9,798 research outputs found
THE ART OF WINNING THE HEART : A review of Nandini Sahu\u27s A Song, Half & Half by Dinesh K Mali
No full textA Review of Nandini Sahu\u27s A Song, Half & Half by Dinesh K Mal
NMR based Synovial fluid metabolomics analysis of Reactive arthritis, Rheumatoid arthritis and Osteoarthritis
No full textReactive arthritis (ReA) is an inflammatory arthritis that often develops 2–4 weeks after an extraarticular infection with Chlamydia, Salmonella, Shigella, Campylobacter, and Yersinia species. Synovial fluid (SF) represents the diseased process under pathological conditions and its distinctive metabolic profiles may provide the diagnostic capacity and understanding of the disease state of reactive arthritis (ReA). The aim of this study is to identify characteristic metabolic changes that could differentiate ReA from non-ReA groups. The metabolic profiles of SF collected from ReA (n=58), rheumatoid arthritis (RA, n=21) and osteoarthritis (OA, n=20) patients were measured using NMR spectroscopy and compared using orthogonal partial least-squares discriminant analysis (OPLS-DA). Further, the receiver-operating characteristic (ROC) curve analysis was performed to establish the diagnostic potential of discriminatory metabolites. Finally, the correlation analysis of 38 metabolites between paired SF and serum from ReA patients was done using Pearson rank coefficient (r). The metabolomics profiles in synovial fluid were distinct between ReA, RA, and OA. The OPLS-DA demonstrated a distinctive metabolite profile of synovial fluid of ReA patient compare to RA RA and OA. Fourteen metabolites were obtained by VIP values of greater than 1 for both groups (ReA vs OA and ReA vs RA) and 12 and 6 of them were selected as potential biomarkers by student t-test for ReA vs OA and ReA vs RA groups. We utilized receiver operating characteristic analysis to determine the diagnostic value of each metabolite and identified in ReA compare to RA and OA as potential biomarkers, with an area under the ROC curve >0.8. A panel of six metabolites (NAG, glutamate, glycerol, isoleucine, alanine and glucose from ReA vs OA group) and two metabolites (alanine and carnitine from ReA vs RA group) was identified as a specific biomarker of ReA. Finally, the pearson correlation coefficient (r) between serum and SF ranged from -0.17 to 0.87 for each of the 38 metabolites, and 71% of the relations were significantly positive. Our approach successfully identified SF biomarkers associated with ReA patients that could serve as an efficient tool for early diagnosis of ReA and the role of these biomarker in the pathogenesis of ReA should be explored in future studies. This is the first study that establishes the correlation between metabolic profiles in SF and serum obtained from ReA patients.This is the first study on the metabolic signatures of diagnostic potential for Reactive Arthritis (ReA) identified by NMR based metabolomics analysis of human synovial fluid samples obtained from ReA and non-ReA (Rheumatoid Arthritis (RA) and Osteoarthritis (OA)) patients. Like RA, ReA is an inflammatory arthritis, whereas OA is non-inflammatory arthritis
Effect of water suppression and metabolite cycling on quantification of 1H MRS spectra in the human brain at 3 Tesla
No full textThe deposited data contain:
1) Ten datasets from five subjects, where each subject includes two water-suppressed metabolite spectra acquired using VAPOR and MC, along with the corresponding two water-reference scans acquired using VAPOR and MC.
2) Two datasets of macromolecule (MM) spectra, acquired using VAPOR and MC water-suppression techniques, summed across five subjects.
All datasets have been pre-processed (frequency, phase, and eddy-current correction applied) and summed. The data are provided in ASCII format.
For the metabolite datasets:
Column 1: real part of the metabolite FID
Column 2: imaginary part of the metabolite FID
Column 3: real part of the water FID
Column 4: imaginary part of the water FID
For the macromolecule datasets:
Column 1: real part of the MM FID
Column 2: imaginary part of the MM FID
All MRS data were acquired using a semi-LASER sequence (TE = 28 ms, spectral width = 6000 Hz, B₀ = 123.23 MHz). See the corresponding paper for additional details.Purpose: This study investigates the effect of VAPOR water suppression and metabolite cycling on metabolite quantification and macromolecules in proton magnetic resonance spectroscopy.
Methods: Single-voxel semi-LASER spectra (TR/TE=3000/28ms) and metabolite-nulled spectra (macromolecules) were acquired in 5 healthy subjects in the posterior cingulate cortex at 3T using two different water suppression schemes: VAPOR or metabolite-cycling (MC). Post-processed spectra were quantified using LCModel. Metabolites concentrations were compared between the two schemes.
Results: Region specific differences in macromolecules resonances were observed and the concentration of most metabolites was significantly higher when using MC compared to VAPOR. The difference was most pronounced for total creatine (-14% with VAPOR vs. MC, P<0.05).
Conclusion: The macromolecules spectrum included in the LCModel basis set must be measured with the same water suppression scheme as the metabolite spectrum for accurate quantification.This work was supported by NIH grants: R01 EB030000, P41 EB027061, P30 NS076408 and 1S10OD017974-01.Deelchand, Dinesh Kumar; Henry, Pierre-Gilles. (2026). Effect of water suppression and metabolite cycling on quantification of 1H MRS spectra in the human brain at 3 Tesla. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://hdl.handle.net/11299/278916
sj-docx-1-pie-10.1177_09544089231190223 - Supplemental material for Investigation of physical, chemical and mechanical behaviour of nano-ZrO<sub>2</sub>-based dental composite
No full textSupplemental material, sj-docx-1-pie-10.1177_09544089231190223 for Investigation of physical, chemical and mechanical behaviour of nano-ZrO2-based dental composite by Shiv Ranjan Kumar, Hari Om Sharma, Sachin Kumar and Dinesh Kumar Patel in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
A new species of Magnimyiolia Shiraki (Diptera: Tephritidae: Trypetinae) and new records of Acanthonevrini from India
No full textSingh, Shakti Kumar, David, K. J., Kumar, Dinesh, Ramamurthy, V. V. (2015): A new species of Magnimyiolia Shiraki (Diptera: Tephritidae: Trypetinae) and new records of Acanthonevrini from India. Zootaxa 3949 (1): 129-134, DOI: 10.11646/zootaxa.3949.1.
Water, human development and economic growth: some international perspectives
Get PDFWater resources developmentInvestmentWater storageEconomic aspectsSocial aspects
Large reservoirs: are they the last Oasis for the survival of cities in India?
Get PDFUrban water demand is rapidly growing in India due to high growth in urban population and rapid industrialization. Meeting this growing demand is a big challenge for the urban planners in India. Incidentally, urban areas in arid and semi arid regions of India are experiencing rapid growth. As a result, the supplies from local water resources including aquifers are far less than the high and concentrated water demands in most urban areas. Under such situations, the cities have to rely on large reservoirs. The paper argues that urban growth would be jeopardized in absence of water supplies from large reservoirs. The analysis of 302 urban centres shows that as population of cities grow, their reliance on surface water sources also grows. Also, greater the share of surface water in the city water supplies, better the level of water supply. A multiple regression analysis of 190 class I cities and 240 class II towns further supports this finding. In Class I cities, with every unit increase in population, there is a 1.12 unit increase in quantum of water supplies. Whereas in Class II towns, with every increase in population, there is only a 0.40 unit increase in quantum of water supply. This shows greater capacities of large cities to respond to the growing water demands, induced by population growth and urbanization. The future projections of population growth, economic development and future water demands clearly means that the role of large reservoirs in meeting the demand of urban water supply is going to be more critical.urban water supply; large reservoirs; urbanization; population growth; India.
Gaze-evoked amaurosis - post reconstruction of orbital floor fracture with a bone graft: Case report
No full textRicky Kumar, Simon N. Madge, Dinesh Selva, Phil Pirgousis and Alastair N. Gos
FIGURE 4 in First report of the moss Rhynchostegiella divaricatifolia (Renauld & Cardot) Broth. from Western Himalayan region of India
No full textFIGURE 4. Rhynchostegiella divaricatifolia, (A) whole plant, (B) & (C) leaves, (D) mid-leaf cells, (E) basal cells, (F) marginal cells, (G) leaf apex; A- C(10 x 10 X), D- G(10 × 45X).Published as part of Saxena, Dinesh K., Kumar, Saurabh & Saxena, Soniya, 2010, First report of the moss Rhynchostegiella divaricatifolia (Renauld & Cardot) Broth. from Western Himalayan region of India, pp. 59-64 in Phytotaxa 8 on page 63, DOI: 10.11646/phytotaxa.8.1.7, http://zenodo.org/record/489527
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