393 research outputs found
Letter from Wyman Spooner to Alden Partridge, 19 May 1823.
No full textDefends his publication of the "parody" in his newspaper, which Partridge found so offensive to himself and his Academy; will not release the name of the author unless Partridge intends to prosecute him for libel and take the case before a civil tribunal.See letter of 13 May 1823. Transcription by Alison Horner. Transcriptions may be subject to error
Letter from Mr. Tilden to Alden Partridge, approximately 1821-1823
No full textUndated invitation to dinner from Mr. Tilden (Joseph Tilden?) to Alden Partridge; addressed to Partridge at Earls Coffee House, Hanover Street; the author writes from Franklin Place; possibly written between 1821 and 1823.Transcription by Raymond Bouchard. Transcriptions may be subject to error
Letter from John Pintard to Alden Partridge, 5 May 1826.
No full textEbenzer Irving leaves the city to attend the examination; Don Pizarro will be joining the Academy as instructor of the Spanish language; urges Partridge to employ first-rate instructors; understands Partridge is marching his cadets to New Haven and hopes his grandsons and Mr. Wedenstrandt will accompany them.Mentions a pedestrian excursion to New Haven, CT. Ebenezer Irving was the brother of the famous author, Washington Irving, 1783-1859
Gene delivery in bone tissue engineering: progress and prospects using viral and nonviral strategies
No full textBone tissue loss as a consequence of the natural aging process or as a result of trauma and degenerative disease has led to the need for procedures to generate cartilage and bone for a variety of orthopedic applications. The ability to transfer genes into multipotential mesenchymal stem cells, while still in its infancy, offers considerable therapeutic hope in a variety of musculoskeletal disorders. However, the choice of gene delivery method is key. This review examines the various techniques and methods currently available to enable gene transfer into a target population from viral methods (transduction) to nonviral (transfection) methods and the limitations associated with each method. The potential applications and current understanding of each method are presented. Given the demographic challenge of an aging population, the ultimate goal remains the development of simple, safe, and reproducible strategies for gene delivery that will address the pressing orthopedic clinical imperatives of many
Letter from Daniel Hatch to Alden Partridge, 20 February 1828.
No full textRegarding the organization of the military department of his academy; discusses the salary and qualifications he would like in a teacher; Partridge should send someone who conforms to these requirements.Part of cover torn away. The author writes from the unincorporated community of Darvills, Virginia in Dinwiddie County
Letter from Thomas Bennett to Alden Partridge, 17 June 1826
No full textThomas Bennett writes from Charleston, South Carolina, to Alden Partridge at the American Literary, Scientific, and Military Academy in Middletown, Connecticut, regarding the speech impediment of his son Washington Jefferson Bennett; he wishes Washington to be allowed a furlough to travel to New York City to see Mrs. Leigh (Jane Leigh, author of "Facts in relation to Mrs. Leigh’s system of curing stammering, and other impediments of speech," 1826).Transcription by Sarah Cruz. Transcriptions may be subject to error
Letter from Tobias Watkins to Alden Partridge, 19 September 1815.
No full textNotes that he had expressed in print his gratification for a recent visit to West Point in the "Weekly Register" and asks Partridge to keep that information (identity of the author) to himself; had receieved a letter from friend Thayer who was on his way to Paris; had also seen their mutual friend Judge Nicholson.Transcription by Anna Helena Denis. Transcriptions may be subject to error
Regarding the use of the Meeting House in Norwich, VT, 12 January 1835
No full textSubscription list regarding the use of the Meeting House in Norwich, Vermont, dated 12 January 1835. Subscribers include Alden Partridge, John Wright, and Joseph Emerson.Transcription by Raymond Bouchard. Transcriptions may be subject to error
Response to the author of the "Parody" published in the Vermont Journal, 30 April 1823
No full textResponse to the author (thought to be Thomas Freelon) of the "Parody" which had been published in the last edition of the Vermont Journal. The parody was critical of Alden Partridge and his school (the American Literary, Scientific, and Military Academy).Transcription by Joseph Byrne. Transcriptions may be subject to error
Biological and mechanical enhancement of impacted allograft seeded with human bone marrow stromal cells: potential clinical role in impaction bone grafting
No full textWith the demographics of an aging population the incidence of revision surgery is rapidly increasing. Clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. Impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone, the success of which relies on a combination of mechanical and biological factors. The use of morsellized allograft is currently the accepted clinical standard providing a good mechanical scaffold with little osteoinductive biological potential. We propose that applying the principles of a tissue engineering paradigm, the combination of human bone marrow stromal cells (hBMSCs) with allograft to produce a living composite, offers a biological and mechanical advantage over the current gold standard of allograft alone. This study demonstrates that hBMSCs combined with allograft can withstand the forces equivalent to a standard femoral impaction and continue to differentiate and proliferate along the bony lineage. In addition, the living composite provides a biomechanical advantage, with increased interparticulate cohesion and shear strength when compared with allograft alone
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