12 research outputs found
GRACE Score among Six Risk Scoring Systems (CADILLAC, PAMI, TIMI, Dynamic TIMI, Zwolle) Demonstrated the Best Predictive Value for Prediction of Long-Term Mortality in Patients with ST-Elevation Myocardial Infarction.
No full textTo compare the prognostic accuracy of six scoring models for up to three-year mortality and rates of hospitalisation due to acute decompensated heart failure (ADHF) in STEMI patients.A total of 593 patients treated with primary PCI were evaluated. Prospective follow-up of patients was ≥3 years. Thirty-day, one-year, two-year, and three-year mortality rates were 4.0%, 7.3%, 8.9%, and 10.6%, respectively. Six risk scores--the TIMI score and derived dynamic TIMI, CADILLAC, PAMI, Zwolle, and GRACE--showed a high predictive accuracy for six- and 12-month mortality with area under the receiver operating characteristic curve (AUC) values of 0.73-0.85. The best predictive values for long-term mortality were obtained by GRACE. The next best-performing scores were CADILLAC, Zwolle, and Dynamic TIMI. All risk scores had a lower prediction accuracy for repeat hospitalisation due to ADHF, except Zwolle with the discriminatory capacity for hospitalisation up to two years (AUC, 0.80-0.83).All tested models showed a high predictive value for the estimation of one-year mortality, but GRACE appears to be the most suitable for the prediction for a longer follow-up period. The tested models exhibited an ability to predict the risk of ADHF, especially the Zwolle model
ACE gene insertion/deletion polymorphism has a mild influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI
No full textAbstract Background We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction (MI) left ventricular dysfunction and acute heart failure (AHF) early after presentation with MI with ST-segment elevation (STEMI). Methods A total of 556 patients with STEMI treated by primary PCI (421 patients without AHF and 135 patients with AHF) were the study population. The activity of BNP, NT-ProBNP and ACE were measured at hospital admission and 24 h after MI onset. Left ventricular angiography was done before PCI; echocardiography was undertaken between the third and fifth day after MI. Results In comparison with the II genotypes group, the DD/ID group had a higher level of ACE activity upon hospital admission (p Conclusions These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.</p
Univariate and multivariate analysis of predictive ability for the components of given scores for prediction of 1-year mortality and one-year risk of rehospitalisation for ADHF.
No full text<p>*Recurrent MI, stroke, major bleed, CHF/shock, arrhythmia, renal failure</p><p><sup>1</sup> Statistical significance of AUC</p><p><sup>2</sup> Multivariate model consists of all statistical significant variables from univariate analysis</p><p>Univariate and multivariate analysis of predictive ability for the components of given scores for prediction of 1-year mortality and one-year risk of rehospitalisation for ADHF.</p
Landmark analyses of mortality after STEMI.
No full text<p>Landmark analyses of mortality after STEMI.</p
Cumulative occurrence of mortality and repeat hospitalisation for ADHF over time.
No full text<p>Cumulative occurrence of mortality and repeat hospitalisation for ADHF over time.</p
The AUC of six scoring models for mortality and rehospitalisation at a given time point and statistical significance of difference between AUC using DeLonges test (reference model GRACE score).
No full text<p>*/** Statistical significance of AUC p<0.05/p<0.001</p><p><sup>§</sup>/<sup>§§</sup> Statistical significance of difference between AUC using DeLonges test (reference model GRACE score) p<0.05/p<0.001</p><p>The AUC of six scoring models for mortality and rehospitalisation at a given time point and statistical significance of difference between AUC using DeLonges test (reference model GRACE score).</p
Predictive accuracy of scoring models for rehospitalisation due to ADHF during a three-year follow-up period.
No full text<p>Predictive accuracy of scoring models for rehospitalisation due to ADHF during a three-year follow-up period.</p
Baseline characteristics of patients and medical therapy upon hospital admission.
No full text<p>*Recurrent MI, stroke, major bleed, CHF/shock, arrhythmia, renal failure;</p><p>MI—myocardial infarction, ACEI—angiotensin-converting enzyme inhibitor, ARB—angiotensin II receptor blockers, PCI—percutaneous coronary intervention, CABG—coronary artery bypass grafting, TIA—transient ischaemic attack, AHF—acute heart failure.</p><p>Baseline characteristics of patients and medical therapy upon hospital admission.</p
Predictive accuracy of scoring models for mortality during a three-year follow-up period.
No full text<p>Predictive accuracy of scoring models for mortality during a three-year follow-up period.</p
Characteristics of laboratory tests and invasive procedures.
No full text<p>IRA—infarct-related artery, LAD—left anterior descending artery, CABG—coronary artery bypass graft, RCA—right coronary artery, RPLD—ramus posterolateral dexter, RIVP—ramus interventricularis posterior, RCx—ramus circumflexus, RMS—ramus marginalis sinister, RIM—ramus intermedius, RD—ramus diagonalis, BNP—brain natriuretic peptide, LVEF—left ventricular ejection fraction.</p><p>Characteristics of laboratory tests and invasive procedures.</p
