324,744 research outputs found
Inverse modelling of carbonyl sulfide: implementation, evaluation and implications for the global budget
No full textThe dataset is the boundary conditions of TM5-4DVAR inversions for COS tracer in years 2016-2019. The dataset is companion with publication:
Ma, J., Kooijmans, L. M. J., Cho, A., Montzka, S. A., Glatthor, N., Worden, J. R., Kuai, L., Atlas, E. L., and Krol, M. C.: Inverse modelling of carbonyl sulfide: implementation, evaluation and implications for the global budget, Atmos. Chem. Phys., 21, 3507–3529, https://doi.org/10.5194/acp-21-3507-2021, 2021
Leveraging diversity in American academic medicine. The Harold Amos Medical Faculty Development Program
No full textPeer reviewe
Lohnquote und Wachstumszyklus
No full textLohnquote und Wachstumszyklus : e. internat. Vergleich / Ekkehard von Knorring ; Gerd-Jan Krol. - In: Wachstumszyklen und Einkommensverteilung / hrsg. von Bernhard Gahlen. - Tübingen : Mohr, 1974. - S. 29-52. - (Schriften zur angewandten Wirtschaftsforschung ; 31
Waveguide fabrication in fused silica using tightly focused femtosecond laser pulses
No full textChan JW, Huser T, Risbud S, Krol DM. Waveguide fabrication in fused silica using tightly focused femtosecond laser pulses. In: Proc. SPIE Int. Soc. Opt. Eng.4640. 2002: 129
Interpolation of nonlinear positive or order preserving operators on Banach lattices
No full textWe study the relationship between exact interpolation spaces for positive, linear operators, for order preserving, Lipschitz continuous operators, and for positive Gagliardo–Peetre operators, and exact partially K-monotone spaces in interpolation couples of compatible Banach lattices. By general Banach lattice theory we recover a characterisation of exact interpolation spaces for order preserving, Lipschitz continuous operators in the couple (L1, L∞) due to Bénilan and Crandall
Nanomedicine for treatment of diabetes in an aging population: State-of-the-art and future developments
No full textNowadays diabetes, especially type 2 diabetes (which is strongly related to the Western diet and life-style), has developed worldwide into an epidemic disease. Nanomedicine aims to provide novel tools for diagnosis, therapy and point-of-care management of patients. Several nanotechnological approaches were developed to improve life quality for patients with insulin-dependent diabetes. They facilitate blood glucose management by non-invasive glucose measurement as well as insulin administration mainly by delivering the fragile protein as protected and targeted formulation via nasal or oral route. In the present review the oral or nasal insulin delivery by polymeric nanoparticles is discussed with focus on physiological change either related to the disease, diabetes or age-related metabolic variations influencing insulin release and bioavailability. One critical point is that new generations of targeted nanoparticle based drugs are developed and optimized for certain metabolic conditions. These conditions may change with age or disease. The influence of age-related factors such as immaturity in very young age, metabolic and physiologic changes in old age or insufficient animal models are still under-investigated not only in nanomedicine but also generally in pharmacology. Summarizing it can be noted that the bioavailability of insulin administered via routes others than subcutaneously is comparably low (max. 60%). Moreover factors like changed gut permeability as described for diabetes type 1 or other metabolic peculiarities such as insulin resistance in case of type 2 diabetes also play a role in affecting the development of novel nanoparticulated drug preparations and can be responsible for unsuccessful translation of promising animal results into human therapy. In future insulin nanoparticle development for diabetes must consider not only requirements imposed by the drug but also metabolic changes inflicted by disease or by age. Moreover new approaches are required for prevention of the disease
Lohnquote und Wachstumszyklus: ein internationaler Vergleich
No full textLohnquote und Wachstumszyklus : e. internat. Vergleich / Ekkehard von Knorring ; Gerd Jan Krol. - In: Wachstumszyklen und Einkommensverteilung / hrsg. von Bernhard Gahlen. - Tübingen : Mohr, 1974. - S. 29-52. - (Schriften zur angewandten Wirtschaftsforschung ; 31
Nanoparticelle di oro rivestite con polielettroliti e loro uso come medicamento per il trattamento di malattie neurodegenerative causate da aggregati proteici
No full textSemi-arid Northeast Brazil: integrated modelling of regional development and global change impacts
No full textSocieties in semi-arid areas in developing regions are amongst those most vulnerable to climate variability and potentially most vulnerable to climate change. The vulnerability to climate variability emerges from a combination of the level of availability of natural resources and the human dependency on these resources. In semi-arid regions, the limited availability of water and the low reliability of this availability pose strong restrictions on the use of natural resources. On the other hand, population often has a high density, and is strongly dependent on natural resources with little short-term options to reduce the dependency
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