183 research outputs found
John Frederick Knott - Bibliography from John Frederick Knott. 9 December 1938 — 5 October 2017
No full textJohn Knott was a leading expert in materials, fracture and structural integrity applied particularly to the fields of nuclear power generation and aero-engine applications. He made significant contributions to the quantitative scientific understanding of fracture processes in metals and alloys and its applications in engineering. His early work elucidated the role of microstructure in the initiation and propagation of cracks and involved detailed analysis of the micro-mechanisms of cleavage, ductile and fatigue fracture modes in many types of steel and non-ferrous alloys. He developed innovative techniques of mechanical testing which allowed detailed monitoring of crack propagation. He was the author of a much-used text book on the principles of fracture mechanics.The wide range of his expertise meant that John Knott was in high demand to serve on advisory committees for both government and industry organizations, particularly in the civil nuclear power generation and aerospace industries. With his deep knowledge of materials behaviour, he was invited to give many prestigious lectures at conferences. He was a convivial character with a keen sense of humour and often entertained conference dinners with poems he had composed about the particular event and about other participants
People, productivity and performance: the importance of workplace relations reform to Australia's resource future
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After the past decade of unprecedented global investment into new resource projects and existing mine expansions in Australia, the next few years will see a large number of these new mega-projects finish construction and enter the production phase.
During this industry transition, the performance and productivity of Australia's new resource projects will be critical for delivering the greatest returns to the nation and in determining whether more investment capital will find its way into the country.
As Australia's resource industry rapidly transitions into this new long-term production phase, the author, Australian Mines and Metals Association (AMMA) Chief Executive Steve Knott, discusses how leadership, productivity and workplace relations reform will maximise new production capacity and create ongoing opportunities for future generations. In particular, the author explores why Australia's workplace relations system is an increasing concern for an industry subject to intensifying global competition and the reforms that could assist resources companies to do business, invest and create jobs. This extended abstract about all things people and productivity will examine:
Australia's productivity performance against existing and emerging competitors.
The importance of workplace relations for boosting resource industry productivity and positioning Australia to secure further waves of global investment.
Key reform priorities for resource industry employers, and the workplace policy foundations that the industry needs for future productivity and competitiveness.
Labour productivity in the wider context of skills, leadership and technology usage.
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Sleep Deprivation Impairs Productivity in Adults With Mood Disorders: A Scoping Review
No full textAbstract
Date Presented 4/1/2017
Sleep deprivation (SD) is common in adults with mood disorders. Yet, little is known about how SD in adults with mood disorders may further restrict participation in occupations. This scoping review synthesized the literature on the effects of sleep deprivation on the productivity of adults with mood disorders.
Primary Author and Speaker: Melissa Knott
Contributing Authors: Christopher Derak, Lisa McAughey, Rashmi Mehrotra, Florence Roudbarani</jats:p
Miracle in the mundane poems, prompts, and inspiration to unlock your creativity and unfiltered joy
No full text"The national bestselling author of Chasers of the Light pulls back the curtain on his creative process to share how to unlock creativity and lead a more mindful and compassionate life Every day, Tyler Knott Gregson posts romantic and striking poems on Instagram, enchanting his many fans with his authentic and deeply personal voice. He has a remarkable ability to see the beauty within the seemingly mundane moments of our lives, and above all else this is what keeps his fans coming back for more. Tyler's newest book showcases his inspiring poems, but it also goes one step deeper to reveal his secrets to cultivating this sense of wonder for the world. In this insightful guide, you will learn how to uncover your creativity, find inspiration, and live a life that is "more." Through a series of challenges, you are encouraged to write, draw, photograph, and share as you discover how to see yourself in a new way. Featuring exercises on mindfulness and self-expression as well as a poem for every prompt, this book will broaden your heart and mind to see the miracles hidden all around you"--"The national bestselling author of Chasers of the Light pulls back the curtain on his creative process to share how to unlock creativity and lead a more mindful and compassionate life"-
Pandarus rhincodonicus Norman & Newbound & Knott 2000, sp. nov.
No full textPandarus rhincodonicus sp. nov. (®gures 1±5) Material HOLOTYPE: female Western Australian Museum (WAM) C 23238; ALLOTYPE: male WAM C 23239; PARATYPES: WAM C 23240. The senior author holds additional specimens and DRN holds the dissected material. Female (®gures 1±3) Body form shown in ®gure 1A and B. Length range 7.0±8.0 mm (mean = 7.6 mm, n = 10). Width range 3.83±4.28 mm (mean = 4.1 mm, n =10), with greatest width at cephalon, just anterior to the cephalon/thoracic junction. Height range 1.19±1.58 mm (1.4 mm, n =10). Although dorsal surface of body is smooth, pores are scattered across surface. Lateral margins of carapace are ¯eshy and with frill (®gure 2A). Frontal plates well developed and narrow mesial extensions meet in midline. First pediger fused with head; hinder margin of cephalon with four or ®ve robust spines (sometimes heavily eroded), with another two on each extension of the cephalon. Dorsal thoracic plates on pedigers 2±4. Pediger 2: plates separate, extending beyond tip of pediger 3 almost to level of posterior limit of plates of pediger 4; straight posterior margin with four sharp spines. Plates of pediger 3 and 4 fused at their bases; posterior margins with shallow sinuses. Plates of pediger 4 extend over base of genital double somite. Genital double somite: almost circular; with well-de®ned posterior projections (separated by a narrow sinus), each bearing an upturned triangular projection dorsally; often with a sub-marginal setospine either side near base of the sinus (but lacking in the holotype). Abdomen onesegmented covered dorsally by plate longer than wide and not extending to level of tips of caudal rami; margins at the greatest width of dorsal plate curved ventrally, giving the appearance, from dorsal aspect, of a slight projection: ventrally, joined broadly to genital double somite and posteriorly terminating in broad plate extending between bases of caudal rami. Caudal rami stout, curved, L-shaped in cross section; lateral surface is oblique proximally and follows line of abdomen to just beyond the widest point of dorsal abdominal plate beyond which level the caudal ramus is deēcted outwards and tapers to a terminal spine which recurves slightly back towards midline of the animal. Upper margin of caudal ramus is sharply de®ned beyond the stout spine, which marks the beginning of the curve outwards and carries a second smaller spine; ventral surface with tubercle near the proximo-lateral corner and with thin seta and small spine on the mesial edge. Oral area. Adhesion pads present at bases of antennule, antennae and maxillipeds. The surface structure of a pad is illustrated in ®gure 2B and C. Pads also present anteriorly on lateral expansions of thoracomere 2. Antennule (®gure 1C) of two articles: article 1 bearing 27 setospines, 21 stout and six small; article 2 bearing 12 naked, mostly curved, setae. Antenna of three articles (®gure 1D): terminal article bearing large curved terminal spine and two spines marginally; article 2 with two ventral spines, one mid-article on broad base, the other at the distal margin. Mouth tube (®gure 1E): of 10 females measured, oral cones 0.5±1.0 mm long, average 0.7 mm. Labrum ends in complex structure (®gure 2D). Labium with two terminal fringes of backwardly directed denticles (®gure 2D). Mandible (®gure 2D), with slender shaft ¯attened and dentate near the tip. Maxillule (®gure 1F) of two articles: basal article bearing 0 to two short setae; terminal article with large terminal, plus one small spine. Maxilla brachiform (®gure 1G): article 1 (lacertus) unarmed; article 2 (brachium) without ¯abellum, but with two distal spines, longer one fringed, shorter plumose; calamus bearing large claw with rows of spinules and apical patch of spinules. Maxilliped (®gure 1H) of two articles: basal article (corpus maxillipedus) stout with nacreous-like pad; article 2 (subchela) unequally bilobed, with nacreouslike pad, which works against pad of article 1. Legs 1±4 biramose, each ramus of two articles, with spine and setal formula as follows: Arabic numerals: setae. n P: plumose setae. Plumose setae are visible only at high magni®cations. Both rami of legs 1±3 (®gure 3A±C) with two articles. Both rami of leg 4 (®gure 3D) with one article; endopodite lacking spines. Leg 5 (®gure 3E) consisting of outer seta and inner lobe with single terminal spine. Adhesion pads and denticulate areas illustrated in ®gure 3A±D. Figure 2E shows detail of a denticulate region. Egg strings (®gure 3F) slender, approximately same length as body, slightly curved. Eggs disc shaped. Adult females vary in the extent of coloration. Colour patches dark chocolate± chestnut brown centrally shading outwards to transparent amber. Three colour patches occur on the cephalon, one anterior and triangular patches posterio-laterally. The considerable variation in the extent of separation to fusion between these three patches, resulting in considerable variation in the extent of amber-coloured areas about the eye spots, may be due to ontogenetic dierences. Colour patches also occur on frontal lobes; separately on segments 2 and 3 and at the bases of genital lobe projections; across most of segment 4 and abdominal segment (®gure 1A). Male (®gures 4, 5) Body form as in ®gure 4A and B. Length (not including setae on caudal rami) 5.2 ±7.2 mm (mean = 6.0 mm, n =5), width 2.9±4.3 mm (mean = 3.3 mm, n = 5) and height 0.84±0.94 mm (mean = 0.90, n = 5). Cephalon rounded when viewed dorsally with head and ®rst pediger fused. Segment 2 bears two pairs of dorsal spines; segments 3, 4 and 5 each bear one pair of dorsal spines. Pedigers 2± 4 free, without dorsal plates except for lateral wing-like plates on pediger 2. Genital double somite with posterior corners terminating in prominent triangular projection. Coiled spermatophores visible within genital double somite. Abdomen two-segmented. Caudal ramus bearing four long, plumose setae and series of ®ne setules along inner margin. Oral area as in female except for distribution of adhesion pads. Adhesion pad (®gure 4B) present at base of antennule (®gure 4C) approximatel y half the length, and positioned at greater angle towards centre of the cephalon, than is the case in the female. Small adhesion pad situated on base of antenna (®gure 4D). Absence of adhesion pads at base of maxilliped (®gure 4E) and on lateral projections of pediger 2. Legs 1±4 biramose, each ramus of two articles, with spine and setal formula as follows: Arabic numerals: setae. n P: plumose setae. Three sizes of setae are recognizable on the legs as follows: gigantic setae on article 1 of endopods 2±4; one very large, bipennate setae on article 1 of exopods 2 and 3 and three to eight setae on article 2 of all exopod and endopods; and smaller setae on both articles of exopods 1±4. Legs 1±4, ®gures 5A-D, which show the distribution of adhesion pads and denticulate areas. Leg 5 borne on genital double somite as lateral projection with three setae and one stout terminal spine. Leg 6 consisting of two setospines, outer longer than inner, borne on genital double somite near the origin of the abdomen. Colour in life is pale pink and devoid of darker pigment. Etymology Rhincodonicus refers to the host of the copepods, the whale shark, Rhincodon typus.Published as part of Norman, B. M., Newbound, D. R. & Knott, B., 2000, A new species of Pandaridae (Copepoda), from the whale shark Rhincodon typus (Smith), pp. 355-366 in Journal of Natural History 34 (3) on pages 357-364, DOI: 10.1080/002229300299534, http://zenodo.org/record/475739
Myocardial perfusion in heart disease
Get PDFHeart disease: Coronary heart disease is a major cause of mortality and morbidity in the UK and globally. It is managed with medical therapy and coronary revascularisation to reduce symptoms and reduce risk of major adverse cardiovascular events. When patients present with chest pain, it is important to risk stratify those that would most benefit from invasive coronary assessment and those that can be managed with medical therapy alone. Myocardial perfusion techniques have been developed in order to do this.
Cardiovascular magnetic resonance (CMR) with stress perfusion: CMR allows the non-invasive assessment of coronary artery disease (CAD). Under conditions of vasodilator stress, a gadolinium based contrast agent is injected and during the first pass through the left ventricle, perfusion defects can be observed. There is a strong evidence base for perfusion CMR but the technique is qualitative, relies on experienced operators and potentially misses globally low perfusion such as in cases of “balanced” ischaemia.
Quantitative perfusion CMR: In contrast, quantitative perfusion techniques allow the calculation of myocardial blood flow (MBF). It is more objective, less reliant on the expert observer and can give additional insights into microvascular disease and cardiomyopathy. As well as being less subjective, quantitative perfusion has other advantages for example it allows full assessment of ischaemic burden and may contain prognostic information that could be used to risk stratify and improve patient care. However, quantitative perfusion has been outside the realm of routine clinical practice due to difficulties in acquiring suitable data for full quantification and the laborious nature of analysing it.
Perfusion mapping: Peter Kellman, Hui Xue and colleagues at the National Institutes for Health, USA developed the “perfusion mapping” technique to address these limitations. Perfusion maps are generated automatically and inline during the CMR scan and each voxel encodes myocardial blood flow. This allows the instant quantification of MBF without complex acquisition techniques and post processing. In this thesis I have taken perfusion mapping and deployed in the real-world at a scale an order of magnitude higher than prior quantitative perfusion studies, developing the evidence base for routine clinical use across a broad range of diseases and scenarios:
In coronary artery disease: I have shown that perfusion mapping is accurate to detect coronary artery stenosis as defined by 3D quantitative coronary angiography in a single centre, 50 patient study. Transmural and subendocardial perfusion are particularly sensitive to detect coronary stenoses with performances similar to expert readers. There is a high sensitivity and high negative predictive value making perfusion mapping a good “rule-out” test for coronary disease.
Quantitative perfusion and prognosis: I investigated whether stress MBF and myocardial perfusion reserve (MPR) calculated by perfusion mapping would encode prognostic information in a 1049 patient multi-centre study over a mean follow up time of 605 days. Both stress MBF and MPR were independently associated with death and major adverse cardiovascular events (MACE). The hazard ratio for MACE was 2.14 for each 1ml/g/min decrease in stress MBF and 1.74 for each unit decrease in MPR. This work can now be taken forward with prospective studies in order to better risk stratify patients, including those without perfusion defects on clinical read.
Reference ranges and non-obstructive coronary disease: I sought to determine the factors that contribute to perfusion in a multi-centre registry study. In patients with no obstructive coronary artery disease, stress MBF was reduced with age, diabetes, left ventricular hypertrophy (LVH) and the use of beta blockers. Rest MBF was influenced by sex (higher in females) and reduced with beta blockers. This study suggests patient factors beyond coronary artery disease (and therefore likely microvascular disease) should also be considered when interpreting quantitative perfusion studies.
In cardiomyopathy: I also investigated myocardial perfusion in cardiomyopathy looking at Fabry disease as an example disease. In a prospective, observational, single centre study of 44 patients and 27 controls I found Fabry patients had reduced perfusion (and therefore likely microvascular dysfunction), particularly in the subendocardium and was associated with left ventricular hypertrophy (LVH), glycophospholipid storage and scar. Perfusion was reduced even in patients without LVH suggesting it is an early disease marker.
In conclusion, in this thesis, I have developed an evidence base for quantitative perfusion CMR and demonstrated how it can be integrated into routine clinical care. Perfusion mapping is accurate for detecting coronary artery stenosis and encodes prognostic information. Further work in this area could enable patients to be risk stratified based on their myocardial perfusion in order to reduce the morbidity and mortality associated with epicardial and microvascular coronary artery disease. Following on from this work, two further British Heart Foundation Clinical Research Training Fellowships have been awarded to further investigate quantitative perfusion in patients following surgical revascularisation of coronary disease and in patients with hypertrophic cardiomyopathy
Blueberry Ridge School District No. 4562 - 03
No full textPhotograph - Pupils at a school concert at Blueberry Ridge School near Rochester, Alberta. Left to right: Teacher, Miss Taylor, and students, Ethel Hurley, Ruby Hicks, Arnold Knott, Ann Lukeski, Ruth Ward, Mary Wilson, Alex Panalack, Ernst Hahn, Eva Hurley and Kenneth WardTaylor, Miss; Hurley, Ethel; Hicks, Ruby; Knott, Arnold; Lukeski, Ann; Ward, Ruth; Wilson, Mary; Panalack, Alex; Hahn, Ernst; Hurley, Eva; Ward, Kennet
Uncorrelated interference in 79 GHz FMCW and PMCW automotive radar
No full textAn extensive comparison on radar-to-radar interference in frequency-modulated continuous wave (FMCW) and binary phase-modulated continuous wave (PMCW) radars is performed. The noise-plus-interference power for FMCW-to-FMCW and PMCW-to-PMCW interference in a single victim and single interferer environment is compared for generalized waveform-based scenarios. It is proven that the interference suppression is equal in FMCW and PMCW radars in case the time-bandwidth product in both systems is equal
Linkage and Association Mapping for Quantitative Phenotypes in Isolated Populations
Get PDFThis thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: • This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. • A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. • This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. • The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. • When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given.
Tell Don't Show: The invisible plague in seventeenth-century Dutch interior paintings
No full textThroughout most of the seventeenth century plague epidemics raged through Dutch cities and took their toll in an enormous loss of life. However, seventeenth-century paintings of domestic life do not show the sorrow or the death toll, but portray healthy, thriving mothers and children in sunlit interiors. The sunny imagery of the seventeenth-century painting is so strong that it defies the historic reality of the countless plague victims. In a strange contradiction, up until the Dutch language harbours numerous references to The Plague, or pest as it is called in Dutch. My perception of the glorious Dutch Golden Age, and the sunny imagery if seventeenth-century interior paintings in particular, changed after reading the published transcripts of seventeenth-century Dutch letters written by women to their husbands at sea. What struck me most were the women's heartbreaking accounts of the loss of children due to The Plague. I have since tried to detect evidence of this daily reality in the paintings, given that art historians have warned against their deceptive realism.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Situated Architectur
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