110,296 research outputs found
India: <i>General</i>: S. L. N. Simha and Janari G. Krishnan: The Saga of Silver. Institute for Financial Management and Research, Madras, 1980, xiv, 208p., Rs. 40.
No full text INDIA: General: S.L.N. SIMHA and JANAKI G. KRISHNAN: The Saga of Silver. </jats:p
Effect of Mach number on the structure of turbulent spots
No full textDirect numerical simulations have been performed to study the dynamics of isolated turbulent spots in compressible isothermal-wall boundary layers. Results of a bypass transition scenario at Mach 2, 4 and 6 are presented. At all Mach numbers the evolved spots have a leading-edge overhang, followed by a turbulent core and a calmed region at the rear interface. The spots have an upstream-pointing arrowhead shape when visualized by near-wall slices, but a downstream-pointing arrowhead in slices away front the wall. The lateral spreading of the spot decreases substantially with the Mach number, consistent with a growth mechanism based on the instability of lateral shear layers. Evidence for a supersonic (Mach) mode substructure is found in the Mach 6 case, where coherent spanwise structures are observed under the spot overhang region
Dendritic cell TH2 cytokine gene therapy in sheep
No full textT. Coates, R. Krishnan, G. Chew, S. Kireta, J. Johnston, B. Kanachanabat, C.H. Russell, M. Siddins, and G.R. Rus
Is there Less Earnings Management when there Are More Accounting Experts on the Audit Committee?
No full textThe lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: a review of the literature on ethinyl estradiol 20 &micro;g/levonorgestrel 100 &micro;g + ethinyl estradiol 10 &micro;g
No full textSheila Krishnan, Jessica KileyDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USAAbstract: Extended-cycle oral contraceptives (OCs) are increasing in popularity in the United States. A new extended-cycle OC that contains the lowest doses of ethinyl estradiol (EE) and levonorgestrel (LNG) + continuous EE throughout the cycle is now available. It provides 84 days of a low-dose, combined active pill containing levonorgestrel 100 &micro;g and ethinyl estradiol 20 &micro;g. Instead of 7 days of placebo following the active pills, the regimen delivers 7 days of ethinyl estradiol 10 &micro;g. Existing studies reveal a similar efficacy and adverse effect profile compared with other extended-regimen OCs. Specifically, the unscheduled bleeding profile is similar to other extended-cycle OCs and improves with the increase in the duration of use. Although lower daily doses of hormonal exposure have potential benefit, to our knowledge, there are no published studies indicating that this specific regimen offers a lower incidence of hormone-related side effects or adverse events. In summary, this new extended-cycle OC provides patients a low-dose, extended-regimen OC option without sacrificing efficacy or tolerability.Keywords: continuous regimen, ethinyl estradiol, extended cycle, oral contraceptiv
Consumption of animal products, their nutrient components and postmenopausal circulating steroid hormone concentrations
No full textBackground/Objectives: Little is known about nutritional factors that influence circulating concentrations of steroid hormones, which are consistently associated with risk of breast cancer for postmenopausal women. We aimed to investigate the association between consumption of animal products and the plasma concentrations of steroid hormones and sex hormone-binding globulin (SHBG). Subjects/Methods: Cross-sectional analysis was conducted on plasma from 766 naturally postmenopausal women. We measured plasma concentrations of steroid hormones and SHBG, and estimated dietary intakes using a 121-item food frequency questionnaire. Log-transformed values of hormone concentrations were regressed on quartiles of intake of meat and dairy products among food items, and fats, proteins and cholesterol among nutrient intake. Results: Total red and fresh red meat consumption was negatively associated with SHBG levels (P for trend=0.04 and <0.01, respectively). Mean SHBG concentrations were ~8% and 13% lower for women in the highest quartile compared with the lowest quartile of total red and fresh red meat consumption, respectively. Positive associations were observed between dairy product consumption and total and free estradiol concentrations (P for trend=0.02 and 0.03, respectively). Mean concentrations of total and free estradiol were 15 and 14% higher for women in the highest quartile of dairy product consumption than for those in the lowest quartile, respectively. No associations were observed with consumption of processed meat, chicken, fish, eggs, cholesterol, fats or protein. Conclusions: Our study suggests that greater consumption of total red and fresh red meat and dairy products might influence circulating concentrations of SHBG and estradiol, respectively. Confirmation and further investigation is required.MT Brinkman, L Baglietto, K Krishnan, DR English, G Severi, HA Morris, JL Hopper and GG Gile
Soft, wireless electronics for the thermal characterization of skin and soft tissue
No full textExisting sensors to monitor physical biomarkers in living tissue are rigid, bulky and often require wired electronic connections for power and data transfer. Recent work has established a set of design principles that allow for the integration of traditionally rigid sensing electronics and wiring into form factors that are soft, flexible and stretchable. These sensors offer qualitative improvements in patient comfort and are comparable, if not superior to clinical gold standard technologies. The strong, conformal mechanical coupling between these sensors and underlying living tissue also opens new avenues for unusual sensing modalities with immediate applications in clinical medicine. Devices for the continuous thermal characterization of living tissue represent one such opportunity and the work presented here illustrates a set of materials, mechanics and electronics designs required to realize fully functional sensors for temperature and flow mapping through biological conduits. Advanced powering and data transmission and powering schemes relying on near-field communication and Bluetooth protocols allow the sensors to be continuously worn for extended periods. Measurements of hydration in outer skin layers, cerebrospinal fluid flow through indwelling ventricular shunts and blood flow through peripheral nerve vasculature represent three use cases in dermatology, neurosurgery and neuroscience, respectively. Systematic benchtop and theoretical studies illustrate the high levels of functionality of these devices, and IRB approved studies on over 30 patients and volunteers, along with comparisons to clinical gold standards highlight their potential beyond the laboratory.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-08-01The student, Siddharth Krishnan, accepted the attached license on 2019-06-01 at 19:10.The student, Siddharth Krishnan, submitted this Dissertation for approval on 2019-06-01 at 19:14.This Dissertation was approved for publication on 2019-06-11 at 10:22.DSpace SAF Submission Ingestion Package generated from Vireo submission #14013 on 2019-11-26 at 13:59:35Made available in DSpace on 2019-11-26T20:56:45Z (GMT). No. of bitstreams: 2
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Previous issue date: 2019-06-11Embargo set by: Seth Robbins for item 113003
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113003
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113003
Lift date: 2021-11-26T20:58:44Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 113003
Lift date: 2021-11-26T20:59:54Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 113003 on 2021-11-27T10:15:20Z
Data for: Factors influencing the download of mobile health apps: Content review cum regression analysis
No full textThe data set shows the diabetes mobile app basic details, classification and analysis
Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition
No full textSteroid hormones are associated with the risk of postmenopausal breast cancer and evidence suggests that increased concentrations of oestrogens from peripheral aromatisation in adipose tissue partly explains the association between body mass index (BMI) and risk of postmenopausal breast cancer. This study examined the associations between circulating concentrations of steroid hormones and anthropometric measurements in a sample of naturally postmenopausal women from the Melbourne Collaborative Cohort Study, not using hormone replacement therapy.
We measured plasma concentration of total oestradiol, oestrone sulphate, dehydroepiandrosterone sulphate, androstenedione, testosterone and sex hormone binding globulin (SHBG) and calculated concentration of free oestradiol. Body measurements included height, weight, BMI, waist circumference, fat mass and fat-free mass, the last two estimated by bioelectrical impedance analysis. BMI was positively associated with both oestrogens and androgens and negatively with SHBG. Fat mass was the principal measure responsible for the association observed between body size and total oestradiol. The associations between oestrone sulphate and androgens and body size were mainly with waist circumference.
The associations between oestrogens and body size were close to null for the first 6 years since menopause and became positive thereafter. Our results are compatible with the hypothesis that after the menopause excess fat mass increases oestrogen concentrations through the peripheral aromatisation of androgens in adipose tissue. This effect requires around 6 years to be detectable by way of circulating steroid hormone levels.Laura Baglietto, Dallas R. English, John L. Hopper, Robert J. MacInnis, Howard A. Morris, Wayne D. Tilley, Kavitha Krishnan and Graham G. Gile
バイノールヲボカクニユウスルヒカリオウトウセイフセイショクバイ：ソノデザイントマンニッヒガタハンノウオヨビアザ-フリーデル-クラフトハンノウヘノオウヨウテンカイ
No full textKrishnan C.G., Kondo M., Nakamura K., et al. Photoswitchable Chiral Cation-Binding Catalyst: Photocontrol of Catalytic Activity on Enantioselective Aminal Synthesis. Organic Letters 24, 2670, American Chemical Society, (2022); https://doi.org/10.1021/acs.orglett.2c00741.Krishnan C.G., Kondo M., Yasuda O., et al. Light-controlled pKa value of chiral Brønsted acid catalysts in enantioselective aza-Friedel-Crafts reaction. Chemical Communications 59, 9956, Royal Society of Chemistry, (2023); https://doi.org/10.1039/D3CC02719H
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