152 research outputs found
Inventory strategies for patented and generic products for a pharmaceutical supply chain
No full textThesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 76-77).This thesis presents a model to determine safety stock considering the distinct planning parameters for a pharmaceutical company. Traditional parameters such as forecast accuracy, service level requirements and average lead-time are combined with a nontraditional upstream uncertainty parameter defined as supply reliability. In this instance, supply reliability measures uncertainty in the supply quantity delivered rather than variability in the lead-time for delivery. We consider the impact of the safety stock using two products: a proprietary product that is patented and a generic product that recently went off patent. Sensitivity analysis is performed to provide insights on the impact of variations in input parameters. The study shows that there is a significant difference in safety stock between the proposed model and the current model used by the company.by Prashanth Krishnamurthy and Amit Prasad.M.Eng.in Logistic
Sliding mode control of discrete-time weakly coupled systems
No full textSliding mode control is a form of variable structure control which is a powerful tool to cope with external disturbances and uncertainty. There are many applications of sliding mode control of weakly coupled system to absorption columns, catalytic crackers, chemical plants, chemical reactors, helicopters, satellites, flexible beams, cold-rolling mills, power systems, electrical circuits, computer/communication networks, etc. In this thesis, the problem of sliding mode control for systems, which are composed of two weakly coupled subsystems, is addressed. This thesis presents several methods to apply sliding mode control to linear discretetime weakly-coupled systems and di fferent approaches to decouple the sub-systems. The application of Utkin and Young's sliding mode control method on discrete-time weakly-coupled systems is studied in detail which is then compared with other control algorithms while emphasizing the importance of the decoupling technique in each case. It also presents the possibility of integrating two or more control strategies for a single system; one for each sub-system, depending upon the respective requirements and constraints. In this thesis, the eff ectiveness of the proposed methods is demonstrated through theory and simulation results.M.S.Includes bibliographical referencesIncludes vitaby Prashanth Kumar Gopal
Author recognition using Locality Sensitive Hashing & Alergia (Stochastic Finite Automata)
No full textIn today’s world data grows very fast. It is difficult to answer questions like 1) Is the content completely written by this author, 2) Did he get few sentences or pages from another author, 3) Is there any way to identify actual author. There are many plagiarism software’s available in the market which identify duplicate content. It doesn’t understand writing pattern involved. There is always a necessity to make an effort to find the original author. Locality sensitive hashing is one such standard for applying hashing to recognize authors writing pattern
Preparation and characterization of biodegradable chitosan based nanocomposite films for food packaging application.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Preparation and characterization of biodegradable chitosan-poly-€-caprolactone based nanocomposite blendfilms.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Matrix Pencil Based On-Line Computation of Controller Parameters in Dynamic High-Gain Scaling Controllers for Strict-Feedback Systems
No full textWe propose a new matrix pencil based approach for design of state-feedback
and output-feedback stabilizing controllers for a general class of uncertain
nonlinear strict-feedback-like systems. While the dynamic controller structure
is based on the dual dynamic high-gain scaling based approach, we cast the
design procedure within a general matrix pencil structure unlike prior results
that utilized conservative algebraic bounds of terms arising in Lyapunov
inequalities. The design freedoms in the dynamic controller are extracted in
terms of generalized eigenvalues associated with matrix pencils formulated to
capture the detailed structures (locations of uncertain terms in the system
dynamics and their state dependences) of bounds in the Lyapunov analysis. The
proposed approach enables efficient computation of non-conservative bounds with
reduced algebraic complexity and enhances feasibility of application of the
dual dynamic high-gain scaling based control designs. The proposed approach is
developed under both the state-feedback and output-feedback cases and the
efficacy of the approach is demonstrated through simulation studies on a
numerical example.Comment: 20 pages; 2 figure
Studies on Self assembly of Low Molecular Weight Chitosan.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Updated area function analysis for nano indentation of micro fibers
No full textKevlar has a remarkable combination of high strength, high modulus, toughness and thermal stability compared to many other organic fibers. These impressive properties are due to their molecular structure, developed during their production process which is based on liquid crystal technology, as the rigid molecular chains form a mesophase in solution. Modeling of the high-performance ballistic fabric has gradually shifted from the continuum and yarn length scales to the sub-yarn length scale which enabled establishment of the relationships between the fabric penetration resistance and various fiber-level phenomena such as fiber-fiber friction, fiber twist, and transverse properties of the fibers. An instrumented indentation method was established in this thesis work to accurately measure the local elastic-plastic material properties of a single fiber. As indentation theory assumes that the indent is being placed on a semi-infinite flat surface, general area function cannot predict accurate projected area on a circular specimen. The indentations on cylindrical surface require modified equations to determine the area function and subsequently, the hardness and reduced modulus. The Oliver-Pharr instrumented indentation data analysis method is followed for the calculation of area function of the indenter geometry through the simulation of the known properties of the material. This new area function calculation method is compared with the geometry correction method by Quinn McAllister and John W. Gillespie, Jr to calculate the elastic modulus of the fiber in transverse direction. In addition, Compliance contributions are attributed to the lack of constraint due to the finite geometry of a curved fiber surface. This compliance contribution is accounted by using a proposed area correction to capture the geometry of the curved fiber-probe contact. Implementation of these corrections to experimental indentation curves results in accurate measurements of the fiber elastic modulus.M.S.Includes bibliographical referencesby Prashanth Turl
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