–0.8 times lip region diameter, fusus just opposite or slightly posterior to odontophore level. Guiding ring single, at 0.9–1.1 times lip region diameter from anterior end. Odontostyle fusiform, 4.0–4.5 times as long as wide, or 0.9–1.1 times lip region diameter long, its aperture occupying about ⅓ of its length. Odontophore simple, rod-like, 1.2–1.6 times as long as odontostyle. Nerve ring encircling anterior slender part of pharynx at 28–33% of neck length from anterior end. Anterior slender part of pharynx quite muscular, separated from posterior expanded part by a deep constriction. Expanded part of pharynx 6.0–10 times as long as wide, or 3.7–5.6 times as long as body diameter at neck base, and occupying about 2/ 5 to ½ (39–49%) of total neck length, enclosed in a thick muscular sheath with straight bands. Only dorsal pharyngeal gland and its orifice visible: DO = 53–62; DN = 55–64; DO–DN = 0.3–1.9. Cardia oblong, 1.1–2.0 times as long as wide, and occupying about 2/ 7 to 2/ 5 (28–37%) of corresponding body diameter.</p> <p>Genital system mono-opisthodelphic. Anterior genital branch represented by a small sac, measuring 35–59 µm or 0.9–1.6 times mid-body diameter long, and occupying about 2.6–4.7% of total body length. Posterior branch well developed; ovary reflexed, measuring 43–71 µm long with squamous shaped oocytes arranged in a single row except near tip; oviduct joining ovary subterminally, measuring 35–70 µm or 1.0–1.9 times mid-body diameter long, consisting of a long slender part with prismatic cells and a wide pars dilatata; oviduct-uterus junction marked by sphincter; uterus 46–68 µm or 1.2– 1.9 times mid-body diameter long, differentiated into a large proximal part with distinct lumen, and a short spherical pars dilatata with clear lumen; sperms not observed. Vulva transverse. Vagina slightly bent posteriad, extending inwards about ½ to three-fifths (52–60%) of corresponding body diameter long, vaginal lumen slender with thickened distal region but not differentiated from body cuticle; pars proximalis vaginae slender, surrounded by well-developed circular musculature; pars refringens vaginae absent; pars distalis vaginae 7–9 µm long. Prerectum 5.2–9.0 and rectum 1.2–1.5 times anal body diameter long. Tail short, bluntly conoid. Caudal pores two on each side.</p> <p> <b>Male</b></p> <p>Not found.</p> Taxonomic remarks <p> The new species differs from all known species of <i>Axonchium</i> in its comparatively short posterior expanded part of the pharynx. However, it comes close to <i>A. nitidum</i> Jairajpuri, 1964 in its body size and tail shape, but differs from it in having a shorter pharynx (b = 3.3–3.7 vs 2.2–3.0); anterior vulva position (V = 45–48 vs 52–53); longer anterior uterine sac (G1 = 2.5–4.7 vs 0.8–1.3 or 0.9–1.6 vs 0.5 times the corresponding body diameter long) and male not found (vs known).</p> <p> In the body size and vaginal character, the new species also resembles <i>A. perplexans</i> Siddiqi, 1995 but differs in having a robust body (a = 34–38 vs 49–57); shape of lip region (angular vs hemispheroid); shorter pharynx (b = 3.3–3.7 vs 2.8–3.0); anterior vulva position (V = 45–48 vs 54–56); longer anterior uterine sac (0.9–1.6 times vs less than corresponding body diameter long); and tail shape (conoid vs hemispherical to clavate).</p> <p> The new species also resembles <i>A. bulbosum</i> Williams, 1958 but differs in the shape of the lip region (angular lips vs with rounded outer and inner portion); shorter pharynx (b = 3.3–3.7 vs 2.4–2.9); anterior vulva position (V = 45–48 vs 55–57); slightly longer anterior uterine sac (G1 = 2.5–4.7 vs 1.7–2.3 or 0.9–1.6 times vs shorter than corresponding body diameter long); the nature of the vagina (vaginal lumen slender, not enlarged vs distinctly enlarged with rounded or spheroid walls); and tail shape (conoid vs bulboid with extremely thick cuticle at terminus).</p>Published as part of <i>Kumar, Sumit & Ahmad, Wasim, 2023, Six new and four known species of the genus Axonchium Cobb, 1920 (Nematoda: Dorylaimida: Belondiroidea) from the Western Ghats of India, pp. 1-56 in European Journal of Taxonomy 857</i> on pages 17-21, DOI: 10.5852/ejt.2023.857.2039, <a href="http://zenodo.org/record/7629268">http://zenodo.org/record/7629268</a>
Rational conjugacy classes of maximal tori in groups of Dn
No full textAuthor original manuscript (preprint)We give a concrete characterization of the rational conjugacy classes of maximal tori in groups of type Dn, with specific emphasis on the case of number fields and p-adic fields. This includes the forms associated to quadratic spaces, all of their inner and outer forms as well as the Spin groups, their simply connected covers. In particular, in this work, we handle all (simply connected) outer forms of D4.N
Axonchium uniqum Kumar & Ahmad 2023, sp. nov.
No full textAxonchium uniqum sp. nov. urn:lsid:zoobank.org:act: 7F52E2C7-6005-4727-A949-4EE6C0DC4C51 Figs 15–16, Table 10 Diagnosis Axonchium uniqum sp. nov. is characterized by having a 1.7–2.0 mm long body; lip region offset; amphid fovea stirrup-shaped; odontostyle fusiform, 10–11 µm long; both part of the pharynx separated by a deep constriction; basal expanded part of pharynx 71–72% of total neck length; anterior uterine branch 2.5–2.8 times the mid-body diameter long; vulva transverse; vagina expanding gradually in middle; spicules slender, somewhat sickle-shaped, 68 µm long; nine irregularly spaced ventromedian supplements, beginning posterior to the proximal end of the spicules; lateral guiding pieces 20 µm long with bifurcate distal ends; tail broadly conoid. Etymology The new species is named A. uniqum because of the unique shape of its spicule. Material examined Holotype INDIA • ♀; Maharashtra State, Raigad District, Mahabaleshwar Hill; 17°55ʹ50.52ʺ N, 73°38ʹ51.72ʺ E; 10–15 cm depth; 12 Apr. 2016; roots of plants (unidentified); slide reference number AMU/ZD/ NC/ Axonchium uniqum /1. Paratypes INDIA • 3♀♀, 1♂;same collection data as for holotype; slide reference number AMU/ZD/NC/ Axonchium uniqum /2–3; nematode collection of the Zoological Survey of India, Kolkata, India. Type habitat and locality Soil samples collected around the roots of plants (unidentified) from Mahabaleshwar Hill, Raigad District, Maharashtra State, India. Description Female Body curved ventrad upon fixation, 1.7–2.0 mm long. Cuticle with fine transverse striations, about 2 µm thick at anterior region, 2–3 µm at mid-body and 8–10 µm on tail tip. Lateral chords 5–13 µm wide, about 1/ 10 to 1/ 5 (8–21%) of mid-body diameter; glandular bodies indistinct. Lateral, dorsal and ventral body pores indistinct. Lip region distinctly offset, 2.2–2.5 times as wide as high, or about 1/ 7 to 1/ 6 (14–16%) of body diameter at neck base. Lips low, bluntly conoid, incompletely separate. Amphid fovea stirrup-shaped, their aperture occupying about 0.7–0.8 times lip region diameter, fusus just opposite to odontophore level. Guiding ring single, at 0.9–1.1 times lip region diameter from anterior end. Odontostyle fusiform, 5.0–5.5 times as long as wide, 1.0–1.1 times longer than lip region diameter, its aperture occupying about ⅓ of its length. Odontophore simple, linear, 1.1–1.4 times as long as odontostyle. Nerve ring encircling anterior slender part of pharynx at 16–19% of neck length from anterior end. Anterior slender part of pharynx quite muscular, separated from posterior expanded part by a deep constriction. Expanded part of pharynx 16.5–16.8 times as long as wide, or 8.2–10.4 times as long as body diameter at neck base, and occupying about ¾ (71–72%) of total neck length, enclosed in a thick muscular sheath with straight bands. Only dorsal pharyngeal gland and its orifice visible: DO = 29; DN = 30; DO–DN = 0.3 (n = 1). Cardia oblong, 1.5–2.5 times as long as wide, occupying about ¼ to ⅓ (23–31%) of corresponding body diameter. Genital system mono-opisthodelphic. Anterior genital branch represented by simple uterine sac, measuring 147–171 µm or 2.5–2.8 times mid-body diameter long, occupying about 7.2–9.8% of total body length. Posterior branch well developed, its tract always appeared strongly convoluted; ovary reflexed, not reaching oviduct-uterus junction, measuring 63–95 µm long with squamous-shaped oocytes arranged in a single row except near tip; oviduct joining ovary subterminally, 82–90 µm or 1.3–1.5 times mid-body diameter long, consisting of a long slender tubular part with prismatic cells and a wider pars dilatata; oviduct-uterus junction marked by weakly developed sphincter; uterus 75–181 µm or 2.9–3.1 times midbody diameter long, differentiated into a relatively long and convoluted proximal region with wide lumen, and a spherical distal pars dilatata with distinct lumen. Vulva transverse. Vagina straight to slightly bent posterior, extending inwards about three-fifths (57–58%) of corresponding body diameter long; vaginal wall expanding gradually near middle, but not differentiated from body cuticle; pars proximalis vaginae longer than wide, 18–19 × 7–8 µm, surrounded by well developed circular musculature; pars refringens absent; pars distalis 16–17 µm long. Prerectum 3.7–5.6 and rectum 0.9–1.0 times anal body diameter long. Tail broadly conoid with rounded terminus. Caudal pores three on each side. Male Similar to female in general morphology, except for posterior region of body being more curved ventrad. Genital system diorchic, with oppositely outstretched testes; sperms ovoid, measuring 3–4 × 1–2 µm. In addition to adcloacal pair, located at 10 µm from cloacal aperture, a series of nine irregularly spaced ventromedian supplements, beginning at 30 µm from adcloacal pair, or posterior to proximal end of spicules. Copulatory muscles conspicuous, beginning from level of middle of spicules and continuing until level of last supplements. Spicules large, comparatively slender, ventrally arcuate, somewhat sickle-shaped in lateral view; total length along arc 1.5 times as long as chord, or 11.3 times maximum width, and about 1.9 times body diameter at cloacal aperture; curvature about 132˚. Dorsal contour irregularly convex, bulge at level of hump, ventral contour concave, bearing a distinct hump, located at 45.6% of spicule total length from its anterior end; head slender with slightly curved tip, occupying about 22.1% of total spicule length; median piece simple, 20.8 times as long as wide, and occupying about 41.6% of spicule maximum width; posterior end about 2 µm wide. Lateral guiding pieces almost straight with bifurcated distal end, about 10 times as long as wide, or about ⅓ (31%) of total spicule length. Prerectum 9.3 and rectum 1.2 times cloacal body diameter long. Tail similar to that of female but having slight depression on ventral side. Caudal pores four on each side. Taxonomic remarks In having large and slender spicules and in the arrangement of its ventromedian supplements, the new species comes close to A. sabulum (Yeates, 1967) sensu Coomans & Yeates 1969 and A. sinclairi Heyns & Furstenberg, 1993, but it differs from both, in its unique spicular morphology (large, sickleshaped). It further differs from the former in having a robust body (a = 29–34 vs 43–44); narrower lip region with comparatively low lips (9–10 vs 12 µm wide with comparatively high lips); longer pharynx (b = 2.1– 2.6 vs 3.6–3.7); shorter prerectum (3.7–5.6 vs 9–10 times the anal body diameter long); vagina expanded near the middle (vs not expanded); in shape and size of spicules (69 µm with dorsal contour irregularly convex, bulge at level of hump vs 50–56 µm with simple regularly convex dorsal contour); longer lateral guiding pieces (20 vs 10 µm); in the number and arrangement of ventromedian supplements (9 beginning from posterior to the proximal end of the spicules vs 5–6 starting just opposite to the proximal end of the spicules) and its comparatively longer tail (c = 53–68 vs 81–86). From A. sinclairi, it differs in the absence of a hemizonid (vs present at level of nerve ring); narrow lip region (9–10 vs 13–15 µm), lips low and incompletely separate (vs well separated from each other with outer and inner portions prominently demarcated by a depression); narrower amphid aperture (6–7 vs 9 µm wide); single guiding ring (vs double); comparatively longer pharynx (b = 2.1–2.6 vs 2.6–3.0); vagina almost straight to slightly posteriorly bent with its walls expanded in the middle (vs posteriad directed and its walls thicker but not expanded); shorter prerectum (3.7–5.6 vs 7 times the anal body diameter long); in shape and size of spicules (vs 78–81 µm long, strongly curved ventrad with simple regularly convex dorsal arm); lateral guiding pieces rod-shaped with bifurcated distal ends (vs simple arcuate without bifurcated distal end) and its longer tail (c = 53–68 vs 80–114).Published as part of Kumar, Sumit & Ahmad, Wasim, 2023, Six new and four known species of the genus Axonchium Cobb, 1920 (Nematoda: Dorylaimida: Belondiroidea) from the Western Ghats of India, pp. 1-56 in European Journal of Taxonomy 857 on pages 42-46, DOI: 10.5852/ejt.2023.857.2039, http://zenodo.org/record/762926
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