5 research outputs found
Granulomatous disease in selective IgA deficiency
No full textAlthough common variable immunodeficiency (CVID) is sometimes associated with sarcoidosis/granulomatous disease, there have only been isolated reports of selective immunoglobulin A (IgA) deficiency and granulomatous disease. We present a patient with IgA deficiency who developed Heerfordt syndrome, a variant of neurosarcoidosis. This specific entity has not been previously reported to occur in IgA deficiency. Our case expands the reported associations of IgA deficiency and provides another example to the paucity of reported cases of sarcoidosis occurring in patients with IgA deficiency. As CVID and IgA deficiency have common underlying genetic factors, such an association is biologically plausible.Vidya Limaye, Tim Lu, Eugene Ang, Amirtharajan Krishnan, Pravin Hissaria and David Gilli
Astigmatic neutrality in biaxial microincision cataract surgery
No full textPURPOSE: To assess the astigmatic effect of biaxial microincision cataract surgery (MICS) with insertion of an UltraChoice 1.0 Rollable Thinlens intraocular lens (IOL) in a sufficiently powered controlled study.
SETTING: Queen Elizabeth Hospital, South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, Australia.
METHODS: Consecutive patients having biaxial MICS were evaluated prospectively. Keratometry was performed preoperatively and postoperatively. Vector analysis of the alteration in the keratometric cylinder was compared with that in control eyes not having surgery but having keratometry over a similar time frame.
RESULTS: There were 76 eyes in the surgical group and 74 in the control group. The right-hand incision used for IOL insertion had a mean external opening width of 2.00 mm and a mean internal width of 1.89 mm. The left-hand incision measured a mean of 1.49 mm and 1.46 mm, respectively. There was no statistically significant difference between the surgical group and the routine variability in keratometry in the untreated control group in surgically induced astigmatism (surgical group, 0.57 diopter [D] +/- 0.05 [SEM]; control group, 0.54 +/- 0.06 D; P = .660) or the degree of mean calculated flattening effect at the right-hand incision (0.01 +/- 0.06 D and -0.05 +/- 0.05 D, respectively; P = .405) or at the left-hand incision (-0.06 +/- 0.05 D and 0.03 +/- 0.06 D, respectively; P = .283).
CONCLUSION: Biaxial MICS with insertion of IOL through a temporal incision of 2.0 mm offers prospects of astigmatic neutrality in cataract surgery.
