194,233 research outputs found
Shifting waterscapes: explaining basin closure in the Lower Krishna Basin, South India
No full textRiver basins / Ecosystems / Protective irrigation / Irrigation programs / Water transfer / Water distribution / Water allocation / Groundwater depletion / Aquifers / Water scarcity / Water use / Drought / India / Lower Krishna Basin / Godavari Basin / Nagarjuna Sagar Project / Kolleru Lake
The lower Krishna Basin trajectory: relationships between basin development and downstream environmental degradation
No full textRiver basin development / Lakes / Environmental degradation / Ecosystems / Mangroves / Water allocation / Groundwater / Water quality / Salinity / Irrigated farming / Institutions / Irrigation canals / Rural development
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.
No full textBACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
METHODS: Plasmodium falciparum isolates cultured from 28 returning travellers diagnosed with malaria were assessed for sensitivity to artemisinin, artemether, dihydroartemisinin and artesunate and findings related to mutations in pfatp6 and pfmdr1.
RESULTS: Resistance to artemether in vitro was significantly associated with a pfatp6 haplotype encoding two amino acid substitutions (pfatp6 A623E and S769N; (mean IC50 (95% CI) values of 8.2 (5.7 - 10.7) for A623/S769 versus 623E/769 N 13.5 (9.8 - 17.3) nM with a mean increase of 65%; p = 0.012). Increased copy number of pfmdr1 was not itself associated with increased IC50 values for artemether, but when interactions between the pfatp6 haplotype and increased copy number of pfmdr1 were examined together, a highly significant association was noted with IC50 values for artemether (mean IC50 (95% CI) values of 8.7 (5.9 - 11.6) versus 16.3 (10.7 - 21.8) nM with a mean increase of 87%; p = 0.0068). Previously described SNPs in pfmdr1 are also associated with differences in sensitivity to some artemisinins.
CONCLUSIONS: These findings were further explored in molecular modelling experiments that suggest mutations in pfatp6 are unlikely to affect differential binding of artemisinins at their proposed site, whereas there may be differences in such binding associated with mutations in pfmdr1. Implications for a hypothesis that artemisinin resistance may be exacerbated by interactions between PfATP6 and PfMDR1 and for epidemiological studies to monitor emerging resistance are discussed
Polymorphism and polytypism in crystals, par A. R. Verma et P. Krishna, 1966
No full textHerpin Paulette. Polymorphism and polytypism in crystals, par A. R. Verma et P. Krishna, 1966. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 89, 3, 1966. p. 416
Polymorphism and polytypism in crystals, par A. R. Verma et P. Krishna, 1966
No full textHerpin Paulette. Polymorphism and polytypism in crystals, par A. R. Verma et P. Krishna, 1966. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 89, 3, 1966. p. 416
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Contested genealogies and cross-cultural dynamics in the Hare Krishna movement
No full textWhen and where to begin the story of Hare Krishna? I could begin by tracing the genealogy of the International Society for Krishna Consciousness (ISKCON, or the Hare Krishna movement) back to the long established tradition of Krishna devotionalism to which its founding leader, the Bengali Vaisnava renunciate A. C. Bhaktivedanta Swami Prabhupada (1896–1977), belonged in India. ISKCON devotees themselves trace their sacred genealogy, through Prabhupada and the Bengali Vaisnava tradition, all the way back to Lord Krishna (God) Himself. As an outside observer, I can tentatively concede there is a historical Indian tradition which Prabhupada represented
Granulometric Studies on Modern Barrier System of the Right Bank of Krishna Delta, East Coast of India
No full text283-286Granulometric studies have been undertaken on 3 sand spits present on the right bank of the Krishna River confluence with the Bay of Bengal. The size parameters (mean size, standard deviation, skewness and kurtosis) and CM diagrams are discussed. The past and the present growth rates of the delta are evaluated to support the granulometric studies. Major spits 1 and 2 have reached stability while spit 3, which emerged at the mouth is still in active growth. The progradation of the Krishna Delta is due to the development of the bars and spits, leading to the consequent filling of the lagoonal areas. The present progradation of the deltaic facies ultimately may pave the way for the disappearance of the bay
Molecular and genetic analysis of anthranilate synthase in Arabidopsis thaliana
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1993.Includes bibliographical references.by Krishna K. Niyogi.Ph.D
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
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